49ers vs Bears Prediction 12/28/25 NFL Picks Today

The Chicago Bears and the San Francisco 49ers meet in week 17 NFL action from Levi’s Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a 49ers vs Bears Prediction.

Chicago Bears Recap

The Chicago Bears come into this game looking to add on to their 22-16 win over the Green Bay Packers last time out to sit at 11-4 this season. After this game, Chicago will head home for a game against the Detroit Lions.

Bears Clinch Playoff Spot

Caleb Williams has thrown for 3,400 yards, 23 touchdowns and 6 interceptions on 57.8% passing while D’Andre Swift has rushed for 993 yards and 7 touchdowns and Kyle Monangai has 731 rushing yards and 5 TDs. DJ Moore has a team-high 48 catches for 664 yards and 6 TDs and Rome Odunze has 44 catches for 551 yards and 6 TDs as well and Colston Loveland has 528 receiving yards and 4 TDs. Luther Burden III has 36 catches for 479 yards and two more Bears have 300+ receiving yards respectively this season. On defense, Tremaine Edmunds leads the Bears with 95 total tackles including 47 solo tackles and 4 interceptions while Kevin Byard III has a team-high 6 interceptions. Montez Sweat also has a team-high 9.5 sacks as well. As a unit, Chicago’s defense has combined for 31 sacks and 21 interceptions so far this season.

Why the Chicago Bears will win

• The Bears have won four of their last five games as underdogs against NFC opponents.
• The 49ers have lost each of their last five games without Kendrick Bourne.
• The 49ers have failed to cover the spread in 13 of their last 14 home games following a win.
• The Bears have covered the spread in six of their last seven games against teams that held a winning record.

Chicago Bears Player Prop Facts

• D.J. Moore has scored at least one touchdown in each of his last three appearances in games with a total points line of at least 50.0.
• D’Andre Swift has recorded 58+ rushing yards in each of the Bears’ last seven games against NFC opponents.
• Colston Loveland has recorded 28+ receiving yards in each of the Bears’ last nine games.
• D’Andre Swift has recorded 78+ rushing and receiving yards in seven of the Bears’ last eight games against NFC opponents.
• Heading into Week 17, Tremaine Edmunds has recorded the equal-most interceptions in a single game this season (2 vs Cowboys, Week 3).

San Francisco 49ers Recap

The San Francisco 49ers come into this game looking to add on to their 48-27 win over Indianapolis last time out to sit at 11-4 this season. After this game, San Francisco will head home for a game against the Seattle Seahawks to close out the regular season. 

49ers Win 5 Straight

Mac Jones has thrown for 2,151 yards, 13 touchdowns and 6 interceptions on 69.6% passing while Brock Purdy has thrown for 1,737 yards, 17 touchdowns and 8 interceptions on 68.8% passing. Christian McCaffrey has a team-high 1,039 rushing yards and 9 TDs while also leading the 49ers in receiving with 92 grabs for 849 yards and 7 touchdowns. Ricky Pearsall has 443 receiving yards and 31 receptions while Kendrick Bourne has 499 receiving yards and Jauan Jennings has 566 receiving yards and 8 TDs. George Kittle also has 599 receiving yards and 52 catches along with 7 touchdowns this season. Three more 49ers have 150+ receiving yards as well on the year. On defense, Dee Winters has a team-high 92 total tackles. Bryce Huff and Clelin Ferrell each have a team-high 4 sacks. As a unit, San Francisco’s defense has combined for 18 sacks and 6 interceptions so far this season. 

Why the San Francisco 49ers will win

• The Bears have lost each of their last 15 games against NFC opponents on a winning streak.
• The favorites have won each of the 49ers’ last nine Week 17 games.
• The favorites have covered the spread in seven of the 49ers’ last eight games.
• The Bears have failed to cover the spread in each of their last five games in California.

San Francisco 49ers Player Prop Facts

• Jauan Jennings has scored at least one touchdown in each of the 49ers’ last five games following a win.
• Brock Purdy has recorded 267+ passing yards in each of his last four appearances against NFC North opponents.
• Brock Purdy has recorded 23+ completions in each of the 49ers’ last four December games.
• Brian Robinson has recorded 24+ rushing yards in each of his seven previous December appearances against NFC opponents.
• Kendrick Bourne has recorded 30+ rushing and receiving yards in each of his last six appearances in games with a total points line of at least 50.0.
• Kendrick Bourne has recorded 30+ receiving yards in each of his last six appearances in games with a total points line of at least 50.0.
• Heading into Week 17, Brock Purdy has recorded the equal-most passing touchdowns in a single game this season (5 vs Colts, Week 16).

Total Points Facts

• Seven of the 49ers’ last eight home games against NFC North opponents have gone OVER the total points line.
• Seven of the Bears’ last eight Sunday road games have gone OVER the total points line.
• Three of the last four Sunday games at Levi’s Stadium have gone OVER the total points line.

49ers vs Bears Prediction

I’m on the 49ers here. I get that the Bears have played a ton of close games this season, good and bad, and they could easily do so here with them fighting for the division. However, the 49ers just keep finding ways to win by margin, winning their last five games by an average of 16.4 PPG. San Fran is just in playoff form right now, and they aren’t a team I’m trying to step in front of unless I have a good reason to. Give me San Francisco here.