Guardians vs Twins Prediction 4/29/25 MLB Picks Today

In this article, we will formulate a Guardians vs Twins prediction for this MLB game on Tuesday, April 29th at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 15-13 this season after they lost game one in this series by a score of 11-1 on Monday night. Cleveland allowed the first six runs in the game, and they never had a chance in this one. The Guardians recorded eight hits in the game, and they were led by Noel, who went 1-4 with one RBI in the loss. Cleveland started Williams, who allowed seven hits and four earned runs over 2.0 innings in the loss, while Herrin, Bolton, and Wilson all allowed at least two earned runs in relief. 

Prior to this series, the Guardians lost two out of three against the Red Sox, but did win two out of three against the Yankees before that. Cleveland has lost four of their last five games, and they are currently second in the AL Central standings. The Cleveland pitching staff has a 4.61 ERA with a 1.46 WHIP and a .263 opponent batting average, while the offense has scored 108 runs with a .237 batting average and a .306 on-base percentage this season. Kyle Manzardo has led Cleveland with seven home runs and 18 RBIs, while Steven Kwan has added four home runs and 15 RBIs this year. The projected starting pitcher for Cleveland is Tanner Bibee, who is 2-2 with a 5.19 ERA and a 1.46 WHIP over 26.0 innings pitched this season. 

Minnesota Twins Betting Preview

The Minnesota Twins are 13-16 this year after they won game one in this series on Monday night. Minnesota scored four runs in the first two innings and piled on the runs in the fifth and sixth innings for the blowout win. The Twins recorded 17 hits in the game, and they were led by Jeffers, who went 2-4 with one home run, three RBIs, and one walk in the win. Minnesota started Ober, who allowed eight hits and one earned run over 7.2 innings in the win, while Alcala finished the last 1.1 innings. 

Prior to this series, the Twins won all three against the Angels and two out of three against the White Sox. Minnesota has won six of its last seven games, and they are currently fourth in the AL Central standings. The Minnesota pitching staff has a 3.55 ERA with a 1.21 WHIP and a .238 opponent batting average, while their offense has scored 117 runs with a .234 batting average and a .310 on-base percentage this season. Byron Buxton has led Minnesota with six home runs and 17 RBIs, while Harrison Bader has added three home runs and 13 RBIs this year. The projected starting pitcher for Minnesota is Chris Paddack, who is 0-3 with a 6.45 ERA and a 1.61 WHIP over 22.1 innings pitched this season. 

Why the Guardians will beat the Twins

• The Guardians have won each of their last 12 Tuesday games against teams that held a losing record.
• The Twins have lost eight of their last nine games following a road win.
• The favorites have covered the run line in six of the Twins’ last eight games.
• The Guardians have led after 5 innings in four of their last five night games against AL Central opponents that held a losing record.
• The Guardians have led after 3 innings in four of their last five night games against AL Central opponents that held a losing record.

Why the Twins will beat the Guardians

• The underdogs have won seven of the last eight games between the Twins and Guardians.
• The Guardians have lost three of their last four games as favorites against American League opponents following a home loss.
• The Guardians have failed to cover the run line in each of their last 10 night games against the Twins at Progressive Field following a loss.
• The underdogs have covered the run line in each of the last eight games between the Twins and Guardians.
• The Twins have won the first inning in each of their last four games against American League opponents.
• The Twins have led after 3 innings in seven of their last eight games against American League opponents.
• The Twins have led after 5 innings in each of their last seven night games against AL Central opponents that held a winning record.

Total Runs Facts

• Each of the Guardians’ last four games have gone OVER the total runs line.
• Twelve of the Twins’ last 15 games as underdogs against AL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Guardians’ last seven Tuesday games against AL Central opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Twins’ last four games.

Cleveland Guardians Player Prop Facts

• Carlos Santana has recorded an RBI in four of his last five appearances with the Guardians as home favorites against the Twins.
• Steven Kwan has scored at least one run in four of his last five appearances with the Guardians as favorites against the Twins.
• Carlos Santana has recorded at least one hit in each of his last eight appearances in night games against teams that held a losing record.
• Steven Kwan has recorded at least one Single in each of the Guardians’ last six night games.
• Lane Thomas has hit a home run in each of his last three Tuesday night appearances with the Guardians as favorites.
• Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.

Minnesota Twins Player Prop Facts

• Trevor Larnach has hit a home run in three of the Twins’ last four night games.
• Ty France has scored at least one run in each of the Twins’ last seven road games against AL Central opponents.
• Carlos Correa has recorded at least one Single in each of the Twins’ last four games.
• Chris Paddack has recorded four or more strikeouts in each of his last seven appearances against opponents that held a winning record.
• Jonah Bride has recorded at least one hit in each of his last 13 appearances with his team as a road underdog against AL opponents.
• Jonah Bride has recorded at least one RBI in seven of his last eight road appearances against AL opponents.
• Willi Castro has recorded a Double in each of his last three appearances with the Twins as underdogs against AL Central opponents.

Guardians vs Twins Prediction 

Minnesota was able to start this series with a blowout victory on Monday night, and they have played very well over the last week. The Twins are just 4-10 on the road this year, while the Guardians are 8-5 at home. Cleveland has lost three games in a row, and they have allowed 31 runs in those three games. The Guardians will send Bibee to the mound, who has allowed six earned runs or more in two of his last four starts. The Twins are going with Paddack, who has allowed two earned runs or fewer in three straight. Both of these pitchers have allowed plenty of baserunners this year, and I think we will see plenty of runs, so take the over here.