Sabres vs Blues Prediction 11/6/25 NHL Picks Today
St. Louis Blues (4-8-2) vs. Buffalo Sabres (5-4-4)
November 6, 2025 7:00 pm EDT
The Line: Buffalo Sabres -130 / St. Louis Blues 110; Over/Under: 6.5
(Get latest betting odds)
The St. Louis Blues and Buffalo Sabres meet Thursday in NHL action at the KeyBank Center. Here’s a Sabres vs Blues Prediction. This article will include a Sabres vs Blues Pick.
St. Louis Blues Betting Preview
The St. Louis Blues lost to the Capitals, beat the Oilers, and they play the Capitals next. The Blues have lost 8 of their last 9 games.
The St. Louis Blues are averaging 2.71 goals per game and are scoring on 23.1 percent of their power play opportunities. Jake Neighbours leads St. Louis with 6 goals, Robert Thomas has 6 assists, and Jordan Kyrou has 32 shots on goal. Defensively, the St. Louis Blues are allowing 4.14 goals per game and are killing 67.6 percent of their opponent’s power plays. Jordan Binnington has allowed 32 goals on 227 shots faced, and Joel Hofer has given up 22 goals on 134 shots.
Buffalo Sabres Betting Preview
The Buffalo Sabres beat the Capitals, lost to the Mammoth, and they play the Hurricanes next. The Sabres have lost 4 of their last 5 games.
The Buffalo Sabres are averaging 2.85 goals per game and are scoring 19.1 percent of their power play opportunities. Alex Tuch leads Buffalo with 5 goals, Rasmus Dahlin has 8 assists, and Tage Thompson has 55 shots on goal. Defensively, the Buffalo Sabres are allowing 3.08 goals per game and are killing 90.9 percent of their opponent’s power plays. Alex Lyon has given up 28 goals on 329 shots faced, and Ukko-Pekka Luukkonen has allowed 7 goals on 57 shots.
Why the Buffalo Sabres will win
- The Blues have lost each of their last six road games on the second leg of a back-to-back.
- The home team has won eight of the Sabres’ last 10 games.
- The Blues have failed to cover the puck line in each of their last three games against Atlantic Division opponents.
- The Sabres have covered the puck line in six of their last eight home games against Central Division opponents.
- The Blues have lost the second period in each of their last five road games against Eastern Conference opponents when trailing after the first period.
Why the St. Louis Blues will win
- The underdogs have won nine of the Blues’ last 12 games.
- The Sabres have lost four of their last six games as home favorites after coming off overtime.
- The underdogs have covered the puck line in each of the Sabres’ last six games.
- The Sabres have failed to cover the puck line in six of their last seven games as favorites after coming off overtime.
- The Sabres have lost the second period in each of their last nine home games against Western Conference opponents when leading after the first period.
Total Goals Facts
- Each of the last nine night games between the Blues and Sabres have gone OVER the total goals line.
- Seven of the Blues’ last eight road games have gone OVER the total goals line.
- The ‘Over 2.5 Goals Period 1’ market has hit in four of the last five games between the Blues and Sabres.
- The ‘Over 1.5 Goals Period 1′ market has hit in six of the Blues’ last seven games against Atlantic Division opponents.
Buffalo Sabres Player Prop Facts
- Alex Tuch has scored a goal in seven of the Sabres’ last eight games as favorites.
- Jack Quinn has recorded an assist in each of his last five appearances with the Sabres as home favorites against Central Division opponents.
- Alex Tuch has recorded at least one point in each of the Sabres’ last eight games as favorites.
St. Louis Blues Player Prop Facts
- Jordan Kyrou has scored a goal in each of the Blues’ last four games against Atlantic Division opponents.
- Robert Thomas has recorded at least one assist in each of his last five appearances against Atlantic Division opponents.
- Brayden Schenn has recorded at least one point in each of the Blues’ last six games against the Sabres.
Matchup/League Facts
- The Buffalo Sabres rank 1st in the league in penalty kill percentage this season (90.91%).
- The Buffalo Sabres rank T1st in the league for power play goals against this season (4).
- The St. Louis Blues rank 32nd in the league for goals against per game this season (4.14).
- The St. Louis Blues rank 30th in the league in penalty kill percentage this season (67.57%).
Sabres vs Blues Prediction
The Sabres have seen all 5 of the twins this season come at home, and they’re running into a Blues team that’s won one game over the last several weeks. The Blues have been atrocious defensively this season, and those sorts of things usually don’t improve on the road. The Sabres have earned points in 7 straight games, and they have to view this as a fine spot to keep stacking away in the standings. The price is reasonable. Give me the Sabres at home.