College Football

Notre Dame vs Louisville Prediction 9-28-24 College Football Picks

Louisville Cardinals (3-0) vs. Notre Dame Fighting Irish (3-1)
September 28, 2024 3:30 pm EDT
The Line: Notre Dame Fighting Irish -6.5 / Louisville Cardinals +6.5; Over/Under: +48.5
(Get latest betting odds)

In this article we will formulate a Notre Dame vs Louisville prediction for this College Football game on Saturday, September 28th at Notre Dame Stadium in South Bend, Indiana. Let’s take a look at the prediction for this week five matchup. 

Notre Dame Fighting Irish Betting Preview

The Notre Dame Fighting Irish are 3-1 this season after they defeated Miami (OH) by a score of 28-3 last week. Notre Dame trailed 3-0 early in the second quarter, but they scored the last 28 points for the easy win. The Fighting Irish out gained Miami by a total of 428-229, tied the turnover battle at two, and went 5-11 on third down in the game. Riley Leonard threw for 154 yards and one touchdown, while also rushing for 143 yards and two scores. 

Notre Dame also defeated Texas A&M and Purdue earlier in the season, but they did lose to Northern Illinois by a score of 16-14 in their second game. The ND offense has scored 32.8 points per game with 173.8 passing yards and 238.3 rushing yards per game, while the defense has allowed 9.8 points against per game this season. The Fighting Irish have gone 37.8% on third down and 2-4 on fourth down so far this season. Riley Leonard has completed 63.1% of his passes for 587 yards, one touchdown, and two interceptions, while Beaux Collins has caught 16 passes for 176 yards and one score. 

Louisville Cardinals Betting Preview

The Louisville Cardinals are 3-0 (1-0) this year after they defeated Georgia Tech by a score of 31-19 in their last game. Louisville was tied at 17 in the third quarter, but they scored 14 of the last 16 points in the game for the win. The Cardinals were out gained by a total of 410-326, won the turnover battle 1-0, and went 2-9 on third down in the game. Tyler Shough threw for 269 yards and two touchdowns, while Ja’Corey Brooks caught four passes for 125 yards and one score. 

Louisville defeated Austin Peay by a score of 62-0 and Jacksonville State by a score of 49-14 in their first two games. The Louisville offense has scored 45.3 points per game with 308 passing yards and 194.3 rushing yards per game, while the defense has allowed 11.0 points against per game this season. The Cardinals have gone 46.9% on third down and 2-2 on fourth down through three games. Tyler Shough has completed 68.4% of his passes for 850 yards and eight touchdowns, while Isaac Brown has rushed for 173 yards and one score. 

Notre Dame vs Louisville Prediction 

Notre Dame dropped their second game of the season to Northern Illinois at home, but they have bounced back with two blowout wins over Purdue and Miami (OH). The Fighting Irish will have the home field advantage in this game, but they will have to deal with a high powered Louisville offense here. The Cardinals were out gained by Georgia Tech last week, but they were able to still pickup the 12 point win. We are going to learn a lot about Louisville in this game, but their defensive effort last week is a concern. I know Notre Dame’s defense is one of the top units in the country and that will be the difference. Take the Fighting Irish. 

David Racey's Free Pick: Notre Dame -6.5

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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