Angels vs Cubs Prediction 8/22/25 MLB Picks Today

The Chicago Cubs and Los Angeles Angels meet Friday in MLB action at Angel Stadium. Here’s a Angels vs Cubs Prediction. This article will include a Angels vs Cubs Pick.

Chicago Cubs Betting Preview

The Chicago Cubs are 73-55 on the year and play the Giants, Rockies, and Braves next. The Chicago Cubs are batting .249 on the season, have a .319 OBP, and a .427 slugging percentage. The Chicago Cubs pitching staff has a 3.81 ERA and a 1.21 WHIP. Nico Hoerner leads the Chicago Cubs with 134 hits and 49 RBI, while Pete Crow-Armstrong and Dansby Swanson have combined for 240 hits and 137 RBI.

The Chicago Cubs didn’t announce a starting pitcher at the time this article was published.

Los Angeles Angels Betting Preview

The Los Angeles Angels are 61-66 on the year and play the Rangers, Astros, and Royals next. The Los Angeles Angels are batting .233 on the season, have a .306 OBP, and a .407 slugging percentage. The Los Angeles Angels pitching staff has a 4.67 ERA and a 1.43 WHIP. Nolan Schanuel leads the Los Angeles Angels with 123 hits and 49 RBI while Zach Neto and Taylor Ward have combined for 226 hits and 147 RBI.

Tyler Anderson gets the ball for the Los Angeles Angels, and he is 2-8 with a 4.77 ERA and 98 strikeouts this season. Anderson is 6-3 with a 3.69 ERA and 71 strikeouts in his career against the Chicago Cubs.

Why the Los Angeles Angels will win

• The Cubs have lost each of their last six road games against American League opponents following a home loss.
• The home team has won six of the last seven games between the Cubs and Angels.
• The Angels have covered the run line each of their last eight Friday games against teams that held a winning record.
• The Cubs have failed to cover the run line in each of their last six Friday road games against American League opponents.
• The Cubs have trailed after 3 innings in 11 of their last 14 road night games.
• The Cubs have trailed after 5 innings in each of their last seven Friday night games.

Why the Chicago Cubs will win

• The Cubs have won seven of their last eight road games against AL West opponents that held a losing record.
• The Angels have lost each of their last four home games against NL Central opponents following a win.
• The Angels have failed to cover the run line in each of their last eight home games against NL Central opponents.
• The Cubs have covered the run line in 17 of their last 19 road games against AL West opponents that held a losing record.
• The Cubs have won the first inning in four of their last five night games against AL West opponents that held a losing record.
• The Angels have trailed after 3 innings in seven of their last eight home games against NL Central opponents.
• The Cubs have led after 5 innings in each of their last four road games against AL West opponents that held a losing record.

Los Angeles Angels Player Prop Facts

• Tyler Anderson has recorded five or more strikeouts in nine of his 11 previous appearances against the Cubs.
• Nolan Schanuel has recorded two or more hits in each of his last three home appearances after not playing the previous day.
• Jo Adell has hit a home run in four of the Angels’ last five Friday games against opponents that held a winning record.
• Tyler Anderson has recorded a win in three of his last four appearances against the Cubs.

Chicago Cubs Player Prop Facts

• Justin Turner has recorded at least one hit in each of his last 10 road appearances against AL West opponents.
• Kyle Tucker has hit a home run in four of his last five appearances in night games against AL West teams that held a losing record.

Angels vs Cubs Prediction

We don’t know who the Cubs are going to throw out there on the mound, but it probably doesn’t matter. The Cubs are simply the better team, and Anderson has been hit hard this month. In his last 14 innings, Anderson has allowed 13 hits and 12 runs. The Angels have lost each of the last five games Anderson has pitched. The Angels are 3-9 in their last 12 games when Anderson pitches. I’ll roll with the Cubs, despite not knowing what the pitching matchup is going to be.