San Francisco 49ers vs Denver Broncos Prediction 10/4/26 NFL Picks Today

The Denver Broncos and the San Francisco 49ers meet in week 4 NFL action from Levi’s Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Denver Broncos vs. San Francisco 49ers prediction.

Denver Broncos Recap

The Denver Broncos come into this game looking to add on to their 30-26 win over the Los Angeles Rams last time out to improve to 2-1 on the year. After this game, the Broncos will head on the road for a matchup against the Los Angeles Chargers.

Broncos Win Back-To-Back Games

Bo Nix has thrown for 605 yards, 4 touchdowns and 3 interceptions on 60.2% passing while J.K. Dobbins leads Denver in rushing with 121 yards and 0 touchdowns through 3 games this season. Jonah Coleman sits behind Dobbins on the ground with 39 yards and 1 TD. Jaylen Waddle leads the Broncos in receiving with 150 yards and 11 catches along with 0 TDs, while Pat Bryant trails with 86 yards and 6 catches. On defense, Alex Singleton has a team-high 33 tackles while Denver’s defense as a whole has combined for 8 sacks and 4 interceptions through 3 games this season.

San Francisco 49ers Recap

The San Francisco 49ers come into this game looking to build on their 36-30 win over Arizona last time out to sit at 3-0 on the year. After this game, San Francisco will head on the road for a game against the Seattle Seahawks.

49ers Looking To Stay Undefeated

Brock Purdy has thrown for 789 yards, 9 touchdowns and 1 interception on 72.3% passing while Christian McCaffrey leads San Francisco in rushing with 166 yards and 3 touchdowns through 3 games this season. Kaelon Black sits behind McCaffrey on the ground with 107 yards and 0 TDs. George Kittle leads the 49ers in receiving with 174 yards and 12 catches along with 3 TDs, while Deebo Samuel Sr. trails with 159 yards and 9 catches. On defense, Fred Warner has a team-high 33 tackles while San Francisco’s defense as a whole has combined for 6 sacks and 1 interception through 3 games this season.

Denver Broncos @ San Francisco 49ers Betting Trends: Week 4

Why the San Francisco 49ers will win

• The 49ers have won each of their last seven Sunday games.
• The Broncos have lost each of their last four road games against NFC West opponents.
• The home team has covered the spread in each of the Broncos’ last seven games.
• The Broncos have failed to cover the spread in each of their last four games without Nik Bonitto.
• The 49ers have won the first half in each of their last nine games as favorites.
• The 49ers have won the first quarter in eight of their last nine Week 4 games.
• The 49ers have scored the first touchdown in six of their last seven Sunday games.

Why the Denver Broncos will win

• The Broncos have won each of their last 10 games against NFC opponents.
• The 49ers have lost each of their last six October games as favorites against AFC opponents.
• The 49ers have failed to cover the spread in each of their last eight games as favorites against AFC West opponents.
• The Broncos have covered the spread in each of their last six Sunday games as underdogs.
• The Broncos have won the first quarter in three of their last four road games against NFC opponents.
• The Broncos have scored the first touchdown in each of their last five Week 4 games.
• The 49ers have lost the first half in each of their last five October home games against AFC opponents.

Total Points Facts

• Each of the 49ers’ last six Sunday games played on the West Coast have gone OVER the total points line.
• Seven of the Broncos’ last eight Sunday games as road underdogs have gone UNDER the total points line.
• Five of the last six Sunday games at Levi’s Stadium have gone OVER the total points line.

San Francisco 49ers Player Prop Facts

• George Kittle has scored at least one touchdown in each of his last five appearances in Sunday games played on the West Coast.
• Brock Purdy has recorded 21+ rushing yards in each of the 49ers’ last seven games.
• George Kittle has recorded 67+ receiving yards in each of his last seven appearances with the 49ers as favorites.
• Brock Purdy has recorded 287+ passing yards in each of his last six Sunday home appearances.
• Deebo Samuel has recorded 72+ rushing and receiving yards in four of his last five Week 4 appearances.
• Heading into Week 4, Brock Purdy ranks T1st in the NFL in passing touchdowns (9) this season.

Denver Broncos Player Prop Facts

• Courtland Sutton has scored the last touchdown in three of the Broncos’ last four October games as underdogs.
• Courtland Sutton has scored a touchdown in each of the Broncos’ last four Week 4 games.
• RJ Harvey has recorded 18+ rushing yards in 10 of his last 11 appearances.
• Evan Engram has recorded 28+ receiving yards in each of his last 16 October appearances.
• RJ Harvey has recorded 47+ rushing and receiving yards in each of the Broncos’ last eight games following a home win.
• Bo Nix has recorded 242+ passing yards in seven of the Broncos’ last eight games against NFC opponents.
• Jarrett Stidham has recorded 17+ completions in each of his five previous appearances as a starter.
• Heading into Week 4, Talanoa Hufanga has recorded the equal-most interceptions in a single game this season (2 vs Rams, Week 3).

Matchup/League Facts

• Heading into Week 4, the 49ers rank 1st in the NFL in 3rd down percentage (63.0%) this season.
• Heading into Week 4, the 49ers rank 1st in the NFL in red zone percentage (90.0%) this season.
• Broncos – six different players have recorded 1.0 sacks or more in a game this season – equal-most in the NFL, heading into Week 4.
• Heading into Week 4, the Broncos rank T1st in the NFL in interceptions (4) this season.

Denver Broncos vs. San Francisco 49ers Prediction

I’m on the Broncos and the points in this one. I get the allure of backing the 49ers, but they’re banged up like nobody’s business, and this is a Broncos team that lokoed really solid offensively once they woke up in the second half against the Rams. I think the Broncos come out with a bigger sense of urgency here, and I think the Broncos at least cover if not win outright. Give me the Broncos.