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Pirates vs Diamondbacks Prediction 7-25-25 MLB Picks

Arizona Diamondbacks (50-53) vs. Pittsburgh Pirates (42-61)
July 25, 2025 10:40 pm EDT
The Line: Pittsburgh Pirates 102 / Arizona Diamondbacks -124; Over/Under: 9
(Get latest betting odds)

The Arizona Diamondbacks and Pittsburgh Pirates meet Friday in MLB action at PNC Park. Here’s a Pirates vs Diamondbacks Prediction. This article will include a Pirates vs Diamondbacks Pick.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 50-53 on the year and play the Tigers, Athletics, and Padres next. The Arizona Diamondbacks are batting .253 on the season, have a .329 OBP, and a .446 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.58 ERA and a 1.33 WHIP. Geraldo Perdomo leads the Arizona Diamondbacks with 106 hits and 72 RBI, while Eugenio Suarez and Lourdes Gurriel Jr. have combined for 184 hits and 134 RBI.

Ryne Nelson gets the ball for the Arizona Diamondbacks, and he is 6-2 with a 3.52 ERA and 69 strikeouts this season. Nelson is 1-0 with a 3.09 ERA and 11 strikeouts in his career against the Pittsburgh Pirates.

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 42-61 on the year and play the Giants, Rockies, and Giants next. The Pittsburgh Pirates are batting .232 on the season, have a .301 OBP, and a .342 slugging percentage. The Pittsburgh Pirates pitching staff has a 3.84 ERA and a 1.21 WHIP. Bryan Reynolds leads the Pittsburgh Pirates with 90 hits and 50 RBI while Ke’Bryan Hayes and Andrew McCutchen have combined for 167 hits and 66 RBI.

Mike Burrows gets the ball for the Pittsburgh Pirates, and he is 1-3 with a 4.70 ERA and 48 strikeouts this season. This will be Burrows’ second career game against the Arizona Diamondbacks.

Why the Pittsburgh Pirates will win

  • The Pirates have won each of their last six games as home underdogs.
  • The Diamondbacks have lost each of their last five games as road favorites against NL Central opponents.
  • The Pirates have covered the run line in each of their last eight games as home underdogs against National League opponents.
  • The Diamondbacks have failed to cover the run line in each of their last seven games as road favorites against National League opponents following a loss.
  • The Pirates have led after 5 innings in each of their last six games as home underdogs.
  • The Diamondbacks have lost the first inning in each of their last three night games against opponents that held a losing record.
  • The Pirates have led after 3 innings in each of their last six games as home underdogs.

Why the Arizona Diamondbacks will win

  • The Pirates have lost each of their last eight night games against teams that held a losing record.
  • The Diamondbacks have won nine of their last 10 night games against NL Central opponents following a home loss.
  • The Diamondbacks have covered the run line in 10 of their last 11 night games against the Pirates following a loss.
  • The Pirates have failed to cover the run line in five of their last six home games against teams that held a losing record.
  • The Diamondbacks have won the first inning in four of their last five games.
  • The Diamondbacks have led after 3 innings in each of their last five games against National League opponents.
  • The Pirates have trailed after 5 innings in each of their last seven games as home underdogs against NL West opponents.

Pittsburgh Pirates Player Prop Facts

  • Andrew McCutchen has hit a home run in each of the Pirates’ last two games against NL West opponents.
  • Bryan Reynolds has recorded a Double in five of the Pirates’ last six games as underdogs against NL opponents.
  • Andrew McCutchen has recorded at least one hit in each of his last 16 home appearances against NL opponents.
  • Oneil Cruz ranks T1st in the league in Steals (33) this season.

Arizona Diamondbacks Player Prop Facts

  • Eugenio Suarez has hit at least one home run in four of the Diamondbacks’ last five games against NL Central opponents.
  • James McCann has recorded a Double in each of his last three appearances against NL opponents that held a losing record.
  • Gabriel Moreno has recorded at least one hit in each of his last 11 appearances in night games against teams that held a losing record.
  • Ryne Nelson has recorded a win in three of his last four road appearances against NL opponents that held a losing record.
  • Eugenio Suarez ranks 4th in the league in Home Runs (36) this season.

Pirates vs Diamondbacks Prediction

Nelson has been solid this season for the Diamondbacks, but they were just swept by the Astros and now traded away one of their best players in Josh Naylor. Are the Diamondbacks selling? That can’t be great for the locker room. Burrows isn’t a pitcher I’m excited to get behind, but the Pirates just swept one of the best teams in baseball. I wouldn’t be shocked if the Diamondbacks come out flat. Give me the Pirates at home on Friday night.

Randy Chambers's Free Pick: Pittsburgh Pirates +102

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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