Purdue vs USC Prediction Football Picks Today 9/13/25

The USC Trojans and Purdue Boilermakers meet Saturday in college football action at Ross-Ade Stadium. Here’s a Purdue vs USC Prediction. This article will include a Purdue vs USC Pick.

USC Trojans Betting Preview

The USC Trojans beat Missouri State and Georgia Southern, and they play Michigan State next. The USC Trojans have won 6 of their last 8 games. Jayden Maiava is completing 73.8 percent of his passes for 707 yards, 6 touchdowns, and 0 interceptions. Makai Lemon and Ja’Kobi Lane have combined for 372 receiving yards and 3 touchdowns, while Lake McRee has 4 receptions.

The USC Trojans ground game is averaging 271 yards per contest, and Waymond Jordan leads the way with 209 yards and 2 touchdowns. Defensively, USC is allowing 16.5 points and 300.5 yards per game. Eric Gentry leads the USC Trojans with 13 tackles, Braylan Shelby has 2 sacks and Bishop Fitzgerald has 1 interception.

Purdue Boilermakers Betting Preview

The Purdue Boilermakers beat Ball State and Southern Illinois, and they play Notre Dame next. The Purdue Boilermakers have lost 11 of their last 13 games. Ryan Browne is completing 65.3 percent of his passes for 481 yards, 4 touchdowns, and 1 interception. Arhmad Branch and Michael Jackson III have combined for 211 receiving yards and 3 touchdowns, while Devin Mockobee has 4 receptions.

The Purdue Boilermakers ground game is averaging 154 yards per contest, and Devin Mockobee leads the way with 185 yards and 3 touchdowns. Defensively, Purdue is allowing 8.5 points and 243 yards per game. Tahj Ra-El leads the Purdue Boilermakers with 14 tackles, CJ Nunnally IV has 2 sacks and Smiley Bradford has 1 pass deflection.

USC Trojans @ Purdue Boilermakers Betting Trends: Week 3

Why the Purdue Boilermakers will win

• USC has lost four of its last five games as a road favorite.
• The home team has won each of Purdue’s last four games.
• USC has failed to cover the spread in seven of its last eight games as a road favorite.

Why the USC Trojans will win

• USC has won each of its last 11 September games against non-AP-ranked teams.
• Purdue has lost each of its last nine games against conference opponents.
• Purdue has failed to cover the spread in seven of its last eight games in Indiana.
• USC has covered the spread in each of its last five games against non-AP-ranked teams.
• Purdue has lost the first half in each of its last eight games against conference opponents.

Total Points Facts

• Each of USC’s last four games have gone OVER the total points line.
• Four of Purdue’s last five home games against non-AP-ranked teams have gone UNDER the total points line.

Purdue Boilermakers Player Prop Facts

• Heading into Week 3, Devin Mockobee ranks T1st amongst qualified players for catch rate (100.0%) this season.

USC Trojans Player Prop Facts

• Makai Lemon has recorded 75+ receiving yards in four consecutive games – equal-longest streak in the FBS, heading into Week 3.

Matchup/League Facts

• Purdue ranks T1st among FBS teams for Q2 opponent points per game this season (0.0).
• Purdue ranks T1st among FBS teams for Q3 opponent points per game this season (0.0).
• USC ranks 1st among FBS teams for points per game this season (66.0).
• USC ranks T1st among FBS teams for Q4 opponent points per game this season (0.0).

Purdue vs USC Prediction

Give Purdue credit for getting off to an undefeated start, but beating up on Ball State and Southern Illinois only gets you so far. I need to see more after Purdue ended last season with 11 straight losses. USC is not only head and shoulders the more talented team, but it’s also covered 5 straight games as a double-digit favorite.

Purdue has also had issues running the ball despite two straight wins, and that’s not going to fly against a step in competition. USC is clicking on all cylinders offensively through two games. This will get ugly if Purdue is still the team from last season. Thick line, but give me USC in a beat down.