San Francisco 49ers vs Miami Dolphins Prediction 9/20/26 NFL Picks Today

The Miami Dolphins and the San Francisco 49ers meet in week 2 NFL action from Levi’s Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Miami Dolphins vs. San Francisco 49ers prediction.

Miami Dolphins Recap

The Miami Dolphins come into this game looking to bounce back from a 27-13 loss at the hands of the Las Vegas Raiders last time out to improve to 0-1 on the year. After this game, Miami will head home for a game against the Kansas City Chiefs.

Dolphins Looking For Huge Road Upset

Malik Willis has thrown for 220 yards, 0 touchdowns and 1 interception on 55.6% passing while also leading the Dolphins in rushing with 39 rushing yards and 1 touchdown so far this season. De’Von Achane sits behind Willis on the ground with 36 yards and 0 TDs. Caleb Douglas leads Miami in receiving with 94 yards and 5 catches along with 0 touchdowns, while Malik Washington trails with 53 yards on 3 catches. On defense, Jacob Rodriguez has a team-high 14 total tackles while Miami’s defense has yet to record a sack, though they have combined for 0 sacks and 2 interceptions so far this season.

San Francisco 49ers Recap

The San Francisco 49ers come into this game looking to add on to their 27-7 win over the Rams last time out in Australia to sit at 1-0 on the year. After this game, the 49ers will take on the Arizona Cardinals in a matchup at home.

49ers Looking For Solid Showing In Home Opener

Brock Purdy has thrown for 205 yards, 3 touchdowns and 1 interception on 73.5% passing while Christian McCaffrey leads the 49ers in rushing with 68 rushing yards and 0 touchdowns so far this season. Kaelon Black sits right behind McCaffrey on the ground with 65 yards and 0 TDs. Demarcus Robinson leads San Francisco in receiving with 50 yards and 2 catches along with 1 touchdown, while Mike Evans and Deebo Samuel Sr. trail closely with 49 and 48 yards respectively. On defense, Fred Warner has a team-high 11 total tackles while San Francisco’s defense has yet to record a sack, though they have combined for 0 sacks and 1 interception so far this season.

Miami Dolphins @ San Francisco 49ers Betting Trends: Week 2

Why the San Francisco 49ers will win

• The 49ers have won each of their last 11 home games when playing with a rest advantage.
• The Dolphins have lost seven of their last eight games in September.
• The 49ers have covered the spread in each of their last four games following a Division game.
• The Dolphins have failed to cover the spread in eight of their last 10 games as road underdogs.
• The 49ers have won the first quarter in each of their last nine home games against teams that held a losing record.
• The 49ers have scored the first touchdown in six of their last seven Week 2 games.
• The 49ers have won the first half in each of their last nine home games against teams that held a losing record.

Why the Miami Dolphins will win

• The road team has won each of the Dolphins’ last nine Week 2 games.
• The 49ers have lost each of their last three games as favorites without Deebo Samuel.
• The 49ers have failed to cover the spread in 15 of their last 16 home games following a win.
• The road team has covered the spread in eight of the Dolphins’ last nine Week 2 games.
• The underdogs have won the first quarter in three of the last four games between the Dolphins and 49ers.
• The Dolphins have scored the first touchdown in four of their last five road games against NFC West opponents.
• The road team has won the first half in seven of the Dolphins’ last eight Week 2 games.

Total Points Facts

• Each of the Dolphins’ last six games without Greg Dulcich have gone OVER the total points line.
• Seven of the 49ers’ last eight home games against AFC opponents have gone OVER the total points line.
• Three of the last four Sunday games at Levi’s Stadium have gone OVER the total points line.

San Francisco 49ers Player Prop Facts

• Deebo Samuel has scored the last touchdown in four of his last five September appearances.
• Mike Evans has scored the first touchdown in three of his last four September home appearances.
• Mike Evans has scored at least one touchdown in each of his last six appearances against AFC East opponents.
• Deebo Samuel has recorded 44+ receiving yards in each of his last eight September appearances with the 49ers as favorites.
• Deebo Samuel has recorded 44+ rushing and receiving yards in each of his 13 previous September appearances with the 49ers as favorites.
• Brock Purdy has recorded 244+ passing yards in 10 of the 49ers’ last 11 home games as heavy favorites (>-7.0 points).
• Brock Purdy has recorded 16+ rushing yards in each of his last six appearances following a road win.
• Brock Purdy has recorded 20+ completions in each of his last five Sunday home appearances.
• Heading into Week 2, Demarcus Robinson ranks T1st in the NFL in 20+ yard receiving touchdowns (1) this season.

Miami Dolphins Player Prop Facts

• De’Von Achane has scored two touchdowns in three of his last four appearances in day games against teams that held a winning record.
• De’Von Achane has scored at least one touchdown in eight of the Dolphins’ last nine games following a road loss.
• De’Von Achane has recorded 67+ rushing yards in nine of his last 10 Sunday appearances.
• Jalen Tolbert has recorded 11+ receiving yards in 15 of his last 16 Sunday appearances with his team as an underdog.
• Heading into Week 2, Greg Dulcich ranks T1st amongst qualified players for catch rate (100.0%) this season.

Matchup/League Facts

• Heading into Week 2, the 49ers rank 1st in the NFL in points allowed per game (7.0) this season.
• Heading into Week 2, the 49ers rank T1st in the NFL in Q1 win percentage (100.0) this season.
• Heading into Week 2, the Dolphins have recorded the longest kickoff return this season (79 yards).
• Heading into Week 2, the Dolphins rank T1st in the NFL in average points against in fourth quarters this season (0.0).

Miami Dolphins vs. San Francisco 49ers Prediction

I’m on the under in this one. I get the case to be made for either side here as the 49ers are heads and shoulders the better team, but we could see a bit of a sluggish performance because we don’t know how the layoff and travel from down under will affect the 49ers even with a few days off. I think this will be a bit of a slugfest and a low-scoring game, so give me the under here.