TNF: Tennessee Titans vs San Francisco 49ers 12/23/21 NFL Picks, Predictions, Odds

The Tennessee Titans and San Francisco 49ers clash Thursday night in a week 16 NFL contest at Nissan Stadium in Nashville. The San Francisco 49ers look to stay hot after winning five of their last six games. The Tennessee Titans need a win after losing three of their last four games.

The San Francisco 49ers have won five of their last seven road games. Jimmy Garoppolo is completing 67.4 percent of his passes for 3,172 yards, 18 touchdowns and 8 interceptions. Deebo Samuel and George Kittle have combined for 1,938 receiving yards and 11 touchdowns, while Brandon Aiyuk has 42 receptions. The San Francisco 49ers ground game is averaging 126.6 yards per contest, and Elijah Mitchell leads the way with 759 yards and 5 touchdowns. Defensively, San Francisco is allowing 22.4 points and 321.8 yards per game. Fred Warner leads the San Francisco 49ers with 108 tackles, Nick Bosa has 15 sacks and Jimmie Ward has 2 interceptions.

The Tennessee Titans have won five of their last six home games. Ryan Tannehill is completing 66.2 percent of his passes for 3,118 yards, 14 touchdowns and 14 interceptions. Julio Jones and AJ Brown have combined for 984 receiving yards and 3 touchdowns, while Nick Westbrook-Ikhine has 32 receptions. The Tennessee Titans ground game is averaging 142.3 yards per contest, and D’Onta Foreman leads the way with 348 yards and 1 touchdown. Defensively, Tennessee is allowing 22.1 points and 329.2 yards per game. Kevin Byard leads the Tennessee Titans with 73 tackles, Harold Landry III has 11 sacks and Kristian Fulton has 2 interceptions.

The 49ers are 3-8 ATS in their last 11 Thursday games and 5-1 ATS in their last 6 games overall. The Titans are 2-6 ATS in their last 8 Thursday games and 1-4 ATS in their last 5 games overall. The over is 4-1 in 49ers last 5 Thursday games. The over is 29-14-1 in Titans last 44 games overall. The over is 4-0 in the last 4 meetings.

I love my home dogs in a short week, but the Tennessee Titans are watching their season slip away a bit with losses in three of their last four games, and now AJ Brown and Julio Jones are dinged up. The banged up Titansoffense has scored no more than 20 points in four straight games. The San Francisco 49ers are playing their best ball of the season, and they’ve actually been better on the road than at home this year anyway. The Titans are limited on offense with their injury situation, and the 49ers are sixth in both total defense and passing defense. This should be a grind out victory for the road team.