Padres vs Dodgers Prediction 8/22/25 MLB Picks Today

The Los Angeles Dodgers and the San Diego Padres meet Friday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Padres vs Dodgers Prediction.

Starting Pitching Matchup

The Los Angeles Dodgers will start Blake Snell here and Snell is 3-1 with a 1.80 ERA and 25 strikeouts this season. In his career, Snell is 2-0 with a 0.82 ERA and 11 strikeouts against the Padres. Yu Darvish will start for the Padres and is 2-3 with a 5.97 ERA and 34 strikeouts this season. In his last five starts against the Dodgers, Darvish is 1-0 with a 3.04 ERA and 21 strikeouts.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to build on their 9-5 win over the Colorado Rockies last time out to sit at 73-55 this season. After this series, the Dodgers will head on the road for a series against the Cincinnati Reds.

Dodgers Win 5 Of Their Last 7

Shohei Ohtani has 138 hits including 17 doubles, 44 home runs, 83 RBIs and 8 triples while Tommy Edman has 69 hits with 12 home runs and 44 RBIs. Michael Conforto has 63 hits with 18 doubles while Teoscar Hernandez has 101 hits with 21 home runs, 24 doubles and 76 RBIs as well this season. Ohtani has a team-high 17 stolen bases while Max Muncy has 10 doubles but also has 73 strikeouts so far this season. Mookie Betts has also chipped in 13 home runs and 57 RBIs as well on the year. Freddie Freeman has also logged 131 hits with a team-high 32 doubles, 16 home runs and 72 RBIs. Andy Pages also has 127 hits with 21 doubles, 21 home runs and 71 RBIs as well this season.

Why the Los Angeles Dodgers will win

• The Dodgers have won seven of their last eight games against the Padres.
• The Padres have lost seven of their last eight games against the Dodgers following a win.
• The Padres have failed to cover the run line in five of their last six home games against the Dodgers following a home win.
• The road team has covered the run line in four of the last five games between the Dodgers and Padres.

Los Angeles Dodgers Player Prop Facts

• Miguel Rojas has recorded at least one hit in each of his last 12 appearances with the Dodgers as road favorites against NL West opponents.
• Blake Snell has recorded six or more strikeouts in each of his last 14 appearances with his team as a road favorite against NL opponents.
• Blake Snell has recorded a win in each of his last five appearances against opponents that held a winning record.
• Tommy Edman has hit a home run in each of his last two appearances in night games against NL teams that held a winning record.
• Will Smith has recorded a Double in three of his last four road appearances against NL opponents that held a winning record.
• Shohei Ohtani ranks 2nd amongst qualified players for Slugging Percentage (.625) this season.

San Diego Padres Recap

The San Diego Padres come into this game looking to add on to their 8-4 win over the San Francisco Giants last time out to sit at 72-56 this season. After this series, the Padres will head on the road for a series against the Seattle Mariners.

Padres Win Three Straight

Manny Machado has 145 hits including a team-high 32 doubles, 21 home runs, 77 RBIs and 12 stolen bases while Fernando Tatis Jr. has 128 hits with 17 home runs and 52 RBIs along with 25 stolen bases of his own this season. Luis Arraez has added 144 hits with 27 doubles, 4 triples, 6 home runs and 47 RBIs while Jackson Merrill’s added 91 hits with 9 home runs and 51 RBIs as well. Xander Bogaerts also has 28 doubles and 19 stolen bases as well this season. Gavin Sheets also has 18 doubles, 17 home runs and 58 RBIs as well this season.

Why the San Diego Padres will win

• The Dodgers have lost each of their last four games as road favorites following a win.
• The Padres have won four of their last five games as home underdogs.
• The Padres have covered the run line in each of their last 10 games as underdogs against National League opponents following a win.
• The Dodgers have failed to cover the run line in each of their last seven games following a road win.

San Diego Padres Player Prop Facts

• Manny Machado has hit a home run in three of the Padres’ last five games as home underdogs.
• Yu Darvish has recorded five or more strikeouts in 13 of his 14 previous home appearances against NL West opponents that held a winning record.
• Luis Arraez has recorded at least one Double in four of the Padres’ last five games against opponents that held a winning record.
• Yu Darvish has recorded a win in three of his last four home appearances against NL opponents that held a winning record.
• Gavin Sheets has recorded at least one hit in each of his last 12 appearances against NL West opponents that held a winning record.
• Manny Machado ranks 4th in the league in Hits (145) this season.

Total Runs Facts

• Fourteen of the Padres’ last 15 night games as underdogs have gone UNDER the total runs line.
• Four of the Dodgers’ last five night games against NL West opponents have gone UNDER the total runs line.

Padres vs Dodgers Prediction

I’m looking at the Padres in this one. I think the Dodgers are still a solid team with a loaded roster, but the problem is they’re coming off of a series at Coors Field with no day off in between to reacclimate to the altitude change. The Padres have still been a solid lineup that’s out for some revenge after being swept in the last series between these two teams last week. I think we have a nice spot to back the Padres in this one, so give me San Diego.