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San Francisco 49ers vs Arizona Cardinals 11/7/21 NFL Picks and Predictions

Arizona Cardinals (7-1) vs. San Francisco 49ers (3-4)
November 7, 2021 4:25 pm EDT
The Line: San Francisco 49ers +2.5 / Arizona Cardinals -2.5; Over/Under: +47
(Get latest betting odds)

The San Francisco 49ers and Arizona Cardinals clash in a week 9 NFC West NFL contest from Levi’s Stadium on Sunday afternoon.

The Arizona Cardinals will look to rebound from a heartbreaking 24-21 loss to Green Bay for their first defeat of the season. Kyler Murray has thrown for 2,276 yards, 17 touchdowns and 7 interceptions on 72.7% passing while Chase Edmonds has rushed for 427 yards and James Conner has 358 rushing yards with 8 TDs this season. DeAndre Hopkins has a team-high 35 catches for 486 yards and 7 TDs while A.J. Green and Christian Kirk each have 450+ receiving yards. Rondale Moore has 327 receiving yards while three other Cardinals have at least 100 receiving yards as well this season. On defense, Jordan Hicks leads the Cardinals with 56 total tackles while also logging 3 sacks while Byron Murphy Jr. has 3 interceptions and Markus Golden has a team-high 6 sacks. Chandler Jones also has 5 sacks for Arizona this season.

The San Francisco 49ers will be out to build on a 33-22 win over Chicago in their last game. Jimmy Garoppolo has thrown for 1,428 yards, 6 touchdowns and 4 interceptions on 64.2% passing while Elijah Mitchell has a team-high 433 rushing yards and 3 touchdowns this season. Deebo Samuel leads San Francisco’s receiving group with 44 grabs for 819 yards and 4 TDs while George Kittle’s posted 227 receiving yards and another three 49ers have at least 100 receiving yards as well this season. On defense, Fred Warner leads the Niners with 61 total tackles while Nick Bosa has a team-high 7 sacks.

Arizona is 11-5 ATS in their last 16 games against a team with a losing record and 5-1 ATS in their last 6 games overall while the under is 4-0 in their last 4 games as a favorite. San Francisco is 1-6 ATS in their last 7 home games and 1-4 ATS in their last 5 games overall while the over is 5-1 in their last 6 games following a win.

I’m leaning towards the under here. I know the Cardinals have a solid offense, but I think San Fran’s best chance to stay in this game is to focus on defense and I don’t think San Francisco’s offense is going to go off here either. This is going to be a defensive war and I think the under comes in when all is said and done.

Chris Ruffolo's Free Pick: Under 47

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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