Boston Red Sox vs San Diego Padres Prediction 05-20-2023 MLB Picks

Chris RuffoloMay 20, 2023
Boston Red Sox vs San Diego Padres Prediction 05-20-2023 MLB Picks player photo
Credit: USA Today Sports

The Boston Red Sox and the San Diego Padres meet in MLB action from Petco Park on Saturday. Let’s dive into the odds, starting pitching matchup, history and make a prediction for this game.


San Diego is a -125 home favorite while Boston is a +105 road underdog. The total for this game is set at 8 runs.

Starting Pitching Matchup

Chris Sale will get the start for the Red Sox and is 3-2 with a 5.40 ERA and 54 strikeouts this season. Joe Musgrove will start for the Padres and is 1-1 with a 6.63 ERA and 19 strikeouts this season.

Matchup History

Boston’s 6-1 win over San Diego on Friday made it 8 wins in the last 10 head-to-head meetings between these two teams.


Boston is 51-18 in their last 69 interleague road games and 5-2 in their last 7 Saturday games while the over is 4-1 in their last 5 games against the NL West. San Diego is 1-7 in their last 8 games overall and 1-4 in their last 5 interleague games while the under is 8-0 in their last 8 interleague games against a team with a winning record.


I’m backing the Red Sox here. Again, I feel that the Padres are overvalued, even laying a reasonable number in this game. The Padres’ lineup takes a huge hit without Manny Machado, and while I like Joe Musgrove, I don’t know if I can back him here. The Red Sox have been hitting righties fairly well in the month of May and I think they get another one here. Give me Boston and the plus money.

Chris Ruffolo's Free Pick:Boston +105
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Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg