Texans vs 49ers Prediction 10/26/25 NFL Picks Today

The San Francisco 49ers and Houston Texans meet Sunday in NFL action at NRG Stadium. Here’s a Texans vs 49ers Prediction. This article will include a Texans vs 49ers Pick.

San Francisco 49ers Betting Preview

The San Francisco 49ers beat the Falcons, lost to the Buccaneers, and play the Giants next. The San Francisco 49ers have split their last 4 games. Mac Jones is completing 67 percent of his passes for 1,404 yards, 6 touchdowns, and 4 interceptions. Kendrick Bourne and Christian McCaffrey have combined for 901 receiving yards and 3 touchdowns, while Ricky Pearsall has 20 receptions.

The San Francisco 49ers ground game is averaging 95.3 yards per contest, and Christian McCaffrey leads the way with 465 yards and 3 touchdowns. Defensively, San Francisco is allowing 19.7 points and 317.4 yards per game. Fred Warner leads the San Francisco 49ers with 51 tackles, Bryce Huff has 4 sacks and Renardo Green has 5 pass deflections.

Houston Texans Betting Preview

The Houston Texans beat the Ravens, lost to the Seahawks, and play the Broncos next. The Houston Texans have lost 6 of their last 9 games. C.J. Stroud is completing 64.8 percent of his passes for 1,305 yards, 9 touchdowns, and 4 interceptions. Nico Collins and Dalton Schultz have combined for 623 receiving yards and 3 touchdowns, while Xavier Hutchinson has 13 receptions.

The Houston Texans ground game is averaging 106.2 yards per contest, and Nick Chubb leads the way with 265 yards and 2 touchdowns. Defensively, Houston is allowing 14.7 points and 274.2 yards per game. Kamari Lassiter leads the Houston Texans with 38 tackles, Danielle Hunter has 4 sacks and Jalen Pitre has 3 interceptions.

Why the Houston Texans will win

• The 49ers have lost each of their last six October games as favorites against AFC opponents.
• The underdogs have won three of the 49ers’ last four games.
• The 49ers have failed to cover the spread in 13 of their last 14 games following a win.
• The underdogs have covered the spread in four of the 49ers’ last five games.
• The Texans have won the first half in 10 of their last 11 games in October.
• The Texans have scored the first touchdown in each of their last four Sunday home games.
• The Texans have won the first quarter in four of their last five Sunday games as underdogs.

Why the San Francisco 49ers will win

• The Texans have lost 30 of their last 31 games as underdogs against NFC opponents.
• The 49ers have won 11 of their last 13 games when playing with a rest advantage.
• The Texans have failed to cover the spread in each of their last 11 games when playing with a rest disadvantage.
• The favorites have covered the spread in each of the Texans’ last four games.
• The 49ers have won the first quarter in seven of their last eight games against AFC South opponents.
• The favorites have won the first half in each of the Texans’ last four games.
• The 49ers have scored the first touchdown in each of their last six games as road favorites.

Total Points Facts

• Each of the 49ers’ last six Week 8 games have gone OVER the total points line.
• Seven of the Texans’ last eight home games following a loss have gone UNDER the total points line.
• Seven of the last nine Sunday games at NRG Stadium have gone UNDER the total points line.

Houston Texans Player Prop Facts

• Christian Kirk has recorded 39+ receiving yards in each of his last 15 appearances against NFC opponents.
• Nick Chubb has recorded 43+ rushing yards in each of his 11 previous home appearances against NFC opponents.
• C.J. Stroud has recorded 232+ passing yards in seven of the Texans’ last eight Sunday home games.
• Nico Collins has scored the first touchdown in three of his last four home appearances against NFC opponents.
• Nico Collins has scored a touchdown in eight of his last nine home appearances against teams that held a winning record.
• Christian Kirk has recorded 39+ rushing and receiving yards in each of his last 15 appearances against NFC opponents.
• C.J. Stroud has recorded 22+ completions in each of the Texans’ last four games.
• Heading into Week 8, Jalen Pitre has recorded the equal-most interceptions in a single game this season (2 vs Ravens, Week 5).

San Francisco 49ers Player Prop Facts

• Brock Purdy has recorded 277+ passing yards in each of his last four appearances.
• Christian McCaffrey has scored at least one touchdown in each of his last nine October appearances.
• Brian Robinson has recorded 21+ rushing and receiving yards in nine of his last 10 appearances against AFC opponents.
• Christian McCaffrey has scored two touchdowns in three of his last four Week 8 appearances.
• Christian McCaffrey has recorded 52+ receiving yards in each of the 49ers’ last seven games.
• Brian Robinson has recorded 18+ rushing yards in each of his 12 previous appearances against AFC opponents.
• Brock Purdy has recorded 22+ completions in each of his last six Sunday regular season appearances with the 49ers as road favorites.
• Heading into Week 8, Eddy Pineiro ranks 1st in the NFL in made field goals (17) this season.

Matchup/League Facts

• Heading into Week 8, the Texans rank 1st in the NFL in points allowed per game (14.7) this season.
• Heading into Week 8, the Texans rank 32nd in the NFL in kickoff return yards per game (68.2) this season.
• 49ers – four different players have recorded 80+ receiving yards in a game this season – equal-most in the NFL, heading into Week 8.
• Heading into Week 8, the 49ers rank 1st in the NFL in passing yards per game (271.3) this season.

Texans vs 49ers Prediction

This line is rather surprising. The Texans continue to underachieve offensively, and now there’s a chance they could be without Collins due to a concussion. The Texans have offensive line issues and even without Warner, the 49ers defense is still one of the best in the league and seventh in scoring. The 49ers also have the best passing offense in the league and a difference maker in McCaffrey.

The Texans have less time to prepare for this game as well, and are 2-4 ATS on the season. The 49ers have outright won 2 of the 3 games this season where they’ve been an underdog. Give me the points.