LA Chargers (2-1) vs. San Francisco 49ers (1-1)
August 23, 2025 8:30 pm EDT
The Line: San Francisco 49ers +1.5; Over/Under: 35.5
(Get latest betting odds)
The Los Angeles Chargers and the San Francisco 49ers meet in week 3 NFL Preseason action from Levi’s Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a 49ers vs Chargers Prediction.
Los Angeles Chargers Recap
The Los Angeles Chargers come into this game looking to rebound from a 23-22 loss at the hands of the Los Angeles Rams last time out to sit at 2-1 this preseason. After this game, the Chargers will kick off the regular season in a game against the Kansas City Chiefs.
Chargers Looking To Rebound
Trey Lance threw for 121 yards on 7 of 15 passing while Taylor Heinicke threw for 56 yards on 6 of 11 passing. Lance also rushed for a team-high 25 rushing yards while Raheim Sanders had a rushing TD. Tre Harris had a team-high 6 catches for 85 yards while KeAndre Lambert-Smith had 66 receiving yards as well. On defense, Myles Purchase led the way for the Chargers with 9 total tackles including 6 solo tackles while Trikweze Bridges had 8 total tackles with a team-high 7 solo tackles. Tre’Mon Morris-Brash had a sack while TeRah Edwards had an interception as well in the losing effort.
San Francisco 49ers Recap
The San Francisco 49ers come into this game looking to improve on their 22-19 win over the Las Vegas Raiders last time out to sit at 1-1 in the preseason. After this game, the 49ers will begin the NFL regular season against the Seattle Seahawks.
49ers Looking To Finish Preseason Ahead
Mac Jones threw for 135 yards and an INT on 13 of 16 passing while Carter Bradley threw for 96 yards on 8 of 13 passing. Ke’Shawn Vaughn rushed for a team-high 24 yards and Corey Kiner rushed for 23 yards as well. Robbie Chosen had a team-high 5 receptions for 92 yards while Demarcus Robinson had 3 receptions for 44 yards and Ricky Pearsall had 3 grabs for 42 yards. On defense, Nick Martin had a team-high 6 total tackles including 5 solo tackles and a sack while Chazz Surratt had 6 total tackles and 5 solo tackles as well. Trevis Gipson, Demone Harris and Chase Lucas each had a sack with Lucas and Jaylen Mahoney each had an interception.
49ers vs Chargers Prediction
I’m looking at the Chargers here. I just think the Chargers are the better lineup when it comes to the depth within the team, including depth at the most important position for me, the quarterback position. Furthermore, I just feel like I can’t get behind any team that has Mac Jones as an option on their depth chart. Give me Los Angeles in this one.
