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Padres vs Rays Prediction 4/25/25 MLB Picks Today

Tampa Bay Rays (11-14) vs. San Diego Padres (17-8)
April 25, 2025 9:40 pm EDT
The Line: San Diego Padres -142 / Tampa Bay Rays 120; Over/Under: 7
(Get latest betting odds)

The Tampa Bay Rays and San Diego Padres meet Friday in MLB action at Petco Park. Here’s a Padres vs Rays Prediction. This article will include a Padres vs Rays Pick.

Tampa Bay Rays Betting Preview

The Tampa Bay Rays are 11-14 on the year and play the Royals, Yankees, and Phillies next. The Tampa Bay Rays are batting .255 on the season, have a .321 OBP, and a .397 slugging percentage. The Tampa Bay Rays pitching staff has a 3.75 ERA and a 1.17 WHIP. Yandy Diaz leads the Tampa Bay Rays with 26 hits and 12 RBI, while Junior Caminero and Jake Mangum have combined for 46 hits and 19 RBI.


Shane Baz gets the ball for the Tampa Bay Rays, and he is 2-0 with a 3.22 ERA and 30 strikeouts this season. This will be Baz’s second career game against the San Diego Padres.

San Diego Padres Betting Preview

The San Diego Padres are 17-8 on the year and play the Saints, Pirates, and Yankees next. The San Diego Padres are batting .263 on the season, have a .333 OBP, and a .401 slugging percentage. The San Diego Padres pitching staff has a 2.92 ERA and a 1.12 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 31 hits and 17 RBI while Manny Machado and Luis Arraez have combined for 51 hits and 17 RBI.

Michael King gets the ball for the San Diego Padres, and he is 3-0 with a 2.57 ERA and 31 strikeouts this season. King is 1-1 with a 6.38 ERA and 24 strikeouts in his career against the Tampa Bay Rays.

Why the San Diego Padres will win

  • The Padres have won each of their last 10 home games against teams that held a losing record.
  • The Rays have lost five of their last six games against National League opponents following a road win.
  • The Padres have covered the run line in each of their last 11 games at Petco Park.
  • The Rays have failed to cover the run line in three of their last four road games against NL West opponents following a win.
  • The Rays have lost the first inning in four of their last five games against opponents that held a winning record.
  • The Rays have trailed after 5 innings in each of their last six games.
  • The Padres have led after 3 innings in each of their last four night games against AL East opponents that held a losing record.

Why the Tampa Bay Rays will win

  • The Padres have lost eight of their last 10 games as favorites against American League opponents following a road loss.
  • The Rays have won three of their last four games as underdogs against National League opponents.
  • The Rays have covered the run line in each of their last six night games against National League opponents following a win.
  • The Padres have failed to cover the run line in 10 of their last 11 games as favorites against American League opponents following a road loss.
  • The Rays have led after 3 innings in each of their last three games at Petco Park against opponents that held a winning record.
  • The Padres have lost the first inning in three of their last four games as home favorites against AL East opponents.
  • The Padres have trailed after 5 innings in each of their last four night games at Petco Park against AL East opponents.

San Diego Padres Player Prop Facts

  • Xander Bogaerts has recorded at least one Double in three of his last four home appearances against AL East opponents that held a losing record.
  • Fernando Tatis Jr. has hit at least one home run in four of the Padres’ last five games as favorites.
  • Xander Bogaerts has recorded at least one RBI in seven of his last eight appearances against AL East opponents.
  • Fernando Tatis Jr. has scored at least one run in each of his four previous appearances against AL East opponents that held a losing record.
  • Manny Machado has recorded at least one Single in each of his last 11 appearances against AL East opponents that held a losing record.
  • Manny Machado has recorded at least one hit in each of his last 11 appearances against AL East opponents that held a losing record.
  • Fernando Tatis Jr. ranks T4th in the league in Home Runs (8) this season.

Tampa Bay Rays Player Prop Facts

  • Yandy Diaz has recorded at least one Double in three of the Rays’ last four road games against opponents that held a winning record.
  • Danny Jansen has scored a run in six of his last seven appearances with his team as an underdog against NL West opponents.
  • Yandy Diaz has recorded at least one RBI in four of the Rays’ last five night games against NL West opponents that held a winning record.
  • Yandy Diaz has recorded at least one Single in nine of his last 10 appearances against NL opponents that held a winning record.
  • Ha-Seong Kim has hit a home run in three of his last seven road appearances against NL West opponents.
  • Ha-Seong Kim has recorded at least one hit in each of his last six road appearances.
  • Jonathan Aranda ranks 9th amongst qualified players for Slugging Percentage (.600) this season.

Padres vs Rays Prediction

The Padres have cooled off after their 14-3 start, but they’re at home and have King on the mound. In his last 25.1 innings, King has allowed 16 hits and five runs while striking out 28. Baz was just tagged by the Yankees for five runs in 3.1 innings, and he has these games here and there where he has issues with his control. The Padres have still been one of the more impressive teams in baseball up to this point, and King is on a heater. The line is more than reasonable. Give me the Padres in game 1 against the Rays.

Randy Chambers's Free Pick: San Diego Padres -142

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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