NY Yankees vs St. Louis Cardinals Prediction 8/5/26 MLB Picks Today

The St. Louis Cardinals and the New York Yankees meet Wednesday in MLB action from Yankee Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a St. Louis Cardinals vs. New York Yankees prediction.

Starting Pitching Matchup

The St. Louis Cardinals will send out Andre Pallante for the start here and Pallante is 11-6 with a 3.72 ERA and 86 strikeouts this season. Will Warren will start for the Yankees and is 8-5 with a 4.14 ERA and 109 strikeouts this season.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to bounce back from a 2-0 loss at the hands of the Yankees on Tuesday to sit at 56-58 this season. After this series, the Cards will head home for a series against the Colorado Rockies.

Cardinals Have Two-Game Win Streak Snapped

Entering Tuesday, Jordan Walker has 123 hits, 23 doubles, 22 home runs and 81 RBIs while Alec Burleson has 124 hits with 27 doubles, 18 home runs and 77 RBIs. JJ Wetherholt has 104 hits with 16 home runs and 41 RBIs while Ivan Herrera has 100 hits with 18 doubles, 12 home runs and 46 RBIs. Nolan Gorman has 39 hits with 7 home runs and 26 RBIs this season. Masyn Winn’s added 90 hits with 14 doubles and 45 RBIs and Nathan Church has 66 hits with 9 home runs and 35 RBIs this season.

New York Yankees Recap

The New York Yankees come into this game looking to build on Tuesday’s win over St. Louis to sit at 64-50 this season. After this series, the Yankees will take on the Atlanta Braves in a series at home.

Yankees Alternate Wins & Losses In 6 Straight

Going into Tuesday, Ben Rice has 106 hits with 19 doubles, 31 home runs and 73 RBIs and Aaron Judge has 53 hits with 10 doubles, 17 home runs and 38 RBIs. Cody Bellinger also has 97 hits with 21 doubles, 3 triples, 11 home runs and 53 RBIs. Jazz Chisholm Jr. also has 81 hits with 14 doubles, 16 home runs and 45 RBIs as well on the year.

St. Louis Cardinals @ New York Yankees Betting Trends: August 5, 2026

• Probable Starting Pitcher: Will Warren      Record this season: 8-5      ERA: 4.14
• Home Record: 4-2
• Last 5 against Cardinals: 0-1

Why the New York Yankees will win

• The Cardinals have lost eight of their last nine games against AL East opponents that held a winning record.
• The Yankees have won four of their last five games against the Cardinals.
• The Cardinals have failed to cover the run line in seven of their last eight night games following a loss.
• The Yankees have covered the run line in four of their last five night games following a home win.
• The Yankees have led after 3 innings in nine of their last 11 home games against National League opponents that held a losing record.
• The Cardinals have trailed after 5 innings in seven of their last eight night games against AL East opponents that held a winning record.

• Probable Starting Pitcher: Andre Pallante      Record this season: 11-6      ERA: 3.72
• Road Record: 6-0
• Last 5 against Yankees: 1-1

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last six Wednesday games as underdogs against AL East opponents.
• The Yankees have lost five of their last six games as home favorites following a win.
• The Yankees have failed to cover the run line in each of their last five games following a win.
• The Cardinals have covered the run line in each of their last six Wednesday games as underdogs against AL East opponents.
• The Yankees have lost the first inning in four of their last five night games against National League opponents.
• The Yankees have trailed after 3 innings in six of their last eight games against opponents that held a losing record.
• The Yankees have trailed after 5 innings in 10 of their last 12 games against opponents that held a losing record.

Total Runs Facts

• Seven of the Cardinals’ last eight road games have gone UNDER the total runs line.
• Five of the last six games between the Cardinals and Yankees at Yankee Stadium have gone OVER the total runs line.
• There has been no run scored during the first inning in six of the Cardinals’ last seven games.
• There has been no run scored during the first inning in five of the last six games between the Cardinals and Yankees at Yankee Stadium.

New York Yankees Player Prop Facts

• Luis Garcia has hit at least one home run in three of his last four appearances with his team as a favorite against NL Central opponents.
• Will Warren has recorded five or more strikeouts in 13 of his last 14 home appearances against opponents that held a losing record.
• Jose Caballero has recorded at least one hit in each of his eight previous appearances against the Cardinals.
• Jazz Chisholm ranks T2nd in the league in Steals (30) this season.

St. Louis Cardinals Player Prop Facts

• Jimmy Crooks has hit a home run in each of his last two road appearances against opponents that held a winning record.
• Andre Pallante has recorded a win in six of his last seven road appearances.
• Andre Pallante has recorded five or more strikeouts in four of his last five appearances against AL opponents.
• Jordan Walker has recorded at least one hit in each of his last nine appearances with the Cardinals as road underdogs against AL East opponents.
• Alec Burleson ranks 7th in the league in Hits (124) this season.

Matchup/League Facts

• The Yankees rank 1st in the league for ERA this season (3.34).
• The Yankees rank 2nd in the league for home runs this season (164).
• The Cardinals rank T27th in the league for doubles this season (154).
• The Cardinals rank 27th in the league for slugging percentage this season (.379).

St. Louis Cardinals vs. New York Yankees Prediction

I’m on St. Louis in this one. I don’t really trust the Yankees offense against righties at the moment, and Will Warren has not been the most consistent on the mound either. At this price, I feel like I have to take a shot on St. Louis here.