The San Francisco 49ers and the Arizona Cardinals meet in a week 15 NFC West matchup in NHL action from State Farm Stadium on Sunday afternoon. First meets worst in the division on Sunday, who comes out on top? Let’s take a look and give out a 49ers vs. Cardinals Prediction.

San Francisco 49ers Team Preview

The San Francisco 49ers come into this game looking to build on their 10-3 mark this season following a 28-16 win over Seattle last time out. Brock Purdy has thrown for 3,553 yards, 25 touchdowns and 7 interceptions on 70.2% passing while Christian McCaffrey has a team-high 1,177 rushing yards and 12 touchdowns. Brandon Aiyuk has a team-high 1,053 receiving yards and 56 receptions with 6 touchdowns while George Kittle has 53 grabs for 811 yards and 6 touchdowns. Deebo Samuel has 45 receptions for 739 receiving yards and 4 TDs while Christian McCaffrey has 52 receptions for 437 yards as well this season. On defense, Fred Warner has a team-high 107 total tackles and 4 interceptions while Nick Bosa has a team-high 9.5 sacks and Javon Hargrave has 6 sacks. Arik Armstead also has 5 sacks while Talanoa Hufanga also has 3 interceptions this season.

San Francisco 49ers Team Facts

• The 49ers have won each of their last 11 games against NFC West opponents.
• The 49ers have covered the spread in each of their last seven games following a Division win.
• The 49ers have scored the first touchdown in each of their last nine games following a win.
• The 49ers have won the first half in each of their last eight games following a win.
• The underdogs have won the first quarter in each of the 49ers’ last two games.

Arizona Cardinals Team Preview

The Arizona Cardinals come into this one looking to build on a 24-10 win over Pittsburgh last time out prior to their bye week. Kyler Murray has thrown for 864 yards, 3 touchdowns and 2 interceptions on 60.8% passing. James Conner leads the Cardinals in rushing with 631 rushing yards with 4 TDs as well. Trey McBride leads the Cardinals in receiving with 56 grabs for 610 yards while Marquise Brown has 51 receptions for 574 yards and 4 TDs and Michael Wilson has 28 catches for 435 yards and 2 scores. On defense, Kyzir White has a team-high 90 total tackles while Dennis Gardeck has a team-high 5 sacks and Jalen Thompson has 3 interceptions as well on the year.

Arizona Cardinals Team Facts

• The Cardinals have lost each of their last eight games following a win.
• The Cardinals have failed to cover the spread in each of their last eight December home games against NFC West opponents.
• The Cardinals have lost the first half in each of their last seven games following a win.
• The Cardinals have won the first quarter in each of their last four games as home underdogs against NFC opponents.
• Each of the Cardinals’ last six home games have gone OVER the total points line.

Matchup/League Facts

• The Cardinals rank 32nd in the NFL in 4th down percentage this season (32.0%).
• The Cardinals rank 31st in the NFL in time of possession per game this season (27:53).
• The 49ers rank 1st in the NFL in points allowed per game this season (15.8).
• The 49ers rank 1st in the NFL in rushing yards allowed per game this season (78.3).

49ers vs. Cardinals Prediction

It’s a thick line here, but it’s 49ers or pass for me here. Now that San Francisco is back to being fully healthy, this team looks borderline unstoppable and are looking like the clear cut favorite to make it out of the NFC. Arizona got a nice win over Pittsburgh and are rested and prepared for this game, but the Niners are just on another level right now. Give me San Francisco laying the points.