Cardinals vs 49ers Prediction 9/27/26 NFL Picks Today

In this article, we will formulate a Cardinals vs 49ers Prediction for this NFL Week 3 game on Sunday, September 27^th. Let’s take a look at the prediction for this NFL matchup.

San Francisco 49ers Preview

The San Francisco 49ers have a 2-0 record this season and are coming off a 35-13 home win against the Miami Dolphins. They will face the Broncos, the Seahawks and the Commanders next. Offensively, the 49ers average 31 points per game, ranking 4th in the NFL, while defensively, they allow 10 points per game, which is 3rd. San Francisco averages 380.5 total yards per game (246 passing and 134.5 rushing), while allowing 287 total yards per game (112 rushing and 175 passing).

Brock Purdy leads the 49ers with 492 passing yards with 80.4% completed passes and five touchdowns. Christian McCaffrey leads the team in rushing yards with 91, while Mike Evans caught 9 passes for a team-high 103 receiving yards. Defensively, Ji’Ayir Brown has a team-high 17 total tackles (six of them solo).

Arizona Cardinals Preview

The Arizona Cardinals have a 1-1 record this season and are coming off a 7-31 home loss against the Seattle Seahawks. They will face the Giants, the Lions and the Rams next. Offensively, the Cardinals average 16.5 points per game, ranking 24th in the NFL, while defensively, they allow 22.5 points per game, which is 14th. Arizona averages 272 total yards per game (179 passing and 93 rushing), while allowing 324.5 total yards per game (105.5 rushing and 219 passing).

Jacoby Brissett leads the Cardinals with 358 passing yards with 67.7% completed passes and two touchdowns. Jeremiyah Love leads the team in rushing yards with 70, while Trey McBride caught 17 passes for a team-high 136 receiving yards. Defensively, Budda Baker and Jack Gibbens have a team-high 16 total tackles each (11 and six of them solo respectively), while Budda Baker leads the team in sacks, with 1.5.

Arizona Cardinals @ San Francisco 49ers Betting Trends: Week 3

Why the San Francisco 49ers will win

• The Cardinals have lost each of their last 14 games against opponents on a winning streak.
• The 49ers have won each of their last six Sunday games.
• The Cardinals have failed to cover the spread in each of their last six games against NFC West opponents.
• The 49ers have covered the spread in six of their last seven games as favorites without Brayden Willis.
• The 49ers have won the first half in each of their last eight games as favorites.
• The 49ers have won the first quarter in seven of their last eight games in September.
• The 49ers have scored the first touchdown in each of their last four Week 3 games.

Why the Arizona Cardinals will win

• The Cardinals have won each of their last six games against the 49ers following a home loss.
• The 49ers have lost four of their last five games as home favorites against NFC West opponents.
• The Cardinals have covered the spread in each of their last 10 road games in September.
• The 49ers have failed to cover the spread in each of their last eight home games against NFC West opponents.
• The Cardinals have won the first half in four of their last five road games in September.

Total Points Facts

• Each of the Cardinals’ last nine September games as underdogs against NFC West opponents have gone UNDER the total points line.
• Each of the 49ers’ last five games without George Kittle have gone OVER the total points line.
• Five of the last six games between teams from the same division have gone UNDER the total points line.

San Francisco 49ers Player Prop Facts

• Deebo Samuel has scored the last touchdown in each of his last four September appearances against NFC opponents.
• George Kittle has scored a touchdown in each of his last four September appearances with the 49ers as favorites.
• Brock Purdy has recorded 277+ passing yards in each of his last six September appearances with the 49ers as favorites.
• George Kittle has recorded 57+ receiving yards in each of his last 10 appearances with the 49ers as favorites following a win.
• Brock Purdy has recorded 22+ completions in each of his last five September appearances against NFC opponents.
• Brock Purdy has recorded 21+ rushing yards in each of the 49ers’ last six games.
• Deebo Samuel has recorded 44+ rushing and receiving yards in each of his last 12 September appearances against NFC opponents.
• Heading into Week 3, Brock Purdy has the highest completion percentage in a single game (min. 10 ATT) this season (90.9% vs Dolphins, Week 2).

Arizona Cardinals Player Prop Facts

• Trey McBride has scored the last touchdown in three of the Cardinals’ last four games in California.
• Trey McBride has scored at least one touchdown in each of the Cardinals’ last six day games against teams on a winning streak.
• Marvin Harrison Jr. has recorded 33+ receiving yards in each of his last nine road appearances against NFC opponents.
• James Conner has recorded 68+ rushing yards in seven of his last eight appearances following a loss.
• James Conner has recorded 77+ rushing and receiving yards in each of his last 13 appearances following a home loss.
• Heading into Week 3, Chad Ryland has recorded the equal-most made field goals in a single game this season (4 vs Chargers, Week 1).

Matchup/League Facts

• 49ers – seven different players have recorded at least one touchdown this season – most in the NFL, heading into Week 3.
• Heading into Week 3, the 49ers rank 1st in the NFL in red zone percentage (87.5%) this season.
• Heading into Week 3, the Cardinals rank T1st in the NFL in 4th down percentage (100.0%) this season.
• Heading into Week 3, the Cardinals rank T1st in the NFL in Q2 win percentage (100.0) this season.

Cardinals vs 49ers Prediction

In this Cardinals vs 49ers Prediction, the 49ers are coming as -8.5 home favorites. The 49ers have been undefeated this season, having covered the spread in both games and have the 4^th-best offense in the NFL and a +21 point differential. The Cardinals just lost by 24 points at home by the Seahawks and now have to travel to San Francisco, where they have won only once in their last four visits. Their offensive line has been shaky at best and I don’t trust them to keep this close. Take the 49ers and lay the -8.5 points at home.