49ers vs Panthers Prediction 11/24/25 NFL Picks Today

The Carolina Panthers and the San Francisco 49ers meet in week 12 NFL action from Levi’s Stadium on Monday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a 49ers vs Panthers Prediction.

Carolina Panthers Recap

The Carolina Panthers come into this game looking to add on to a 30-27 win over Atlanta last time out to sit at 6-5 this season. After this game, Carolina will head home for a game against the Los Angeles Rams.

Panthers Alternate Wins & Losses In 5 Straight

Bryce Young has thrown for 1,962 yards, 14 touchdowns and 7 interceptions on 62.7% passing while Andy Dalton has 293 passing yards, a touchdown and an interception on 67.6% passing. Rico Dowdle has a team-high 833 rushing yards and 5 TDs and Chuba Hubbard has 334 rushing yards as well this season. Tetairoa McMillan has a team-high 54 catches for 746 yards and Xavier Legette has 264 receiving yards and 3 TDs while seven more Panthers have 100+ receiving yards as well on the year. On defense, Christian Rozeboom has a team-high 91 total tackles. As a unit, Carolina’s defense has combined for 16 sacks and 7 interceptions so far this season.

Why the Carolina Panthers will win

• The Panthers have won each of their last four games as underdogs against NFC opponents.
• The 49ers have lost five of their last six games as home favorites following a win.
• The 49ers have failed to cover the spread in each of their last 12 home games following a win.
• The Panthers have covered the spread in each of their last six games as underdogs against NFC opponents.

Carolina Panthers Player Prop Facts

• Chuba Hubbard has scored a touchdown in four of his last five appearances against teams that held a winning record.
• Bryce Young has recorded 203+ passing yards in four of the Panthers’ last five road games against NFC opponents.
• Chuba Hubbard has recorded 34+ rushing and receiving yards in each of his last 12 appearances with the Panthers as underdogs following a win.
• Xavier Legette has recorded 22+ receiving yards in each of the Panthers’ last five November games as underdogs.
• Chuba Hubbard has recorded 17+ rushing yards in each of his last 21 appearances with the Panthers as underdogs.
• Bryce Young has recorded 18+ completions in each of the Panthers’ last four road games as moderate underdogs (+3.5 to +7.0 points).
• Heading into Week 12, Jaycee Horn has recorded the equal-most interceptions in a single game this season (2 vs Jets, Week 7).

San Francisco 49ers Recap

The San Francisco 49ers come into this game looking to add on to their 41-22 win over Arizona last time out to sit at 7-4 this season. After this game, San Francisco will head on the road for a game against the Cleveland Browns.

49ers Alternate Wins & Losses In 9 In A Row

Mac Jones has thrown for 2,151 yards, 13 touchdowns and 6 interceptions on 69.6% passing while Brock Purdy has thrown for 786 yards, 7 touchdowns and 4 interceptions on 67.7% passing. Christian McCaffrey has a team-high 707 rushing yards while also leading the 49ers in receiving with 74 grabs for 732 yards and 5 touchdowns. Ricky Pearsall has 327 receiving yards and 20 receptions while Kendrick Bourne has 482 receiving yards and Jauan Jennings has 378 receiving yards and 3 TDs. Two more 49ers have 200+ receiving yards and another pair have 150+ receiving yards as well on the year. On defense, Dee Winters has a team-high 77 total tackles. As a unit, San Francisco’s defense has combined for 12 sacks and 3 interceptions so far this season. 

Why the San Francisco 49ers will win

• The Panthers have lost each of their last 11 games following a road win.
• The 49ers have won each of their last five home games against NFC South opponents.
• The Panthers have failed to cover the spread in each of their last 11 games following a road win.
• The favorites have covered the spread in seven of the 49ers’ last eight Week 12 games.

San Francisco 49ers Player Prop Facts

• Christian McCaffrey has scored two or more touchdowns in three of the 49ers’ last four games against NFC opponents.
• George Kittle has recorded 61+ receiving yards in each of his last seven regular season appearances with the 49ers as home favorites against NFC opponents.
• Christian McCaffrey has scored at least one touchdown in 10 of his 11 appearances with the 49ers as home favorites against teams that held a winning record.
• Mac Jones has recorded 279+ passing yards in each of the 49ers’ last four games following a road win.
• Christian McCaffrey has recorded 121+ rushing and receiving yards in each of the 49ers’ last four games as favorites.
• Brock Purdy has recorded 11+ rushing yards in 12 of his last 13 appearances in California.
• Mac Jones has recorded 26+ completions in each of the 49ers’ last four games following a road win.
• Heading into Week 12, Christian McCaffrey is the only player in the NFL to record 5+ rushing and 5+ receiving TDs this season.

Total Points Facts

• Each of the 49ers’ last five November games against NFC South opponents have gone UNDER the total points line.
• Each of the Panthers’ last four games against NFC West opponents have gone OVER the total points line.
• Each of the last three Monday games at Levi’s Stadium have gone OVER the total points line.

49ers vs Panthers Prediction

I’m on the over here. I think that San Francisco is going to be able to put up points here, but there’s also an avenue for success for Carolina, as San Francisco’s defense is just ravaged by injuries. We just saw Bryce Young set a franchise record for passing for Carolina, and this Panthers team is getting more and more confident in themselves with each passing week as the potential for playoff football draws near. Give me the over here.