Astros vs Guardians Prediction 6/21/26 MLB Picks Today

In this article we will formulate an Astros vs Guardians prediction for this MLB game on Sunday, June 21st at Daikin Park in Houston, Texas. Let’s take a look at the prediction for this MLB matchup. 

Houston Astros Betting Preview

The Houston Astros are 36-42 this year after they split the first two games in this series by scores of 9-3 and 1-8. In game two, Houston tied the game at one in the second inning, but went scoreless over the last seven innings for the loss. The Astros recorded five hits in the game and they were led by Diaz, who went 1-3 with one RBI. Arrighetti allowed six hits and six earned runs over 6.0 innings for the loss, while Pearson allowed two earned runs in relief. Prior to this series, Houston won two out of three against the Tigers and two out of three against the Royals. 

This season, Houston has a 4.89 ERA with a 1.41 WHIP and a .243 opponent batting average, while they have scored 354 runs with a .243 batting average and a .318 on base percentage. Yordan Alvarez has led the Astros with 24 home runs and 55 RBIs, while Christian Walker has added 18 home runs and 52 RBIs. The projected starting pitcher for Houston is Kai-Wei Teng, who is 3-6 with a 4.31 ERA and a 1.34 WHIP over 54.1 innings pitched this year. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 41-36 this season after they won game two by a score of 8-1 on Saturday night. Cleveland took the lead in the third inning and ran away with the easy victory. The Guardians recorded 10 hits in the game and they were led by Bazzana, who went 4-4 with two home runs and five RBIs. Cantillo allowed four hits and one earned run over 8.0 innings for the win, while Festa closed out the game. Prior to this series, Cleveland lost two out of three against the Brewers, but did win both games against the Tigers before that. 

This season, Cleveland has a 3.81 ERA with a 1.26 WHIP and a .237 opponent batting average, while they have scored 309 runs with a .229 batting average and a .314 on base percentage. Chase DeLauter has led the Guardians with seven home runs and 34 RBIs, while Angel Martinez has added 11 home runs and 33 RBIs. The projected starting pitcher for Cleveland is Slade Cecconi, who is 3-5 with a 4.60 ERA and a 1.40 WHIP over 78.1 innings pitched this season. 

Why the Houston Astros will win

• The Guardians have lost each of their last four road games following a win.
• The Astros have won each of their last four games following a home loss.
• The Astros have covered the run line in each of their last four home games against American League opponents following a home loss.
• The Guardians have failed to cover the run line in each of their last six Sunday games against AL West opponents.
• The Guardians have lost the first inning in each of their last three day games against opponents that held a losing record.
• The Astros have led after 5 innings in four of their last five day games against opponents that held a winning record.
• The Guardians have trailed after 3 innings in four of their last five day games against AL West opponents.

Why the Cleveland Guardians will win

• The Guardians have won four of their last five games as underdogs against the Astros.
• The Astros have lost five of their last six games as home favorites following a loss.
• The Guardians have covered the run line in each of their last nine Sunday day games against the Astros.
• The Astros have failed to cover the run line in 10 of their last 11 games as favorites following a loss.
• The Guardians have won the first inning in three of their last four games at Daikin Park.
• The Guardians have led after 5 innings in seven of their last eight games against opponents that held a losing record.
• The Astros have trailed after 3 innings in seven of their last eight games as favorites against AL Central opponents.

Total Runs Facts

• Seven of the Astros’ last eight day games against AL Central opponents have gone UNDER the total runs line.
• Six of the Guardians’ last seven games as underdogs against AL West opponents have gone OVER the total runs line.
• There has been at least one run scored in the first inning in each of the last seven games between the Guardians and Astros.
• There has been no run scored during the first inning in seven of the Guardians’ last eight day games at Daikin Park.

Houston Astros Player Prop Facts

• Christian Walker has hit at least one home run in three of the Astros’ last four day games against opponents that held a winning record.
• Yainer Diaz has recorded at least one hit in each of his last nine appearances against opponents that held a winning record.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in each of his last four appearances with the Guardians as underdogs against the Astros.
• Jose Ramirez has recorded at least one hit in each of his last 10 appearances against the Astros.

Astros vs Guardians Prediction 

Houston had their mini winning streak snapped on Saturday night, but they have allowed three runs or fewer in three of their last four games. The Astros are 19-21 at home this year, while the Guardians are 22-19 on the road. Cleveland has lost three of their last five games, but they are currently first in the AL Central. The Guardians are starting Cecconi, who has allowed two earned runs or fewer in three straight starts, while Teng has allowed 4+ earned runs in three straight outings. Take the Guardians on the road here.