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Brewers vs Padres Prediction 6/7/25 MLB Picks Today

San Diego Padres (36-26) vs. Milwaukee Brewers (34-30)
June 7, 2025 7:35 pm EDT
The Line: Milwaukee Brewers -115 / San Diego Padres -105; Over/Under: 8.5
(Get latest betting odds)

In this article, we will formulate a Brewers vs Padres prediction for this MLB game on Saturday, June 7, at American Family Field in Milwaukee, Wisconsin. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Betting Preview

The San Diego Padres (26-26, 16-16 Away) are without a loss in the previous four series. The Padres were on a three-series win streak before splitting a series with the San Francisco Giants. In Friday’s Game 1 against the Brewers, the Padres snatched a 2-0 victory. Randy Vasquez pitched for 4.0 innings in a no-decision, allowing no runs on two hits with two strikeouts and four walks. Wandy Peralta was credited with the win.


This season, the Padres average 4.15 runs per game (19th in the MLB) on a .249/.314/.380 triple-slash. When it comes to pitching, the Padres’ staff has a 3.55 ERA (9th) and 1.20 WHIP (9th). Gavin Sheets leads the Padres with a .259 batting average, 11 home runs, and 38 RBI this season.

Stephen Kolek will take the mound for the Padres on Saturday. The 28-year-old right-hander has a 3-1 record in six starts this year with a 3.47 ERA and 1.24 WHIP in 36.1 innings.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers (34-30, 18-11 Home) are unbeaten in the last five series. The Brewers defeated the Orioles, split with the Pirates, swept the Red Sox and Phillies, and beat the Guardians. However, they failed to score in the opening game of the series against San Diego. Chad Patrick took the loss after allowing one run on four hits with six strikeouts and three walks in 6.0 innings.

This year, the Brewers average 4.57 runs per game (9th in the MLB) on a .239/.315/.368 triple-slash. When it comes to pitching, the Brewers’ staff has a 3.91 ERA (15th) and 1.31 WHIP (19th). Christian Yelich leads the Brewers with a .238 batting average, 13 home runs, and 41 RBI this season.

The projected starting pitcher for the Brewers is Jose Quintana, who is 4-1 in seven starts this season, with a 2.77 ERA and 1.28 WHIP in 39.0 innings.

Why the Brewers will beat the Padres

  • The Brewers have won eight of their last nine games after playing the previous day.
  • The Padres have lost three of their last four road games following a road win.
  • The Brewers have covered the run line in seven of their last eight games as favorites following a home loss.
  • The Padres have failed to cover the run line in four of their last five games following a road win.

Total Runs Facts

  • Each of the Padres’ last four games as underdogs have gone UNDER the total runs line.
  • Ten of the Brewers’ last 12 games as favorites against NL West opponents have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Brewers’ last six games as home favorites.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Padres’ last four games as underdogs.

Matchup/League Facts

  • The Brewers rank 26th in the league for slugging percentage this season (.365).
  • The Brewers rank 25th in the league for triples this season (5).
  • The Padres rank 5th in the league for opponent batting average this season (.225).
  • The Padres rank 25th in the league for home runs this season (55).

Brewers vs Padres Prediction

The Padres won six of the previous ten H2H encounters, including four of the last five. I am backing the Brewers mostly because I believe they have an advantage on the mound. Jose Quintana allowed more than two runs in just one game this season, while Stephen Kolek had three consecutive starts with 3+ runs allowed, although he did respond in the latest against the Giants with a shutout. I like Quintana better, and Milwaukee is in fine form, so I don’t believe the Brewers will drop back-to-back games.


Oliver Zivic

Professional journalist and expert bettor with 20+ years of experience. I cover Football (soccer), NFL, NBA, NHL, MLB, CFB, and CBB.

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