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Brewers vs Padres Prediction 5/13/26 MLB Picks Today

San Diego Padres (24-17) vs. Milwaukee Brewers (23-16)
May 13, 2026 7:40 pm EDT
The Line: Milwaukee Brewers -156 / San Diego Padres 129; Over/Under: 7
(Get latest betting odds)

The San Diego Padres and Milwaukee Brewers meet Wednesday in MLB action at American Family Field. Here’s a Brewers vs. Padres Prediction. This article will include a Brewers vs. Padres Pick.

San Diego Padres Betting Preview

The San Diego Padres are 24-17 on the year and play the Dodgers and Mariners next. The San Diego Padres are batting. 223 on the season, have a .297 OBP, and have a .370 slugging percentage. The San Diego Padres pitching staff has a 4.13 ERA and a 1.24 WHIP. Xander Bogaerts leads the San Diego Padres with 39 hits and 23 RBI, while Jackson Merrill and Fernando Tatis Jr. have combined for 70 hits and 33 RBI.

Michael King gets the ball for the San Diego Padres, and he is 3-2 with a 2.76 ERA and 45 strikeouts this season. King is 0-2 with a 3.38 ERA and 27 strikeouts in his career against the Milwaukee Brewers.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 23-16 on the year and play the Cubs and Twins next. The Milwaukee Brewers are batting. 243 on the season, have a .334 OBP, and have a .358 slugging percentage. The Milwaukee Brewers’ pitching staff has a 3.45 ERA and a 1.24 WHIP. William Contreras leads the Milwaukee Brewers with 43 hits and 26 RBI, while Brice Turang and Jake Bauers have combined for 74 hits and 46 RBI.

Jacob Misiorowski gets the ball for the Milwaukee Brewers, and he is 3-2 with a 2.45 ERA and 70 strikeouts this season. This will be Misiorowski’s first career game against the San Diego Padres.

Why the Milwaukee Brewers will win

  • The Brewers have won seven of their last eight home games.
  • The Padres have lost each of their last four night games against teams that held a winning record.
  • The Brewers have covered the run line in eight of their last nine games against National League opponents following a home win.
  • The Padres have failed to cover the run line in each of their last four night games against teams that held a winning record.
  • The Brewers have led after 3 innings in seven of their last eight games as home favorites against NL West opponents.
  • The Brewers have led after 5 innings in five of their last six games as home favorites.

Why the San Diego Padres will win

  • The Padres have won each of their last seven road games following a loss.
  • The Brewers have lost each of their last four Wednesday night games as favorites against National League opponents.
  • The Padres have covered the run line in each of their last seven road games following a loss.
  • The Brewers have failed to cover the run line in 14 of their last 17 home games against National League opponents after playing the previous day.
  • The Padres have led after 5 innings in four of their last five night games against the Brewers at American Family Field.

Total Runs Facts

  • Eight of the Padres’ last nine games after playing the previous day have gone UNDER the total runs line.
  • Five of the Brewers’ last six games after playing the previous day have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in 12 of the Padres’ last 13 games as underdogs.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last five games between the Padres and Brewers at American Family Field.

Milwaukee Brewers Player Prop Facts

  • Brice Turang has recorded at least one hit in each of his last 13 appearances with the Brewers as home favorites against NL West opponents.
  • Andrew Vaughn has hit a home run in each of his last two appearances with the Brewers as home favorites against NL opponents.
  • Jacob Misiorowski ranks 1st in the league for total Strikeouts (70) this season.

San Diego Padres Player Prop Facts

  • Xander Bogaerts has hit a home run in three of the Padres’ last four games as underdogs.
  • Manny Machado has recorded at least one hit in each of the Padres’ last 10 road games against the Brewers.
  • Fernando Tatis Jr. ranks T9th in the league in Steals (10) this season.

Matchup/League Facts

  • The Brewers rank 30th in the league for home runs this season (27).
  • The Brewers rank 1st in the league for home runs allowed this season (31).
  • The Padres rank 30th in the league for hits this season (300).
  • The Padres rank 29th in the league for batting average this season (.223).

Brewers vs Padres Prediction

Hell of a pitching matchup and you can talk yourself into the Padres and the plus money with King on the bump. However, the Brewers are playing better baseball this week and Misiorowski is dealing with a 2.45 ERA, 0.95 WHIP, and he leads baseball in strikeouts. Through 11.1 innings this month, Misiorowski has allowed just two hits and zero runs while striking out 19. The young pitcher looks like a superstar through just 22 career starts. It also doesn’t help that the Padres have never faced him, so a swing-and-miss pitcher gets even tougher. Give me the Brewers and the reasonable price.

Randy Chambers's Free Pick: Milwaukee Brewers -156

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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