Guardians vs Dodgers Prediction 5/28/25 MLB Picks Today

The Los Angeles Dodgers and the Cleveland Guardians meet Wednesday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Guardians vs Dodgers Prediction.

Starting Pitching Matchup

The Los Angeles Dodgers will send out Clayton Kershaw for the start here, and Kershaw is 0-0 with a 7.50 ERA and 3 strikeouts this season. In his career, Kershaw is 1-0 with a 3.79 ERA and 17 strikeouts against the Guardians. Cleveland will send Slade Cecconi for the start here, and Cecconi is 1-1 with a 3.27 ERA and 14 strikeouts this season. This will be Cecconi’s first career start against the Dodgers.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to build on their 9-5 win over the Guardians from Tuesday’s matchup to improve to 34-21 on the year. After this series, the Dodgers will head home for a headliner series against the New York Yankees.

Dodgers Pick Up 5^th Win In Last 7

Shohei Ohtani has 62 hits, including 9 doubles, 19 home runs, 33 RBIs, and 4 triples, while Tommy Edman has 31 hits with 8 home runs and 26 RBIs. Michael Conforto has 25 hits with 9 doubles, while Teoscar Hernandez has 47 hits with 10 home runs, 13 doubles, and 42 RBIs as well this season. Ohtani has a team-high 11 stolen bases, while Max Muncy has 8 doubles but also has 50 strikeouts so far this season. Mookie Betts has also chipped in 8 home runs and 31 RBIs on the year. Freddie Freeman has also logged 57 hits with a team-high 14 doubles, 9 home runs, and 35 RBIs.

Why the Los Angeles Dodgers will win

• The Guardians have lost each of their last eight day games against NL West opponents that held a winning record.
• The Dodgers have won each of their last seven games against AL Central opponents.
• The Guardians have failed to cover the run line in each of their last eight day games against NL West opponents.
• The road team has covered the run line in seven of the Guardians’ last eight games.

Los Angeles Dodgers Player Prop Facts

• Shohei Ohtani has hit at least one home run in each of the Dodgers’ last four games against AL opponents that held a winning record.
• Shohei Ohtani has recorded at least one RBI in seven of the Dodgers’ last eight road games against AL Central opponents.
• Freddie Freeman has recorded at least one Single in each of the Dodgers’ last nine games as road favorites.
• Shohei Ohtani has scored at least one run in each of the Dodgers’ last seven games as road favorites.
• Clayton Kershaw has recorded four or more strikeouts in each of his last 14 appearances against AL opponents that held a winning record.
• Mookie Betts has recorded at least one hit in each of his last 13 road appearances against AL Central opponents.
• Clayton Kershaw has recorded a win in four of his last five appearances with the Dodgers as road favorites against AL Central opponents.
• Shohei Ohtani ranks 1st in the league in Home Runs (20) this season.

Cleveland Guardians Recap

The Cleveland Guardians will be out to bounce back from their loss at the hands of the Dodgers on Tuesday to drop to 29-25 on the year. After this series, the Guardians will take on the Los Angeles Angels at home.

Guardians Lose Third Straight

Steven Kwan leads the Guardians with 65 hits as part of a .314 batting average and 4 home runs, 12 doubles, and 19 RBIs. Kyle Manzardo has 36 hits with 6 doubles, 2 triples, 10 home runs, and a team-high 28 RBIs this year. Gabriel Arias has 9 doubles but also 52 strikeouts, and Manzardo has 52 strikeouts so far this season. Arias has also added 4 home runs and 20 RBIs, and Jose Ramirez has chipped in 9 home runs and 26 RBIs. Carlos Santana has also added 40 hits with 6 home runs and 27 RBIs this season.

Why the Cleveland Guardians will win

• The Dodgers have lost five of their last six games as favorites following a road win.
• The Guardians have won five of their last six day games at Progressive Field following a loss.
• The Dodgers have failed to cover the run line in six of their last seven games following a road win.
• The Guardians have covered the run line in four of their last five day games at Progressive Field following a home loss.

Cleveland Guardians Player Prop Facts

• Carlos Santana has hit a home run in each of his last two appearances in day games.
• Steven Kwan has recorded at least one Double in three of his last four appearances in day games against teams that held a winning record.
• Carlos Santana has recorded at least one RBI in four of his last five appearances in day games.
• Jose Ramirez has scored at least one run in seven of the Guardians’ last eight games.
• Steven Kwan has recorded at least one Single in nine of his last 10 appearances in day games against teams that held a winning record.
• Carlos Santana has recorded at least one hit in each of his last seven appearances.
• Steven Kwan ranks T5th in the league in Hits (66) this season.

Total Runs Facts

• Seven of the Dodgers’ last eight games as favorites against American League opponents have gone OVER the total runs line.
• Four of the Guardians’ last five home games against NL West opponents have gone OVER the total runs line.

Guardians vs Dodgers Prediction

I’m on the Dodgers here. I just think that the Dodgers have Cleveland’s number in this series, and Slade Cecconi isn’t going to convince me otherwise. Cecconi may have had a decent start to this season, but in two career relief appearances, he’s been shelled against the Dodgers, and I think the Dodgers get to him here. Cleveland hasn’t been as sharp against lefties, and I think this could be a good spot for Clayton Kershaw. Give me the Dodgers here.