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Milwaukee Brewers vs St. Louis Cardinals 9/28/22 MLB Picks, Predictions, Odds

St. Louis Cardinals (90-65) vs. Milwaukee Brewers (82-72)
September 28, 2022 7:40 pm EDT
The Line: Milwaukee Brewers -146 / St. Louis Cardinals +124; Over/Under: +6.5
(Get latest betting odds)

The St. Louis Cardinals and Milwaukee Brewers meet Wednesday in MLB action at American Family Field. The St. Louis Cardinals need a win after losing 5 of their last 8 games. The Milwaukee Brewers look for a win after splitting their last 10 games.

The St. Louis Cardinals have scored 9 runs in their last 3 games and 3 or fewer runs in 6 of their last 9 games. The Cardinals have lost 5 straight games when scoring 3 or fewer runs. Paul Goldschmidt leads the Cardinals with 174 hits and 114 RBI, while Nolan Arenado and Tommy Edman have combined for 309 hits and 156 RBI. Jose Quintana gets the ball, and he is 6-6 with a 3.03 ERA and 130 strikeouts this season. Quintana is 9-4 with a 2.95 ERA and 111 strikeouts in his career against the Brewers.


The Milwaukee Brewers have scored 13 runs in their last 3 games and 4 or more runs in 8 of their last 11 games. The Brewers have won 6 of their last 8 games when scoring 4 or more runs. Christian Yelich leads the Brewers with 139 hits and 53 RBI, while Willy Adames and Andrew McCutchen have combined for 247 hits and 165 RBI. Brandon Woodruff gets the ball, and he is 12-4 with a 3.18 ERA and 173 strikeouts this season. Woodruff is 4-4 with a 3.02 ERA and 63 strikeouts in his career against the Cardinals.

The Cardinals are 6-2 in their last 8 Wednesday games and 36-17 in their last 53 overall. The Brewers are 11-5 in their last 16 home games and 4-1 in their last 5 overall. The under is 5-1 in Cardinals last 6 Wednesday games. The under is 4-1 in Brewers last 5 overall.

Jose Quintana has had his issues on the road this season, but he’s been ridiculous this month overall, allowing 2 runs in his last 25.1 innings. Brandon Woodruff has been great all season, he’s even better at home, and he’s had great success against the Cardinals for his career. With all that said, the Cardinals are the better team here, and getting them at plus money has value. The Brewers lose big games time and time again, and last night was another spot. Give me the Cards.

Randy Chambers's Free Pick: St. Louis Cardinals +124

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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