Seattle Seahawks vs San Francisco 49ers Prediction 10/11/26 NFL Picks Today

The San Francisco 49ers and the Seattle Seahawks meet in week 5 NFL action from Lumen Field on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco 49ers vs. Seattle Seahawks prediction.

San Francisco 49ers Recap

The San Francisco 49ers come into this game looking to add on to their 24-14 win over Denver last time out to sit at 4-0 this season. After this game, the 49ers will head home for a game against the Commanders.

49ers Looking To Stay Unbeaten

Brock Purdy has thrown for 1,007 yards, 11 touchdowns and an interception on 69.9% passing while Christian McCaffrey leads San Francisco in rushing with 218 yards and 4 touchdowns through 4 games this season. Brock Purdy sits behind McCaffrey on the ground with 122 yards. George Kittle leads the 49ers in receiving with 244 yards and 16 catches along with 4 touchdowns, while Mike Evans trails with 213 yards and 17 catches along with 2 touchdowns. On defense, Fred Warner has a team-high 40 tackles while San Francisco’s defense as a whole has combined for 6 sacks and an interception through 4 games this season.

Seattle Seahawks Recap

The Seattle Seahawks come into this game looking to add on to their 30-23 win over the Chargers last time out to sit at 3-1 this season. After this game, Seattle will head on the road for a game against the Denver Broncos.

Seahawks Looking To Defend Home Field

Sam Darnold has thrown for 560 yards, 6 touchdowns and 3 interceptions on 65.2% passing while Emanuel Wilson leads Seattle in rushing with 190 yards and a touchdown through 4 games this season. Jadarian Price sits behind Wilson on the ground with 119 yards. Jaxon Smith-Njigba leads the Seahawks in receiving with 481 yards and 32 catches along with 6 touchdowns, while Cooper Kupp trails with 114 yards and 9 catches along with a touchdown. On defense, Ernest Jones IV has a team-high 41 tackles while Seattle’s defense as a whole has combined for 11 sacks and 6 interceptions through 4 games this season.

San Francisco 49ers @ Seattle Seahawks Betting Trends: Week 5

Why the Seattle Seahawks will win

• The Seahawks have won each of their last 10 games played on the West Coast.
• The 49ers have lost each of their last seven games as underdogs following a win.
• The Seahawks have covered the spread in each of their last six games against teams that held a winning record.
• The 49ers have failed to cover the spread in each of their last six games as underdogs following a win.
• The Seahawks have won the first quarter in each of their last seven games against teams that held a winning record.
• The 49ers have lost the first half in each of their last eight Sunday games as road underdogs.
• The Seahawks have scored the first touchdown in each of their last 10 games as favorites against NFC West opponents.

Why the San Francisco 49ers will win

• The 49ers have won each of their last eight Sunday games.
• The Seahawks have lost each of their last two October games as favorites against NFC opponents.
• The Seahawks have failed to cover the spread in each of their last six Week 5 games.
• The 49ers have covered the spread in each of their last four Sunday road games.
• The 49ers have won the first half in each of their last four October games against NFC West opponents.
• The 49ers have scored the first touchdown in seven of their last eight Sunday games.
• The 49ers have won the first quarter in three of their last four games at Lumen Field against teams that held a winning record.

Total Points Facts

• Seven of the 49ers’ last eight road games without Brock Purdy have gone OVER the total points line.
• Seven of the last eight games between teams from the same division have gone OVER the total points line.
• Each of the Seahawks’ last five October games as home favorites have gone OVER the total points line.

Seattle Seahawks Player Prop Facts

• Rashid Shaheed has scored a touchdown in four of his last five October appearances with his team as a favorite.
• Cooper Kupp has recorded 43+ receiving yards in each of his last 11 October home appearances against NFC opponents.
• Drew Lock has recorded 208+ passing yards in eight of his last 10 home appearances as a starter.
• Rashid Shaheed has recorded 20+ rushing yards in three of the Seahawks’ last four home games against NFC West opponents.
• Cooper Kupp has recorded 51+ rushing and receiving yards in each of his last 11 October home appearances against NFC opponents.
• Drew Lock has recorded 21+ completions in six of his last eight appearances as a starter.
• Heading into Week 5, Drew Lock has recorded the equal-longest completion in a single game this season (82 yards vs Cardinals, Week 2).

San Francisco 49ers Player Prop Facts

• Deebo Samuel has scored the first touchdown in each of his three previous road appearances against the Seahawks.
• Deebo Samuel has scored at least one touchdown in each of his last six appearances with his team as an underdog on the West Coast.
• Deebo Samuel has recorded 12+ rushing yards in each of his last five appearances with the 49ers as underdogs against NFC West opponents.
• Brock Purdy has recorded 244+ passing yards in each of his last six October appearances against NFC opponents.
• Deebo Samuel has recorded 41+ receiving yards in each of his last eight appearances with his team as an underdog against NFC West opponents.
• Deebo Samuel has recorded 60+ rushing and receiving yards in each of his last seven appearances with the 49ers as underdogs against NFC West opponents.
• Heading into Week 5, Brock Purdy ranks T1st in the NFL in passing touchdowns (11) this season.

Matchup/League Facts

• Seahawks – eight different players have recorded 1.0 sacks or more in a game this season – equal-most in the NFL, heading into Week 5.
• Seahawks – five different players have recorded one interception or more in a game this season – most in the NFL, heading into Week 5.
• Heading into Week 5, the 49ers rank 1st in the NFL in 3rd down percentage (57.5%) this season.
• Heading into Week 5, the 49ers rank 1st in the NFL in red zone percentage (84.6%) this season.

San Francisco 49ers vs. Seattle Seahawks Prediction

I’m on the Seahawks here. If they’re fully healthy, the 49ers have a top-5 team in the NFL, but despite the 4-0 start, they’re incredibly banged up and it’s a matchup like this where that lack of health will come back to bite them in the rear. I think Seattle gets to Purdy and the Niners and Seattle gets it done at home here. Give me Seattle.