Pirates vs Astros Prediction 6/4/25 MLB Picks Today

In this article, we will formulate a Pirates vs Astros prediction for this MLB game on Wednesday, June 4th at PNC Park in Pittsburgh, Pennsylvania. Let’s take a look at the prediction for this MLB matchup. 

Pittsburgh Pirates Betting Preview

The Pittsburgh Pirates are 22-39 this year after they lost game one by a score of 3-0 on Tuesday night. Pittsburgh got another great outing from Skenes on the mound, but they didn’t score any runs in the shutout loss. The Pirates recorded four hits and they committed one error in the game, while they were led by Kiner-Falefa, who went 2-3 in the loss. Pittsburgh started Skenes, who allowed three hits and one earned run over 8.0 innings for the loss, while Santana allowed two earned runs in just 0.1 innings. 

Prior to this series, the Pirates lost two out of three against the Padres, but did win two out of three against the Diamondbacks before that. Pittsburgh has lost three of its last five games, and they are currently last in the NL Central standings. The Pittsburgh pitching staff has a 3.94 ERA with a 1.24 WHIP and a .237 opponent batting average, while their offense has scored 194 runs with a .226 batting average and a .304 on-base percentage this season. Oneil Cruz has led Pittsburgh with 12 home runs and 26 RBIs, while Bryan Reynolds has added seven home runs and 34 RBIs this year. The projected starting pitcher for Pittsburgh is Mike Burrows, who is 0-1 with an 8.64 ERA and a 1.56 WHIP over 8.1 innings pitched this year. 

Houston Astros Betting Preview

The Houston Astros are 33-27 this season after they won game one in this series on Tuesday night. Houston scored once in the seventh inning and twice in the ninth inning to secure the low-scoring victory. The Astros recorded five hits and they committed one error in the game, while they were led by Paredes, who went 1-4 with one home run and two RBIs in the win. Houston started McCullers Jr., who allowed two hits and zero earned runs over 6.0 innings for the win, while Hader recorded the save. 

Prior to this series, the Astros split four games with the Rays and won both games against the Athletics. Houston has won seven of their last nine games, and they are currently first in the AL West standings. The Houston pitching staff has a 3.59 ERA with a 1.16 WHIP and a .219 opponent batting average, while their offense has scored 242 runs with a .252 batting average and a .319 on-base percentage this season. Isaac Paredes has led Houston with 12 home runs and 34 RBIs, while Jeremy Pena has added nine home runs and 30 RBIs this year. The projected starting pitcher for Houston is Ryan Gusto, who is 3-2 with a 4.62 ERA and a 1.56 WHIP over 39.0 innings pitched this season. 

Why the Astros will beat the Pirates

• The Pirates have lost each of their last nine Wednesday night games against American League opponents that held a winning record.
• The Astros have won four of their last five games at PNC Park.
• The Pirates have failed to cover the run line in each of their last 10 Wednesday night home games against American League opponents.
• The road team has covered the run line in eight of the last nine games between the Astros and Pirates.
• The Pirates have lost the first inning in three of their last four games as home underdogs against AL West opponents.
• The Pirates have trailed after 5 innings in five of their last six games as home underdogs against American League opponents.
• The Astros have led after 3 innings in four of their last five games as favorites against NL Central opponents.

Total Runs Facts

• Six of the Pirates’ last seven games against AL West opponents have gone UNDER the total runs line.
• Six of the Astros’ last seven games as road favorites have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the last five games between the Astros and Pirates.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last four games as favorites.

Pittsburgh Pirates Player Prop Facts

• Oneil Cruz has hit a home run in three of the Pirates’ last four games as underdogs against AL opponents.
• Isiah Kiner-Falefa has recorded at least one Single in 16 of his last 17 appearances in night games against AL teams that held a winning record.
• Oneil Cruz has scored at least one run in each of the Pirates’ last four games as underdogs against AL opponents.
• Jared Triolo has recorded at least one hit in each of his last nine appearances in night games against AL teams that held a winning record.
• Joey Bart has recorded at least one RBI in each of his last four appearances against AL West opponents that held a winning record.
• Jared Triolo has recorded a Double in each of his three previous appearances against the Astros.

Houston Astros Player Prop Facts

• Isaac Paredes has hit at least one home run in four of the Astros’ last five road games.
• Isaac Paredes has recorded a Double in each of the Astros’ last three games as favorites against NL Central opponents.
• Isaac Paredes has recorded at least one RBI in four of the Astros’ last five games against NL Central opponents.
• Christian Walker has scored a run in each of the Astros’ last four games against NL Central opponents.
• Jeremy Pena has recorded at least one Single in each of the Astros’ last six games against NL opponents that held a losing record.
• Isaac Paredes has recorded at least one hit in each of his last nine road appearances against opponents that held a losing record.

Pirates vs Astros Prediction

Houston was able to escape with a win in game one of this series, despite a dominant outing from Skenes, and they will look for their third straight win here. The Astros are 11-15 on the road this season, while the Pirates are 13-17 at home. Pittsburgh has played better over the last two weeks, but its offense continues to be a huge issue. The Pirates are starting Burrows, who has allowed four earned runs in each of his first two starts. The Astros are going with Gusto, who has allowed four earned runs over his last two starts (8.0 IP). I don’t have much faith in either pitcher in this contest, but I will continue to fade the Pittsburgh offense. Take the Astros here.