White Sox vs Twins Prediction 5/25/26 MLB Picks Today
Minnesota Twins (26-27) vs. Chicago White Sox (26-26)
May 25, 2026 2:10 pm EDT
The Line: Chicago White Sox -106 / Minnesota Twins -114; Over/Under: 8
(Get latest betting odds)
The Minnesota Twins and Chicago White Sox meet Monday in MLB action at Rate Field. Here’s a White Sox vs. Twins Prediction. This article will include a White Sox vs. Twins Pick.
Minnesota Twins Betting Preview
The Minnesota Twins are 26-27 on the year and play the White Sox and Pirates next. The Minnesota Twins are batting .240 on the season and have a .325 OBP, and a .389 slugging percentage. The Minnesota Twins pitching staff has a 4.19 ERA and a 1.32 WHIP. Byron Buxton leads the Minnesota Twins with 49 hits and 26 RBI, while Brooks Lee and Josh Bell have combined for 87 hits and 56 RBI.
Zebby Matthews gets the ball for the Minnesota Twins, and he is 1-1 with a 1.38 ERA and 11 strikeouts this season. Matthews is 0-0 with a 4.22 ERA and 9 strikeouts in his career against the Chicago White Sox.
Chicago White Sox Betting Preview
The Chicago White Sox are 26-26 on the year and play the Twins and Tigers next. The Chicago White Sox are batting .232 on the season, have a .322 OBP, and have a .399 slugging percentage. The Chicago White Sox pitching staff has a 4.54 ERA and a 1.37 WHIP. Chase Meidroth leads the Chicago White Sox with 48 hits and 13 RBI, while Munetaka Murakami and Miguel Vargas have combined for 87 hits and 67 RBI.
Anthony Kay gets the ball for the Chicago White Sox, and he is 3-1 with a 4.27 ERA and 34 strikeouts this season. This will be Kay’s first career game against the Minnesota Twins.
Why the Chicago White Sox will win
- The White Sox have won each of their last six games as underdogs against the Twins.
- The Twins have lost nine of their last 10 games as favorites against AL Central opponents.
- The White Sox have covered the run line in each of their last six games against the Twins.
- The Twins have failed to cover the run line in nine of their last 10 games as favorites against AL Central opponents.
- The White Sox have led after 5 innings in seven of their last eight home games against AL Central opponents.
- The Twins have lost the first inning in three of their last four games as road favorites against American League opponents.
- The Twins have trailed after 3 innings in each of their last nine games as road favorites against American League opponents.
Why the Minnesota Twins will win
- The Twins have won each of their last six day games after playing the previous day.
- The White Sox have lost 13 of their last 14 games against the Twins following a road loss.
- The Twins have covered the run line in seven of their last eight games.
- The White Sox have failed to cover the run line in eight of their last nine games against the Twins following a road loss.
- The Twins have led after 3 innings in four of their last five day games.
- The Twins have led after 5 innings in six of their last seven day games against American League opponents.
- The Twins have won the first inning in three of their last four day games.
Total Runs Facts
- Each of the White Sox’s last six home games have gone OVER the total runs line.
- Seven of the Twins’ last eight games as road favorites have gone OVER the total runs line.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in each of Anthony Kay’s last six home appearances as a starter.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of Zebby Matthews’ last eight road appearances as a starter.
Chicago White Sox Player Prop Facts
- Miguel Vargas has hit a home run in two of the White Sox’s last three home games.
- Miguel Vargas has recorded at least one hit in each of the White Sox’s last 12 home games.
- Munetaka Murakami ranks T2nd in the league in Home Runs (17) this season.
Minnesota Twins Player Prop Facts
- Byron Buxton has hit a home run in three of his last five road appearances.
- Ryan Jeffers has recorded at least one hit in 12 of his last 13 road appearances against AL Central opponents.
- Byron Buxton ranks T4th in the league in Home Runs (16) this season.
Matchup/League Facts
- The White Sox rank 30th in the league for doubles this season (63).
- The White Sox rank 28th in the league for hits this season (397).
- The Twins rank T5th in the league for home runs allowed this season (46).
- The Twins rank T6th in the league for RBIs this season (234).
White Sox vs Twins Prediction
The Twins have put together a nice little winning streak but there are questions about how long it will last. The Twins have underachieved for the most part up to this point and while Matthews has been solid, he’s pitched just 13 innings. The White Sox have had value up to this point and they’ve played their best ball at home. The White Sox have won 6 of the last 9 games Kay has pitched and through 22 home innings he has a 3.68 ERA. Give me the White Sox at home with the cheap price, as I simply trust them more.