Draftkings NFL Showdown Picks: 49ers vs. Giants 11/2/25

This Sunday afternoon, the NFL presents Draftkings football fans with a regular season matchup featuring the San Francisco 49ers and the New York Giants. Let’s take a look at this game from a DFS perspective.

Before we dive into the San Francisco 49ers vs. New York Giants game let’s review the rules for the Draftkings single game showdown contest.

Draftkings Single Game Showdown Contest Rules

You have $50,000 to utilize on five players from either team. However, one of those players will be designated as your team captain. The captain accumulates 1.5 times the standard fantasy points. Additionally, the captain is 1.5 times the standard cost of the flex position.

The remaining four players in your lineup will receive the standard fantasy points. Having stated that, it is highly important for you to identify the correct player for your captain position if you hope to win a large field DFS GPP (guaranteed prize pool) showdown contest.

If you have additional questions regarding the rules for the single game showdown contest, I recommend that you check out the Draftkings website for more details.

*I recommend that all readers review the starting lineups for both teams prior to setting your DFS lineup for this one game slate.

Here are my Draftkings picks for this Sunday afternoon’s 49ers vs. Giants matchup.

Draftkings NFL Showdown Picks

Captain-Christian McCaffrey, Running Back, San Francisco 49ers $12,800

Talented running back Christian McCaffrey has certainly been a standout performer for the San Francisco 49ers in 2025. With that said, how has McCaffrey performed from a data perspective this season? Let’s review McCaffrey’s relevant key player game data from the 2025 NFL regular season to better shed light on the veteran running back’s overall contributions to his team.

In the seven games that running back Christian McCaffrey has played for the San Francisco 49ers in the 2025 NFL regular season, McCaffrey has amassed 490 rushing yards, three rushing touchdowns, 56 receptions, 559 receiving yards and three receiving touchdowns.

Looking at the data just presented more closely, in the seven games that McCaffrey has played this season, McCaffrey has averaged a massive 25.1 Draftkings points.

Last month, in the San Francisco 49ers 16-15 win over the Arizona Cardinals, San Francisco running back Christian McCaffrey played exceptionally well. Let me be more specific. In the San Francisco 49ers defeat of the Cardinals, McCaffrey tallied 52 rushing yards, ten receptions and 88 receiving yards.

Additionally, I like Christian McCaffrey’s matchup in this game. Why? The New York Giants defense has had issues containing the running back position in 2025. Let me be more specific. Upon the completion of eight games played in the 2025 NFL regular season, in relation to the other 31 teams in the league, the New York Giants rank a rather low 26th in total Draftkings points allowed (22.4) to the running back position a game.

As I noted in the rules section above, selecting the correct player at the captain position for a Draftkings NFL Football showdown lineup is absolutely vital if you hope to win a large field GPP (guaranteed prize pool) DFS contest. Keep that in mind as you construct your lineups.

In my view, Christian McCaffrey is the most likely player to post the most Draftkings points in this NFL regular season game. For that specific reason, I am rolling with San Francisco 49ers running back Christian McCaffrey at the captain position for this one game NFL DFS slate.

Flex plays I like to play well in this Sunday afternoon’s NFL regular season contest (Draftkings price noted): Jaxson Dart, Quarterback (New York Giants) $9,200: Tyrone Tracy Jr., Running Back (New York Giants) $8,200: Jauan Jennings, Wide Receiver (San Francisco 49ers) $7,400.