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LA Dodgers vs Arizona Diamondbacks Prediction 3/27/26 MLB Picks Today

Arizona Diamondbacks (0-1) vs. LA Dodgers (1-0)
March 27, 2026 10:10 pm EDT
The Line: LA Dodgers -252 / Arizona Diamondbacks +203; Over/Under: 8.5
(Get latest betting odds)

The Arizona Diamondbacks and the Los Angeles Dodgers meet Friday in MLB action from Dodger Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Diamondbacks vs. Los Angeles Dodgers prediction.

Starting Pitching Matchup

The Arizona Diamondbacks will send out Ryne Nelson for the start here and Nelson was 7-3 with a 3.39 ERA and 132 strikeouts last season. In his career, Nelson is 1-0 with a 2.74 ERA and 20 strikeouts against the Dodgers. Emmet Sheehan will start this one for Los Angeles and was 6-3 with a 2.82 ERA and 89 strikeouts last season.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to bounce back from an 8-2 loss at the hands of the Dodgers last time out to slip to 0-1. After this series, the Diamondbacks will take on the Detroit Tigers in an interleague series at home.

Diamondbacks Looking To Get Even

Geraldo Perdomo went 2 for 4 with a 2-run home run to make up the scoring for Arizona in the losing effort while Jordan Lawlar added a double. Tim Tawa, Nolan Arenado and Corbin Carroll all chipped in a base hit as well to cap off the offense for Arizona in the loss. Zac Gallen ended up with the loss after allowing 4 earned runs on 5 hits with a pair of strikeouts over four innings of work to slip to 0-1 on the year.

Why the Arizona Diamondbacks will win

  • The Diamondbacks have won each of their last five Friday night games as road underdogs against the Dodgers.
  • The Dodgers have lost three of their last four games as home favorites against the Diamondbacks following a home win.
  • The Diamondbacks have covered the run line in 10 of their last 11 games at UNIQLO Field at Dodger Stadium against teams that held a winning record.
  • The Dodgers have failed to cover the run line in four of their last five games following a win.

Arizona Diamondbacks Player Prop Facts

  • Corbin Carroll has hit a home run in each of the Diamondbacks’ last two games at UNIQLO Field at Dodger Stadium against opponents that held a winning record.
  • Ryne Nelson has recorded four or more strikeouts in each of his last four appearances against NL West opponents.
  • Ildemaro Vargas has recorded at least one hit in each of his last 12 appearances in night games.
  • Geraldo Perdomo ranked 5th amongst qualified players for On Base Percentage (.389) last season.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to add on to their win over the Diamondbacks from Thursday’s opener to improve to 1-0. After this series, the Dodgers will play host to the Cleveland Guardians at home.

Dodgers Looking For Series Win To Start Year

Will Smith and Andy Pages each went 2 for 4 with a home run and three RBIs apiece while Kyle Tucker had a double with an RBI and Mookie Betts added an RBI as well to cap off the Dodgers’ scoring in the win. Miguel Rojas, Max Muncy, Teoscar Hernandez and Shohei Ohtani each added a base knock as well to cap off the Dodgers’ offense in the winning effort. Yoshinobu Yamamoto got the win to improve to 1-0 after allowing 2 runs on five hits over six innings of work with six strikeouts. 

Why the Los Angeles Dodgers will win

  • The Dodgers have won each of their last 12 night games after playing the previous day.
  • The Diamondbacks have lost each of their last six games.
  • The Diamondbacks have failed to cover the run line in each of their last seven games following a loss.
  • The favorites have covered the run line in each of the Diamondbacks’ last five games.

Los Angeles Dodgers Player Prop Facts

  • Andy Pages has hit a home run in each of the Dodgers’ last three games against the Diamondbacks.
  • Kyle Tucker has recorded a Double in four of his last five appearances at UNIQLO Field at Dodger Stadium.
  • Mookie Betts has recorded at least one hit in each of the Dodgers’ last 14 games as favorites against the Diamondbacks.
  • Shohei Ohtani ranked 2nd amongst qualified players for Slugging Percentage (.622) last season.

Total Runs Facts

  • Five of the Dodgers’ last six games against National League opponents have gone UNDER the total runs line.
  • Four of the Diamondbacks’ last five road games have gone OVER the total runs line.

Arizona Diamondbacks vs. Los Angeles Dodgers Prediction

I’m on the Diamondbacks +1.5 here. The Dodgers are the rightful favorites here, and if their offense is going to look like this for a 162-game season, the rest of Major League Baseball could be in for a rough go. However, Ryne Nelson was the brightest upside for the Diamondbacks rotation last year and held his own against the Dodgers. Sheehan was solid in spots, but this is an interesting case study of what he’ll do this early in the year and I think the Diamondbacks can keep this one competitive. Give me the Diamondbacks +1.5.

Chris Ruffolo's Free Pick: Arizona Diamondbacks +1.5

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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