St. Louis Cardinals vs Arizona Diamondbacks Prediction 6/25/26 MLB Picks Today

The Arizona Diamondbacks and the St. Louis Cardinals meet Thursday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Diamondbacks vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Arizona Diamondbacks will send out Zac Gallen for the start here and Gallen is 3-6 with a 6.10 ERA and 52 strikeouts this season. Michael McGreevy will start for St. Louis and is 3-6 with a 3.35 ERA and 53 strikeouts this season.

Arizona Diamondbacks Recap

The Arizona Diamondbacks come into this game looking to add on to their 9-4 win over St. Louis last time out to sit at 41-39 this season. After this series, the Diamondbacks will head on the road for a series against the Tampa Bay Rays.

Diamondbacks Pick Up Back-To-Back Wins

Corbin Carroll has 77 hits including 16 doubles, 9 triples, 13 home runs and 42 RBIs. Ketel Marte has 76 hits with 16 doubles, 12 home runs and 46 RBIs and Geraldo Perdomo has 61 hits, with 10 doubles, 3 triples, 4 home runs and 27 RBIs as well this season. Nolan Arenado also has 58 hits with 12 doubles, 8 home runs and 31 RBIs and Jose Fernandez has 42 hits with 3 home runs and 15 RBIs this season. Ildemaro Vargas also has 63 hits with 10 doubles, 2 triples, 7 home runs and 42 RBIs.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to rebound from their loss at the hands of the Diamondbacks on Wednesday to fall to 42-36 this season. After this series, the Cardinals will take on the Miami Marlins in a series at home.

Cardinals Drop Back-To-Back Games

Jordan Walker leads the Cardinals with 85 hits, 16 doubles, 18 home runs and 58 RBIs while Alec Burleson has 84 hits with 19 doubles, 13 home runs and 55 RBIs. JJ Wetherholt has 74 hits with 12 home runs and 34 RBIs while Ivan Herrera has 73 hits with 13 doubles, 10 home runs and 38 RBIs. Nolan Gorman has 39 hits with 7 home runs and 26 RBIs this season. Masyn Winn’s added 62 hits with 11 doubles and 31 RBIs and Nathan Church has 47 hits with 5 home runs and 19 RBIs this season.

Arizona Diamondbacks @ St. Louis Cardinals Betting Trends: June 25, 2026

• Probable Starting Pitcher: Michael McGreevy      Record this season: 3-6      ERA: 3.35
• Home Record: 1-2
• Last 5 against Diamondbacks: –

Why the St. Louis Cardinals will win

• The Cardinals have won eight of their last nine night games against NL West opponents that held a winning record.
• The Diamondbacks have lost four of their last five games against National League opponents following a win.
• The Cardinals have covered the run line in 19 of their last 22 night games against NL West opponents following a loss.
• The Diamondbacks have failed to cover the run line in six of their last eight games following a win.
• The Diamondbacks have trailed after 3 innings in 10 of their last 11 games as underdogs against NL Central opponents.
• The Diamondbacks have trailed after 5 innings in each of their last seven Thursday games as underdogs.

• Probable Starting Pitcher: Zac Gallen      Record this season: 3-6      ERA: 6.10
• Road Record: 0-3
• Last 5 against Cardinals: 1-2

Why the Arizona Diamondbacks will win

• The Diamondbacks have won each of their last eight night games against National League opponents following a road win.
• The Cardinals have lost four of their last five games as favorites after playing the previous day.
• The Diamondbacks have covered the run line in each of their last eight games against the Cardinals.
• The Cardinals have failed to cover the run line in each of their last seven games after playing the previous day.
• The Diamondbacks have led after 5 innings in seven of their last nine night games against the Cardinals at Busch Stadium.

Total Runs Facts

• Eleven of the Cardinals’ last 12 games against NL West opponents have gone UNDER the total runs line.
• Ten of the Diamondbacks’ last 11 road games after playing the previous day have gone UNDER the total runs line.
• There has been no run scored during the first inning in each of the Diamondbacks’ last six games as road underdogs against NL Central opponents.
• There has been no run scored during the first inning in each of the Cardinals’ last six night games against NL West opponents.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in four of the Cardinals’ last 11 night games.
• Michael McGreevy has recorded a win in each of his last three appearances against NL West opponents.
• Michael McGreevy has recorded five or more strikeouts in three of his last four appearances against NL opponents.
• Masyn Winn has recorded at least one hit in each of his last 10 home appearances against NL West opponents.
• Jordan Walker ranks T6th in the league in Hits (88) this season.

Arizona Diamondbacks Player Prop Facts

• Ketel Marte has hit a home run in three of his last six appearances in night games against teams that held a winning record.
• Zac Gallen has recorded a win in three of his last four appearances in night games against NL Central teams that held a winning record.
• Zac Gallen has recorded four or more strikeouts in 35 of his 38 previous appearances against NL Central opponents.
• Gabriel Moreno has recorded at least one hit in each of his last nine appearances.
• Corbin Carroll is one of only two players to record 10+ Home Runs and 4+ Triples this season.

Matchup/League Facts

• The Cardinals rank 28th in the league for strikeouts this season (587).
• The Cardinals rank 4th in the league for strikeouts against this season (607).
• The Diamondbacks rank 1st in the league for triples this season (19).
• The Diamondbacks rank 30th in the league for strikeouts this season (556).

Arizona Diamondbacks vs. St. Louis Cardinals Prediction

I’m on St. Louis here. Zac Gallen has been borderline auto-fade for me on the road this season as he continues to have issues and I’m looking for more of the same in this one. St. Louis still has some solid numbers against right-handed pitching in the month of June and Michael McGreevy has been much better at home in 2026. I’ll back St. Louis here.