Brewers vs Cardinals Prediction 5/6/26 MLB Picks Today

In this article, we will formulate a Brewers vs Cardinals Prediction for this MLB matchup on Wednesday, May 6^th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

St. Louis Cardinals Preview

The St. Louis Cardinals have a 21-14 record this season and are sitting in the second place of the NL Central. They have a 10-9 home record and are coming off a 6-3 home win against the Brewers. Their previous three games were a 1-4 loss, and a 3-2 win and a 7-2 win at home against the Dodgers.

The Cardinals have a .243 batting average this season, .327 OBP and .404 Slugging percentage. St. Louis’ pitching staff has a 4.50 ERA and 1.43 WHIP. Jordan Walker is the team’s best hitter with a .308 batting average, also adding a team‑high 10 home runs. Alec Burleson leads the team in RBI with 28.

Andre Pallante (R) is the projected starting pitcher for the Cardinals, and he has a 3-2 record, 3.73 ERA and 1.31 WHIP.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 18-16 record this season and are sitting in the fifth place of the NL Central. They have a 8-8 away record and are coming off a 3-6 loss on the road against the Cardinals. Their previous three games were a 2-3 loss, and a 4-1 win and a 6-1 win on the road against the Nationals.

The Brewers have a .241 batting average this season, .336 OBP and .358 Slugging percentage. Milwaukee’s pitching staff has a 3.64 ERA and 1.27 WHIP. Brice Turang is the team’s best hitter with a .304 batting average. William Contreras leads the team in RBI with 23, and Gary Sanchez adds a team‑high 5 home runs.

Brandon Sproat (R) is the projected starting pitcher for the Brewers, and he has a 0-2 record, 6.75 ERA and 1.61 WHIP.

Milwaukee Brewers @ St. Louis Cardinals Betting Trends: May 6, 2026

• Probable Starting Pitcher: Andre Pallante      Record this season: 3-2      ERA: 3.73
• Home Record: 1-2
• Last 5 against Brewers: 0-2

Why the St. Louis Cardinals will win

• The Cardinals have won seven of their last eight games.
• The Brewers have lost seven of their last eight road games against National League opponents that held a winning record.
• The Cardinals have covered the run line in each of their last six games against the Brewers.
• The Brewers have failed to cover the run line in seven of their last eight road games against National League opponents following a loss.
• The Cardinals have led after 5 innings in each of their last six games against the Brewers.
• The Cardinals have led after 3 innings in each of their last four games against NL Central opponents.
• The Brewers have lost the first inning in four of their last five road games against National League opponents that held a winning record.

• Probable Starting Pitcher: Brandon Sproat      Record this season: 0-2      ERA: 6.75
• Road Record: 0-1
• Last 5 against Cardinals: –

Why the Milwaukee Brewers will win

• The Brewers have won each of their last eight day games against NL Central opponents following a loss.
• The Cardinals have lost each of their last five home games against NL Central opponents following a win.
• The Brewers have covered the run line in seven of their last eight day games against teams that held a winning record.
• The Cardinals have failed to cover the run line in six of their last seven day games against National League opponents following a home win.
• The Brewers have led after 3 innings in three of their last four games against opponents that held a winning record.
• The Brewers have led after 5 innings in four of their last five day games against NL Central opponents that held a winning record.

Total Runs Facts

• Five of the Cardinals’ last six day games against National League opponents have gone UNDER the total runs line.
• Three of the Brewers’ last four games have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Brewers’ last four games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Cardinals’ last six home games against National League opponents.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has recorded at least one hit in each of his 10 previous appearances against the Brewers after not playing the previous day.
• Lars Nootbaar has hit a home run in three of his last eight home appearances after not playing the previous day.
• Jordan Walker ranks 7th amongst qualified players for Slugging Percentage (.585) this season.

Milwaukee Brewers Player Prop Facts

• Sal Frelick has recorded at least one hit in each of his last 12 road appearances against NL Central opponents.
• Gary Sanchez has hit a home run in three of his last four road appearances against NL Central opponents that held a winning record.
• Brice Turang ranks 3rd amongst qualified players for On Base Percentage (.434) this season.

Matchup/League Facts

• The Cardinals rank 30th in the league for strikeouts this season (243).
• The Cardinals rank T27th in the league for triples this season (1).
• The Brewers rank T1st in the league for home runs allowed this season (28).
• The Brewers rank 29th in the league for home runs this season (23).

Brewers vs Cardinals Prediction

The Cardinals are 4-1 in their last 5 meetings against the Brewers and are 3-1 in their last 4 meetings in Saint Louis.

In this Brewers vs Cardinals Prediction, both teams are coming at a pickem price. The Cardinals keep rolling with a 6-3 win yesterday and are now 7-1 in their last 8 games and have the pitching advantage today as Andre Pallante goes up against Brandon Sproat. Pallante has one earned run in two of his last three starts, while Sproat has given up 14 runs in three of his four starts this season. The Cardinals are better against right-handed pitching and I expect them to keep rolling today, so take them on the moneyline.