Seattle Mariners vs Houston Astros Prediction 4/13/26 MLB Picks Today

The Houston Astros and the Seattle Mariners meet Monday in MLB action from T-Mobile Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. Seattle Mariners prediction.

Starting Pitching Matchup

The Houston Astros will send out Mike Burrows for the start here and Burrows is 1-2 with a 5.63 ERA and 15 strikeouts this season. This will be Burrows’ second career start against the Mariners. George Kirby will start here for the Mariners and is 1-2 with a 3.60 ERA and 16 strikeouts this season. In his last five starts against the Astros, Kirby is 2-1 with a 2.60 ERA and 31 strikeouts.

Houston Astros Recap

The Houston Astros come into this game looking to bounce back from a 6-1 loss at the hands of the Mariners last time out to sit at 6-10 this season. After this series, the Astros will head home for a series against the Colorado Rockies.

Astros Lose 7 In A Row

Yordan Alvarez has 18 hits with 4 doubles, 6 home runs and 14 RBIs while Christian Walker has 17 hits with 6 doubles, 3 home runs and 13 RBIs on the year. Jose Altuve’s chipped in 19 hits with 5 doubles, 2 home runs and 6 RBIs and Carlos Correa has 15 hits with 3 doubles, a home run and 9 RBIs. Cam Smith also has 16 hits with 4 doubles, 3 home runs and 8 RBIs. Yainer Diaz also has 10 hits with a double, a home run and 8 RBIs.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to add on to their win over the Astros from Sunday to sit at 7-9 on the year. After this series, the Mariners will head on the road for a set against the San Diego Padres.

Mariners Looking For Sweep

Brendan Donovan has 12 hits with 2 doubles, 3 home runs and 6 RBIs while Luke Raley has 3 home runs and 9 RBIs this season. Cole Young’s added 14 hits with 2 doubles, a triple, 2 home runs and 8 RBIs and Cal Raleigh has 8 hits with 2 doubles, 2 home runs and 10 RBIs as well this season. Randy Arozarena has 16 hits with 3 doubles, a home run and 7 RBIs as well on the year.

Houston Astros @ Seattle Mariners Betting Trends: April 13, 2026

• Probable Starting Pitcher: George Kirby      Record this season: 1-2      ERA: 3.60
• Home Record: 1-1
• Last 5 against Astros: 2-1

Why the Seattle Mariners will win

• The Mariners have won each of their last 13 home games against teams that held a losing record.
• The Astros have lost each of their last seven games.
• The Astros have failed to cover the run line in six of their last seven games.
• The Mariners have covered the run line in five of their last six games against the Astros.
• The Mariners have won the first inning in each of their last five home games against AL West opponents.
• The Mariners have led after 5 innings in each of their last four day games at T-Mobile Park against AL West opponents.
• The Mariners have led after 3 innings in four of their last five day games against opponents that held a losing record.

• Probable Starting Pitcher: Mike Burrows      Record this season: 1-2      ERA: 5.63
• Road Record: 0-1
• Last 5 against Mariners: 0-0

Why the Houston Astros will win

• The Astros have won 11 of their last 12 day games against AL West opponents following a road loss.
• The Mariners have lost 10 of their last 14 games as favorites after playing the previous day.
• The Astros have covered the run line in each of their last nine Monday games as underdogs against AL West opponents.
• The Mariners have failed to cover the run line in six of their last seven games as favorites after playing the previous day.
• The Mariners have trailed after 5 innings in three of their last four day games.

Total Runs Facts

• Ten of the Astros’ last 11 games against American League opponents have gone OVER the total runs line.
• Five of the Mariners’ last six games as home favorites have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last seven games as underdogs.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Mariners’ last eight games.

Seattle Mariners Player Prop Facts

• Cal Raleigh has hit a home run in three of the Mariners’ last five games against the Astros.
• George Kirby has recorded a win in each of his last six appearances in day games against AL West teams that held a losing record.
• George Kirby has recorded six or more strikeouts in each of his last four appearances in day games.
• Victor Robles has recorded at least one hit in each of his last nine appearances in day games against teams that held a losing record.

Houston Astros Player Prop Facts

• Yordan Alvarez has hit a home run in three of the Astros’ last four games against AL West opponents.
• Jose Altuve has recorded at least one hit in each of his last 19 road appearances against the Mariners after playing the previous day.
• Yordan Alvarez ranks T1st amongst qualified players for On Base Percentage (.500) this season.

Matchup/League Facts

• The Mariners rank 29th in the league for batting average this season (.198).
• The Mariners rank 29th in the league for slugging percentage this season (.324).
• The Astros rank 1st in the league for runs scored this season (93).
• The Astros rank 1st in the league for hits this season (152).

Houston Astros vs. Seattle Mariners Prediction

I’m on the Mariners here. I just think George Kirby is the more trustworthy starting option in this game, and right now, there’s just no backing the Houston Astros until they get out from under this slump. Seattle has woken up offensively in this series, and I think the Mariners complete the sweep here.