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Orioles vs Yankees Prediction 4/28/25 MLB Picks Today

NY Yankees (17-11) vs. Baltimore Orioles (10-17)
April 28, 2025 6:35 pm EDT
The Line: Baltimore Orioles 102 / NY Yankees -122; Over/Under: 10
(Get latest betting odds)

In this article, we will formulate an Orioles vs Yankees prediction for this MLB game on Monday, April 28, at Oriole Park at Camden Yards in Baltimore, Maryland. Let’s take a look at the prediction for this MLB matchup.

New York Yankees Betting Preview

The New York Yankees (17-11, 7-6 Away) bounced back from a series loss to the Cleveland Guardians with two wins in three games against the Toronto Blue Jays at home. Prior to that series, the Yankees swept the Royals and beat the Rays. In the latest 5-1 victory over the Jays, J.C. Escarra led the team with two RBI, while Clarke Schmidt pitched for 5.0 innings in a no-decision, allowing one run on one hit with six strikeouts and four walks. Tim Hill was credited with the win.


This season, the Yankees average 5.54 runs per game (2nd in the MLB) on a .262/.348/.468 slash line. Regarding pitching, the Yankees’ staff has a 3.70 ERA (11th) and 1.20 WHIP (7th). Aaron Judge leads the Yankees with a .406 batting average, eight home runs, and 27 RBI this season.

The projected starting pitcher for the Yankees is Will Warren, who is 1-0 in five starts this season, with a 4.79 ERA and 1.26 WHIP in 20.2 innings.

Baltimore Orioles Betting Preview

The Baltimore Orioles (10-17, 5-6 Home) are going through their worst stretch of the season after suffering six defeats in the previous seven games. After losing to the Reds and Nationals, the Orioles were swept in three games by the Detroit Tigers, scoring just five runs in the process. In the recent 7-0 loss, Dean Kremer took the L after allowing five runs on four hits with three strikeouts and four walks in 5.2 innings.

This year, the Orioles average 4.00 runs per game (19th in the MLB) on a .223/.297/.380 triple-slash. When it comes to pitching, the Orioles’ staff has a 5.37 ERA (30th) and 1.56 WHIP (29th). Cedric Mullins leads the Orioles with a .279 batting average, six home runs, and 20 RBI this season.

Tomoyuli Sugano will take the mound for the Orioles on Monday. The 35-year-old right-hander has a 2-1 record in five starts this year with a 3.54 ERA and 1.14 WHIP in 28.0 innings.

Total Runs Facts

  • Seven of the Orioles’ last eight home games after playing the previous day have gone OVER the total runs line.
  • Eight of the Yankees’ last 10 games as favorites against American League opponents have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Orioles’ last six games as home underdogs against American League opponents.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Yankees’ last six games at Oriole Park at Camden Yards.

Matchup/League Facts

  • The Orioles rank 29th in the league for strikeouts this season (186).
  • The Orioles rank 29th in the league for opponent batting average this season (.287).
  • The Yankees rank 1st in the league for on-base percentage this season (.348).
  • The Yankees rank 1st in the league for opponent batting average this season (.203).

Orioles vs Yankees Prediction

The Orioles won six of the previous ten H2H encounters, including three of the last four. Baltimore is not in a good place at the moment; the team is the worst defensive side in the MLB, but they will start Sugano here, who has been solid in his first MLB season. He hasn’t allowed more than three runs in a game yet, and logged 7.0 innings in each of his last two starts. Will Warren, on the other hand, also played well lately, so I am going with a low-scoring affair here. Give me the Under.

Oliver Zivic's Free Pick: Under 10

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Oliver Zivic

Professional journalist and expert bettor with 20+ years of experience. I cover Football (soccer), NFL, NBA, NHL, MLB, CFB, and CBB.

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