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Milwaukee Brewers vs Chicago Cubs Prediction 7-30-25 Picks

Chicago Cubs (62-45) vs. Milwaukee Brewers (64-43)
July 30, 2025 6:10 pm EDT
The Line: Milwaukee Brewers -123 / Chicago Cubs +101; Over/Under: 7.5
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The Chicago Cubs and the Milwaukee Brewers meet Wednesday in MLB action from American Family Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago Cubs vs. Milwaukee Brewers prediction.

Starting Pitching Matchup

The Chicago Cubs will send out Shota Imanaga for the start here, and Imanaga is 7-4 with a 3.12 ERA and 55 strikeouts this season. In his career, Imanaga is 0-2 with an 8.10 ERA and 5 strikeouts against Milwaukee. Freddy Peralta will get the nod for the Brewers here and is 12-4 with a 2.81 ERA and 131 strikeouts this season. In his last five starts against the Cubs, Peralta is 3-1 with a 2.51 ERA and 37 strikeouts.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to rebound from their loss at the hands of the Brewers to sit at 62-45 on the year, thanks to their 9-3 loss. After this series, the Cubs will head home for a series against the Baltimore Orioles.

Cubs Drop 6 Of Their Last 9

Ian Happ has 85 hits with 16 doubles, 14 home runs, and 49 RBIs. Kyle Tucker has 105 hits, including 20 doubles, 4 triples, 18 home runs, and 58 RBIs, while Seiya Suzuki also has 101 hits with 24 doubles and 26 home runs and 81 RBIs of his own. Pete Crow-Armstrong also has contributed 109 hits, 28 doubles, 4 triples, 27 home runs, and 76 RBIs this season. Dansby Swanson has added 16 home runs and 49 RBIs, while also having 120 strikeouts, and Suzuki has 119 strikeouts so far this season. Crow-Armstrong also has a team-high 29 stolen bases, while Nico Hoerner has 19 stolen bases this season. Tucker’s also added 23 stolen bases while Michael Busch has also chipped in 15 doubles, 3 triples, 20 home runs, and 60 RBIs this season.

Why the Chicago Cubs will win

  • The Cubs have won each of their last 12 day games following a road loss.
  • The Cubs have covered the run line in each of their last 10 Wednesday games as underdogs against NL Central opponents.
  • The Brewers have failed to cover the run line in nine of their last 10 games as home favorites against NL Central opponents following a win.

Chicago Cubs Player Prop Facts

  • Nico Hoerner has hit a home run in each of the Cubs’ last two games as road underdogs against the Brewers.
  • Shota Imanaga has recorded a win in four of his last five appearances with the Cubs as road underdogs.
  • Shota Imanaga has recorded five or more strikeouts in four of his last five appearances against opponents that held a winning record.
  • Nico Hoerner has recorded at least one hit in each of the Cubs’ last 14 road games against NL Central opponents that held a winning record.
  • Ian Happ has recorded a Double in each of the Cubs’ last six games as road underdogs against NL Central opponents.
  • Pete Crow-Armstrong ranks T5th in the league in Steals (29) this season.

Milwaukee Brewers Recap

The Milwaukee Brewers come into this game looking to build on their win over the Cubs on Tuesday to sit at 64-43 on the year. After this series, the Brewers will take to the road for a set against the Washington Nationals.

Brewers Win Three Straight

Brice Turang has 105 hits with 6 home runs, 43 RBIs and 19 stolen bases while Jackson Chourio has 121 hits with a team-high 29 doubles, 18 stolen bases, 17 home runs and 67 RBIs and Sal Frelick has 102 hits as well as 3 triples, 7 home runs, 39 RBIs and 17 stolen bases so far this season. Christian Yelich also has 15 stolen bases with 19 homers and 66 RBIs while also adding 11 doubles. Yelich also has a team-high 115 strikeouts up to this point in the year. William Contreras has 6 homers and 42 RBIs as well this season. Rhys Hoskins has added 65 hits with 12 home runs, 42 RBIs, and 12 doubles.

Why the Milwaukee Brewers will win

  • The Brewers have won each of their last eight games against National League opponents following a home win.
  • The Cubs have lost six of their last seven games at American Family Field against NL Central opponents that held a winning record.
  • The Brewers have covered the run line each of their last 12 games against teams that held a winning record.
  • The Cubs have failed to cover the run line in 13 of their last 14 Wednesday games.

Milwaukee Brewers Player Prop Facts

  • Brice Turang has recorded a Double in four of his last five appearances in day games against teams that held a winning record.
  • Andrew Vaughn has hit a home run in three of his last four home appearances against the Cubs.
  • Freddy Peralta has recorded seven or more strikeouts in each of his last four home appearances against NL opponents.
  • Andrew Vaughn has recorded at least one hit in each of his last 16 home appearances against NL opponents.
  • Freddy Peralta has recorded a win in seven of his last eight appearances.
  • Freddy Peralta ranks T1st in the league for Wins (12) this season.

Total Runs Facts

  • Each of the Cubs’ last five games against NL Central opponents have gone OVER the total runs line.
  • Five of the Brewers’ last six games against NL Central opponents have gone OVER the total runs line.

Chicago Cubs vs. Milwaukee Brewers Prediction

I’m on the Brewers here. I get the case to be made for the Cubs with their best arm in Imanaga going here, but the problem I have is that the Brewers continue to take it to left-handed pitching, and he’s still a solid option, but this is just a bad matchup for Imanaga here. The Brewers also have the edge in the bullpen, and Peralta’s been at his best at home to boot. Give me the Brew Crew here.

Chris Ruffolo's Free Pick: Milwaukee Brewers -123

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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