Houston Astros vs LA Dodgers Prediction 5/6/26 MLB Picks Today

The Los Angeles Dodgers and the Houston Astros meet Wednesday in MLB action from Daikin Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Dodgers vs. Houston Astros prediction.

Starting Pitching Matchup

The Los Angeles Dodgers will send out Tyler Glasnow for the start here and Glasnow is 3-0 with a 2.56 ERA and 47 strikeouts this season. This will be Glasnow’s second career start against Houston. Lance McCullers Jr. will start for Houston here and is 2-2 with a 6.32 ERA and 33 strikeouts this season. In his career, McCullers Jr. is 2-0 with a 1.14 ERA and 26 strikeouts against the Dodgers.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to bounce back from a 2-1 loss at the hands of the Astros on Tuesday to fall to 22-14 this season. After this series, the Dodgers will head home for a series against the Atlanta Braves.

Dodgers Have Two-Game Win Streak Snapped

Andy Pages has 43 hits with 8 doubles, 5 home runs and 27 RBIs while Teoscar Hernandez has 28 hits with 4 doubles, 4 home runs and 17 RBIs. Shohei Ohtani has 30 hits with 6 doubles, 6 home runs and 14 RBIs and Freddie Freeman has 38 hits with 9 doubles, a triple, 3 home runs and 18 RBIs this season. Will Smith has 3 home runs as well this season. Max Muncy’s added 33 hits with 5 doubles, 9 home runs and 13 RBIs and Kyle Tucker has 33 hits with 7 doubles, 4 home runs and 19 RBIs this season.

Houston Astros Recap

The Houston Astros come into this game looking to add on to their win over the Dodgers from Tuesday to improve to 15-22 this season. After this series, the Astros will head on the road for a series against the Cincinnati Reds.

Astros Looking For Another Series Win

Yordan Alvarez has 45 hits with 9 doubles, 12 home runs and 27 RBIs while Christian Walker has 41 hits with 9 doubles, 9 home runs and 27 RBIs on the year. Jose Altuve’s chipped in 32 hits with 9 doubles, 3 home runs and 9 RBIs and Carlos Correa has 34 hits with 8 doubles, 3 home runs and 16 RBIs. Cam Smith also has 28 hits with 6 doubles, 4 home runs and 17 RBIs. Yainer Diaz also has 25 hits with 5 doubles, 2 home runs and 14 RBIs.

Los Angeles Dodgers @ Houston Astros Betting Trends: May 6, 2026

• Probable Starting Pitcher: Lance McCullers Jr.      Record this season: 2-2      ERA: 6.32
• Home Record: 1-2
• Last 5 against Dodgers: 2-0

Why the Houston Astros will win

• The Astros have won seven of their last eight games as underdogs against NL West opponents.
• The Dodgers have lost seven of their last eight games as favorites against AL West opponents following a loss.
• The Dodgers have failed to cover the run line in each of their last eight games against AL West opponents following a loss.
• The Astros have covered the run line in seven of their last eight games as underdogs against the Dodgers.
• The Dodgers have trailed after 3 innings in each of their last four day games against American League opponents.
• The Dodgers have trailed after 5 innings in four of their last five games against opponents that held a losing record.
• The Astros have won the first inning in three of their last four home games.

• Probable Starting Pitcher: Tyler Glasnow      Record this season: 3-0      ERA: 2.56
• Road Record: 3-0
• Last 5 against Astros: 1-3

Why the Los Angeles Dodgers will win

• The Dodgers have won each of their last six day games against AL West opponents following a road loss.
• The Astros have lost six of their last seven games following a win.
• The Astros have failed to cover the run line in each of their last five day games against National League opponents.
• The Dodgers have covered the run line in each of their last four road games against the Astros following a loss.
• The Dodgers have led after 3 innings in nine of their last 11 road day games.
• The Astros have trailed after 5 innings in five of their last six games against National League opponents.

Total Runs Facts

• Eight of the Astros’ last nine games as home underdogs have gone OVER the total runs line.
• Six of the Dodgers’ last seven road games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last eight Wednesday games against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Dodgers’ last six day games.

Houston Astros Player Prop Facts

• Lance McCullers Jr. has recorded a win in three of his last four appearances with the Astros as underdogs against NL opponents.
• Christian Walker has hit at least one home run in eight of his last 10 appearances against the Dodgers.
• Lance McCullers Jr. has recorded eight or more strikeouts in three of his last four appearances with the Astros as home underdogs.
• Isaac Paredes has recorded at least one hit in each of the Astros’ last nine day games.
• Yordan Alvarez ranks T4th in the league in Hits (45) this season.

Los Angeles Dodgers Player Prop Facts

• Kyle Tucker has hit at least one home run in five of his last seven appearances with his team as a road favorite against AL West opponents.
• Tyler Glasnow has recorded nine or more strikeouts in each of his last five appearances against AL opponents that held a losing record.
• Tyler Glasnow has recorded a win in four of his last five appearances against AL opponents that held a losing record.
• Kyle Tucker has recorded at least one hit in each of his last 14 road appearances against AL opponents that held a losing record.

Matchup/League Facts

• The Astros rank 1st in the league for doubles this season (73).
• The Astros rank 30th in the league for ERA this season (5.65).
• The Dodgers rank 1st in the league for opponent batting average this season (.212).
• The Dodgers rank 1st in the league for hits allowed this season (245).

Los Angeles Dodgers vs. Houston Astros Prediction

I’m on the Dodgers here. I just think Lance McCullers Jr. has been batting practice for opposing teams more often than not this season and since coming back from his injury last season and while the Dodgers have been hit or miss over the last couple of weeks, I still think they’re the better team in this matchup and should have no problems getting the job done and backing up Glasnow for the win here so give me the Dodgers in this one.