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Tigers vs Brewers Prediction 4/22/26 MLB Picks Today

Milwaukee Brewers (13-9) vs. Detroit Tigers (12-12)
April 22, 2026 6:40 pm EDT
The Line: Detroit Tigers 0.0001 / Milwaukee Brewers 0.0001; Over/Under: 0.0001
(Get latest betting odds)

The Milwaukee Brewers and Detroit Tigers meet Wednesday in MLB action at Comerica Park. Here’s a Tigers vs. Brewers Prediction. This article will include a Tigers vs. Brewers Pick.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers are 13-9 on the year and play the Pirates and Diamondbacks next. The Milwaukee Brewers are batting. 241 on the season, have a .331 OBP, and have a .376 slugging percentage. The Milwaukee Brewers pitching staff has a 3.86 ERA and a 1.32 WHIP. William Contreras leads the Milwaukee Brewers with 24 hits and 13 RBI, while Brice Turang and Jake Bauers have combined for 40 hits and 32 RBI.

Chad Patrick gets the ball for the Milwaukee Brewers, and he is 1-0 with a 0.95 ERA and 9 strikeouts this season. This will be Patrick’s first career game against the Detroit Tigers.

Detroit Tigers Betting Preview

The Detroit Tigers are 12-12 on the year and play the Braves and Reds next. The Detroit Tigers are batting .246 on the season and have a .327 OBP, and a .378 slugging percentage. The Detroit Tigers pitching staff has a 3.70 ERA and a 1.30 WHIP. Kevin McGonigle leads the Detroit Tigers with 28 hits and 10 RBI, while Gleyber Torres and Riley Greene have combined for 43 hits and 21 RBI.

Casey Mize gets the ball for the Detroit Tigers, and he is 1-1 with a 2.78 ERA and 25 strikeouts this season. This will be Mize’s second career game against the Milwaukee Brewers.

Why the Detroit Tigers will win

  • The Tigers have won six of their last seven home games.
  • The Brewers have lost four of their last five games against American League opponents following a road win.
  • The Brewers have failed to cover the run line in each of their last six games against the Tigers following a road win.
  • The Tigers have covered the run line in six of their last seven home games against teams that held a winning record.
  • The Tigers have led after 3 innings in five of their last six games against National League opponents.
  • The Tigers have led after 5 innings in six of their last seven games against National League opponents that held a winning record.

Why the Milwaukee Brewers will win

  • The Brewers have won each of their last six games as road underdogs against AL Central opponents.
  • The Tigers have lost each of their last six games as favorites following a home loss.
  • The Brewers have covered the run line in each of their last nine games as road underdogs against American League opponents following a win.
  • The Tigers have failed to cover the run line in each of their last six games as favorites following a home loss.
  • The Brewers have led after 3 innings in each of their last four games as underdogs against AL Central opponents.
  • The Brewers have led after 5 innings in each of their last five games as underdogs against AL Central opponents.

Total Runs Facts

  • Each of the last four games between the Brewers and Tigers at Comerica Park has gone OVER the total runs line.
  • Each of the Brewers’ last four games as underdogs against the Tigers has gone OVER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Tigers’ last six night games at Comerica Park.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Brewers’ last nine games as road underdogs against American League opponents.

Detroit Tigers Player Prop Facts

  • Kerry Carpenter has hit a home run in two of the Tigers’ last three games against NL Central opponents.
  • Casey Mize has recorded five or more strikeouts in each of his last four home appearances.
  • Colt Keith has recorded at least one hit in each of his last 11 appearances with the Tigers as favorites against NL opponents.
  • Kevin McGonigle ranks 10th amongst qualified players for Batting Average (.322) this season.

Milwaukee Brewers Player Prop Facts

  • Luis Rengifo has hit a home run in each of his last two appearances against the Tigers after playing the previous day.
  • Sal Frelick has recorded at least one hit in each of his last nine road appearances.
  • Garrett Mitchell ranks 4th amongst qualified players for On-Base Percentage (.437) this season.

Matchup/League Facts

  • The Tigers rank T1st in the league for home runs allowed this season (13).
  • The Tigers rank T2nd in the league for doubles this season (48).
  • The Brewers rank 1st in the league for steals this season (33).
  • The Brewers rank T3rd in the league for triples this season (4).

Tigers vs Brewers Prediction

The Tigers are going to get the benefit of the doubt at home and Mize has pitched well this season. However, the Brewers are playing better baseball right now and Patrick has been even better. Through 19 innings, Patrick has a 0.95 ERA and 1.16 WHIP. That’s about as good as it gets, folks. The Brewers have also won 5 of their last 6 games overall with an improved effort offensively. Give me the plus money with the Brewers.

Randy Chambers's Free Pick: Milwaukee Brewers

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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