
Diamondbacks vs Padres Prediction 8-6-25 MLB Picks Today
San Diego Padres (63-51) vs. Arizona Diamondbacks (54-60)
August 6, 2025 9:40 pm EDT
The Line: Arizona Diamondbacks 0.0001 / San Diego Padres 0.0001; Over/Under: 0.0001
(Get latest betting odds)
In this article, we will formulate a Diamondbacks vs Padres prediction for this MLB game on Wednesday, August 6, at Chase Field in Phoenix, Arizona. Let’s take a look at the prediction for this MLB matchup.
San Diego Padres Betting Preview
The San Diego Padres (63-51, 27-32 Away) have swept the New York Mets and defeated the St. Louis Cardinals in two series before this divisional clash with Arizona. San Diego lost Game 1 but bounced back with a 10-5 extra innings victory on Tuesday. Ramon Laureano led the offense with three RBI, while Yu Darvish pitched for 4.0 innings in a no-decision, allowing three runs on four hits with five strikeouts and two walks in 4.0 innings. Robert Suarez was credited with the win.
This year, the Padres average 4.12 runs per game (24th in the MLB) on a .251/.319/.381 triple-slash. When it comes to pitching, the Padres’ staff has a 3.56 ERA (3rd) and 1.21 WHIP (3rd). Manny Machado leads the Padres with a .302 batting average, 20 home runs, and 72 RBI this season.
The projected starting pitcher for the Padres is Nestor Cortes, who is 1-1 in two starts this season, with a 9.00 ERA and 1.75 WHIP in 8.0 innings.
Arizona Diamondbacks Betting Preview
The Arizona Diamondbacks (54-60, 27-29 Home) lost a series against the Pittsburgh Pirates and were swept by the Detroit Tigers, but responded with a win over the Athletics. Arizona also beat San Diego in Game 1 of the current series, but fell to a 10-5 defeat in extra innings last night. Lourdes Gurriel Jr. led the offense with a pair of homers and four RBI, while Ryne Nelson pitched for 5.2 innings in a no-decision, allowing two runs on six hits with eight strikeouts and two walks. Jake Woodford took the loss.
This season, the Diamondbacks average 4.84 runs per game (6th in the MLB) on a .249/.324/.435 triple-slash. When it comes to pitching, the Diamondbacks’ staff has a 4.57 ERA (25th) and 1.33 WHIP (24th). Geraldo Perdomo leads the Diamondbacks with a .278 batting average, 11 home runs, and 75 RBI this season.
Anthony DeSclafani will take the mound for the Diamondbacks on Wednesday. The 35-year-old right-hander has a 1-2 record in two starts this year with a 4.91 ERA and 1.29 WHIP in 25.2 innings.
Why the Padres will beat the Diamondbacks
- The Diamondbacks have lost six of their last seven night games after going to extra innings.
- The Padres have won eight of their last 10 games.
- The Diamondbacks have failed to cover the run line in each of their last six games against National League opponents after going to extra innings.
- The Padres have covered the run line in nine of their last 11 games after going to extra innings.
Total Runs Facts
- Fifteen of the Diamondbacks’ last 16 games following an extra-innings loss have gone OVER the total runs line.
- Eight of the Padres’ last 10 games as favorites against the Diamondbacks have gone OVER the total runs line.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Diamondbacks’ last four home games against National League opponents.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Padres’ last six night games at Chase Field.
Matchup/League Facts
- The Diamondbacks rank T4th in the league for walks this season (399).
- The Diamondbacks rank T5th in the league for doubles this season (198).
- The Padres rank 2nd in the league for ERA this season (3.59).
- The Padres rank 2nd in the league for opponent batting average this season (.228).
Diamondbacks vs Padres Prediction
The Diamondbacks won six of the previous ten H2H encounters, while this season, Arizona leads 5-4. I am going with the Padres in this one, because of Nestor Cortes, who will be back from a lengthy injury and will get his first start for San Diego after joining from the Brewers in a trade. Anthony DeSclafani, on the other hand, is a reliever and I don’t think he will stay on the mound for more than three or four innings. San Diego will have a chance to score a few runs while he’s on. Back the Padres.