Cardinals vs Brewers Prediction 4/25/25 MLB Picks Today

In this article we will formulate a Cardinals vs Brewers prediction for this MLB game on Friday, April 25th at Busch Stadium in St. Louis, Missouri. Let’s take a look at the prediction for this MLB matchup. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 10-15 this year after they lost two out of three against the Braves by scores of 6-7, 10-4, and 1-4. In their game three loss, the Cardinals led 1-0 in the first inning, but they scored exactly zero runs over the last eight innings for the loss. St. Louis recorded seven hits in the game and they were led by Arenado, who had one RBI in the loss. The Cardinals started Mikolas, who allowed six hits over 6.0 innings, while Romero allowed two earned runs over 0.1 innings for the loss. 

Prior to that series, the Cardinals lost all four against the Mets, but did win two out of three against the Astros before that. St. Louis has lost six of their last seven games and they are currently fourth in the NL Central standings. he St. Louis pitching staff has a 4.37 ERA with a 1.24 WHIP and a .236 opponent batting average, while their offense has scored 120 runs with a .264 batting average and a .335 on base percentage this season. Lars Nootbaar has led St. Louis with four home runs, 14 RBIs, and three stolen bases, while Brendan Donovan has added three home runs and 13 RBIs this year. The projected starting pitcher for St. Louis is Matthew Liberatore, who is 1-2 with a 3.60 ERA and a 1.00 WHIP over 25.0 innings pitched this year. 

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 13-13 this season after they lost three out of four against the Giants by scores of 2-5, 11-3, 2-4, and 5-6. In their loss on Thursday, the Brewers led 5-2 in the fourth inning, but they allowed the last four runs in the game for the heartbreaking loss. Milwaukee recorded nine hits and they committed one error in the game, while they were led by Frelick, Yelich, and Haase, who all had one RBI in the loss. The Brewers started Myers, who allowed four hits and two earned runs over 4.0 innings, while Alexander picked up the loss in the eighth. 

Prior to that series, the Brewers won two out of three against the Athletics and two out of three against the Tigers. Milwaukee has lost four of their last six games and they are currently second in the NL Central standings. The Milwaukee pitching staff has a 4.23 ERA with a 1.33 WHIP and a .236 opponent batting average, while the offense has scored 132 runs with a .245 batting average and a .320 on base percentage this season. Jackson Chourio has led Milwaukee with five home runs and 20 RBIs, while Christian Yelich has also added five home runs and 20 RBIs this year. The projected starting pitcher for Milwaukee is Chad Patrick, who is 1-1 with a 2.11 ERA and a 1.31 WHIP over 21.1 innings pitched this season. 

Why the Cardinals will beat the Brewers

• The Cardinals have won each of their last eight games as favorites against the Brewers following a road loss.
• The Brewers have lost five of their last six road games.
• The Cardinals have covered the run line in nine of their last 10 night games against National League opponents following a road loss.
• The Brewers have failed to cover the run line in seven of their last eight night games against NL Central opponents.
• The Cardinals have led after 5 innings in four of their last five night games at Busch Stadium against National League opponents.

Total Runs Facts

• Eleven of the Cardinals’ last 12 home games against National League opponents have gone UNDER the total runs line.
• Four of the Brewers’ last five night games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cardinals’ last 11 home games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Brewers’ last seven night games against National League opponents.

St. Louis Cardinals Player Prop Facts

• Nolan Arenado has recorded at least one RBI in each of the Cardinals’ last four games as home favorites.
• Masyn Winn has hit a home run in three of the Cardinals’ last six games as favorites against NL Central opponents.
• Nolan Arenado has recorded a Double in four of the Cardinals’ last five games as favorites against the Brewers.
• Willson Contreras has recorded at least one Single in each of his last eight Friday night appearances with the Cardinals as favorites.
• Brendan Donovan has recorded at least one hit in each of the Cardinals’ last 13 games against NL Central opponents.
• Lars Nootbaar has scored at least one run in each of the Cardinals’ last four games as home favorites.

Milwaukee Brewers Player Prop Facts

• William Contreras has hit a home run in each of the Brewers’ last two night games against NL opponents that held a losing record.
• William Contreras has recorded a Double in three of the Brewers’ last four games as underdogs against NL Central opponents.
• William Contreras has recorded a Single in each of his last nine appearances with the Brewers as underdogs.
• William Contreras has recorded at least one hit in each of his last 11 road appearances.
• Jackson Chourio has scored at least one run in seven of the Brewers’ last eight games against opponents that held a losing record.
• William Contreras has recorded at least one RBI in each of the Brewers’ last four games as underdogs against NL Central opponents.

Cardinals vs Brewers Prediction 

St. Louis comes into this series struggling over the last week, but they will be at home, where they are 8-4 on the season. Milwaukee is just 4-9 on the road so far this year and they are coming off of an ugly series in San Francisco. Both of these starting pitchers have been solid to start the 2025 season, but Liberatore has done a very good job of limiting walks + picking up strikeouts. Take the Cardinals to get the win here.