Astros vs Athletics Prediction 9/23/25 MLB Picks Today

In this article, we will formulate an Astros vs Athletics Prediction for this MLB game on Tuesday, September 23^rd at the Sutter Health Park in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Athletics Preview

The Athletics have a 73-83 record this season and are sitting on the last place of the AL West. The Athletics have a 33-42 home record and are 76-73 in over/under. They are coming off a 0-11 road defeat by the Pirates, and have back-to-back losses. Under is 9-4 in their last 13 games and are playing the Royals next.

The Athletics have a .253 batting average this season, .318 OBP and .432 Slugging percentage. Athletics’ pitching staff has a 4.72 ERA and 1.36 WHIP. Brent Rooker leads the Athletics with 162 hits, while Jacob Wilson is the team’s best hitter with a .315 batting average. Tyler Soderstrom adds a team-high 90 RBI, while Nick Kurtz adds a team-high 33 home runs.

Jeffrey Springs (R) is the projected starter for the Athletics, and he has a 10-11 record, 4.17 ERA, and 1.22 WHIP.

Houston Astros Preview

The Houston Astros have an 84-72 record this season and are sitting on the second place of the AL West. The Astros have a 38-37 road record and 72-78 in over/under. They are coming off a 3-7 home defeat by the Mariners, and have three consecutive losses. They are playing the Angels next.

The Astros have a .251 batting average this season, .316 OBP and .398 slugging percentage. Houston’s pitching staff has a 3.87 ERA and 1.22 WHIP. Jose Altuve leads the Astros with 152 hits, adding a team-high 26 home runs. Jeremy Pena is the team’s best hitter with a .304 batting average, while Christian Walker leads the team in RBI with 82.

Cristian Javier (R) is the projected starting pitcher for the Astros, and he has a 2-3 record, 4.45 ERA and 1.24 WHIP.

Houston Astros @ Athletics Betting Trends: September 23, 2025

• Probable Starting Pitcher: Jeffrey Springs      Record this season: 10-11      ERA: 4.17
• Home Record: 5-5
• Last 5 against Astros: 2-0

Why the Athletics will win

• The Astros have lost each of their last six night games against AL West opponents following a home loss.
• The Athletics have won each of their last five games against the Astros.
• The Athletics have covered the run line each of their last six games against teams that held a winning record.
• The Astros have failed to cover the run line in nine of their last 10 night games against AL West opponents that held a losing record.
• The Athletics have led after 3 innings in each of their last five games against the Astros.
• The Athletics have won the first inning in each of their last three games against the Astros.
• The Athletics have led after 5 innings in each of their last five games against the Astros.

• Probable Starting Pitcher: Cristian Javier      Record this season: 2-3      ERA: 4.45
• Road Record: 0-1
• Last 5 against Athletics: 3-2

Why the Houston Astros will win

• The road team has won each of the last four games between the Astros and Athletics.
• The Athletics have lost each of their last four home games against AL West opponents.
• The Astros have covered the run line in each of their last six road games following a loss.
• The Athletics have failed to cover the run line in each of their last four home games against AL West opponents.
• The Astros have led after 3 innings in eight of their last nine road night games.
• The Athletics have lost the first inning in three of their last four games against AL West opponents.
• The Astros have led after 5 innings in each of their last five road night games.

Total Runs Facts

• Each of the Astros’ last four road games against American League opponents have gone UNDER the total runs line.
• Six of the Athletics’ last seven games against American League opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Astros’ last eight road games against AL West opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Athletics’ last 10 games against American League opponents.

Athletics Player Prop Facts

• Brent Rooker has recorded a Double in three of the Athletics’ last four home games against AL West opponents.
• Shea Langeliers has hit a home run in each of the Athletics’ last three games against the Astros.
• Lawrence Butler has recorded at least one hit in each of his last eight home appearances against opponents that held a winning record.
• Jacob Wilson ranks 2nd amongst qualified players for Batting Average (.315) this season.

Houston Astros Player Prop Facts

• Cristian Javier has recorded five or more strikeouts in eight of his last nine appearances in night games against AL West teams that held a losing record.
• Christian Walker has recorded at least one hit in each of the Astros’ last 16 road games against opponents that held a losing record.
• Victor Caratini has hit a home run in three of his last four road appearances against the Athletics.
• Yordan Alvarez has recorded a Double in each of his last three road appearances against the Athletics.
• Cristian Javier has recorded a win in three of his last four appearances against the Athletics.
• Jeremy Pena ranks 6th amongst qualified players for Batting Average (.304) this season.

Matchup/League Facts

• The Athletics rank 29th in the league for home runs allowed this season (217).
• The Athletics rank 3rd in the league for doubles this season (281).
• The Astros rank 1st in the league for strikeouts this season (1454).
• The Astros rank 27th in the league for steals this season (78).

Astros vs Athletics Prediction

The Athletics have won their last 6 head-to-head meetings against the Astros, but they are 2-2 in their last 4 home meetings against the Astros. Under is 3-1 in their last 4 meetings.

In this Astros vs Athletics Prediction, both teams are coming at a pickem price. The books have adjusted to the Astros’ struggles, and even though they are the better team, they are not favorites in this spot. The A’s have not been better though, as they are coming off back-to-back games where they scored zero runs. Javier has been terrible on the road for the Astros this season, with a 7.88 road ERA, so the value here lies with the home team. As much as I don’t like it, I will lean towards the Athletics to win this one at home.