College Football

Missouri vs Ole Miss Prediction Football Picks Today 10/17/26

Missouri Tigers (5-1) vs. Ole Miss Rebels (4-1)
October 17, 2026 3:30 pm EDT
The Line: Ole Miss Rebels -225 / Missouri Tigers 185; Over/Under: 59
(Get latest betting odds)

In this article, we will formulate a Missouri vs Ole Miss Prediction for this College Football Week 7 matchup on Saturday, October 17th. Let’s take a look at the prediction for this College Football matchup.

Ole Miss Rebels Preview

Ole Miss has a 4-1 record and a 2-1 record in the SEC. They are coming off a 52-17 road win against Vanderbilt and will face Texas and Auburn next.

Offensively, Ole Miss averages 38.8 points per game, ranking 22nd in the nation, while defensively, they allow 28 points per game, which is 109th. Ole Miss averages 433.8 total yards per game (300.6 passing and 133.2 rushing), while allowing 392.4 total yards per game (176.4 rushing and 216 passing).

Trinidad Chambliss leads Ole Miss with 1,435 passing yards with 70.1% completed passes and 11 touchdowns. Kewan Lacy leads the team in rushing yards with 230, while Deuce Alexander has a team-high 503 receiving yards and 32 receptions. Defensively, Luke Ferrelli has a team-high 34 total tackles (18 of them solo), while Blake Purchase leads the team with 3.5 sacks.

Missouri Tigers Preview

Missouri has a 5-1 record and a 2-1 record in the SEC. They are coming off a 27-6 home win against Texas A&M and will face Arkansas and Texas next.

Offensively, Missouri averages 35.8 points per game, ranking 33rd in the nation, while defensively, they allow 17.7 points per game, which is 29th. Missouri averages 438.2 total yards per game (256.5 passing and 181.7 rushing), while allowing 302.5 total yards per game (78.3 rushing and 224.2 passing).

Austin Simmons leads Missouri with 1,434 passing yards with 64.8% completed passes and 14 touchdowns. Jamal Roberts leads the team in rushing yards with 828, while Cayden Lee has a team-high 616 receiving yards and 42 receptions. Defensively, Nicholas Rodriguez has a team-high 63 total tackles (23 of them solo), while Daeden Hopkins leads the team with 7 sacks.

Missouri Tigers @ Ole Miss Rebels Betting Trends: Week 7

 

Why the Ole Miss Rebels will win

  • Ole Miss has won each of its last 15 games in Mississippi.
  • Missouri has lost each of its last six road games against AP-ranked teams.
  • Ole Miss has covered the spread in each of its last six games against AP-ranked teams at Vaught-Hemingway Stadium.
  • Missouri has failed to cover the spread in seven of its last eight October games as an AP-ranked team against an AP-ranked team.
  • Ole Miss has won the first half in each of its last 15 games as an AP-ranked team against an AP-ranked team at Vaught-Hemingway Stadium.
  • Ole Miss has won the first quarter in each of its last seven games in Mississippi.

Why the Missouri Tigers will win

  • Missouri has won five of its last six games.
  • Ole Miss has lost five of its last six October games as a top-10 AP-ranked team against an AP-ranked team.
  • Ole Miss has failed to cover the spread in eight of its last nine October games as a top-15 AP-ranked team against an AP-ranked team.
  • The underdog has covered the spread in four of Ole Miss’ last five games at Vaught-Hemingway Stadium.
  • Missouri has won the first half in three of its last four games.

Total Points Facts

  • Nine of Ole Miss’ last 10 games in Mississippi have gone UNDER the total points line.
  • Each of Missouri’s last five road games against conference opponents have gone UNDER the total points line.

Ole Miss Rebels Player Prop Facts

  • Trinidad Chambliss has recorded a 130.0+ passer rating in 11 consecutive games – longest streak in the FBS.

Missouri Tigers Player Prop Facts

  • Heading into Week 7, Jamal Roberts ranks 2nd amongst FBS players for rushing yards (828) this season.

Matchup/League Facts

  • Ole Miss ranks T1st among FBS teams for red zone percentage this season (100.0).
  • Ole Miss has had a lower time of possession than its opponents in each of its last eight games – longest active streak in the FBS.
  • Missouri has recorded the equal-most home wins by a margin of 10+ points of any FBS team this season (4).
  • Missouri ranks 3rd among FBS teams for Q2 points per game this season (16.8).

Missouri vs Ole Miss Prediction

In this Missouri vs Ole Miss prediction, Ole Miss is coming as -5.5 home favorites. Both teams have been excellent this season with just one defeat so far and both have been scorching-hot offensively, scoring 74.6 points per game combined. Defensively, Ole Miss ranks outside the top-100 of the country while Missouri has been weaker on the road, allowing 26 points per game, so I expect a high-scoring affair. Two of their last three meetings have also gone over the total, so take the over 59 in this one.

Nikos Lagouretos's Free Pick: Over 59

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