Diamondbacks vs Cubs Prediction 3/28/25 MLB Picks Today

The Chicago Cubs and Arizona Diamondbacks meet on Friday in MLB action at the Chase Field. Here’s a Diamondbacks vs Cubs Prediction. This article will include a Diamondbacks vs Cubs Pick.

Chicago Cubs Betting Preview

The Cubs play the Athletics and Padres after this four-game series. The Chicago Cubs got their first win of the season with a 10-6 win over the Diamondbacks on Thursday. The Cubs exploded offensively for 10 runs on 12 hits, which was greater production than they had in two games against the Dodgers. The Cubs now hope to get to a .500 record with a win on Friday and put those struggles in Tokyo behind them. Ian Happ leads the Cubs with four hits and four RBI, while Jon Berti and Miguel Amaya have combined for six hits and six RBI.

Jameson Taillon gets the ball for the Cubs, and he was 12-8 with a 3.27 ERA and 125 strikeouts last season. Taillon is 1-1 with a 3.50 ERA and 18 strikeouts in his career against the Diamondbacks.

Arizona Diamondbacks Betting Preview

The Diamondbacks will play the Yankees and Nationals after this series. The Arizona Diamondbacks struck first in their season opener, but their pitching got rocked for the remainder of the game, and it resulted in a loss. The Diamondbacks hope to avoid their first 0-2 start since the 2021 season. The good news for the Diamondbacks is that they’re supposed to be one of the best offenses in baseball, and the offense did show up out of the gate. Ketel Marte leads the Diamondbacks with two hits, while Gabriel Moreno and Corbin Carroll have combined for three hits.

Merrill Kelly gets the ball for the Diamondbacks, and he was 5-1 with a 4.03 ERA and 63 strikeouts last season. Kelly is 2-1 with a 3.78 ERA and 30 strikeouts in his career against the Cubs.

Why the Arizona Diamondbacks will win

• The Diamondbacks have won 13 of their last 14 games against NL Central opponents following a home loss.
• The Cubs have lost 15 of their last 17 night games against NL West opponents following a road win.
• The Cubs have failed to cover the run line in each of their last four games as underdogs against National League opponents following a win.
• The favorites have covered the run line in four of the Cubs’ last five games.
• The Diamondbacks have led after 3 innings in 10 of their last 13 games against NL Central opponents that held a losing record.
• The Cubs have trailed after 5 innings in each of their last three games at Chase Field against National League opponents that held a losing record.
• The Diamondbacks have won the first inning in each of their last four games against NL Central opponents.

Why the Chicago Cubs will win

• The underdogs have won eight of the Cubs’ last nine games at Chase Field.
• The Diamondbacks have lost four of their last five games as home favorites against NL Central opponents.
• The underdogs have covered the run line in each of the Cubs’ last 11 games at Chase Field.
• The Diamondbacks have failed to cover the run line in 12 of their last 13 games as home favorites against NL Central opponents.
• The Diamondbacks have trailed after 3 innings in each of their last four night games against opponents that held a losing record.
• The Diamondbacks have trailed after 5 innings in each of their last four night games against National League opponents that held a losing record.
• The Cubs have won the first inning in three of their last four night games against National League opponents that held a losing record.

Diamondbacks vs Cubs Prediction

The Diamondbacks are the better team on paper, but I’m rolling with the Cubs and the plus money. Kelly was hittable last year, and current Cubs are batting .263 against him in 80 at-bats with a .298 on-base percentage. Taillon has been an OK-ish pitcher throughout his career, and he’s holding current Diamondbacks to a .205 batting average and 19 strikeouts in 83 at-bats.

The Cubs also found their offense last night, and with three games now under their belt, they’ve had the benefit of building a rhythm more than any other team besides the Dodgers. I’ll take a shot with the Cubs and the plus money on Friday night.