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Tigers vs Red Sox Prediction 5/5/26 MLB Picks Today

Boston Red Sox (14-21) vs. Detroit Tigers (18-18)
May 5, 2026 6:40 pm EDT
The Line: Detroit Tigers -186 / Boston Red Sox 153; Over/Under: 8
(Get latest betting odds)

In this article we will formulate a Tigers vs Red Sox prediction for this MLB game on Tuesday, May 5th at Comerica Park in Detroit, Michigan. Let’s take a look at the prediction for this MLB matchup. 

Detroit Tigers Betting Preview

The Detroit Tigers are 18-18 this season after they lost game one by a score of 5-4 on Monday night. Detroit led 2-0 in the sixth inning, but they allowed five runs in the seventh for the loss. The Tigers recorded three hits and they committed one error in the game, while they were led by Dingler, who went 1-4 with two RBIs. Madden allowed four hits and zero earned runs over 5.0 innings, while Vanasco allowed four earned runs for the loss. Prior to this series, Detroit won two out of three against the Rangers, but lost two out of three against the Braves before that. 

This season, Detroit has a 3.84 ERA with a 1.32 WHIP and a .241 opponent batting average, while they have scored 162 runs with a .247 batting average and a .328 on base percentage. Dillon Dingler has led the Tigers with six home runs and 25 RBIs, while Riley Greene has added four home runs and 19 RBIs. The projected starting pitcher for Detroit is Framber Valdez, who is 2-1 with a 3.35 ERA and a 1.26 WHIP over 40.1 innings pitched this season. 

Boston Red Sox Betting Preview

The Boston Red Sox are 14-21 this year after they won game one by a score of 5-4 last night. Boston scored five runs in the seventh inning, but barely hung on for the close win. The Red Sox recorded 12 hits and they committed two errors, while they were led by Duran, who went 3-5 with one home run and three RBIs in the game. Tolle allowed one hit and zero earned runs over 7.0 innings for the win, while Chapman picked up the save. Prior to this series, Boston lost two out of three against the Astros and two out of three against the Blue Jays. 

This season, Boston has a 4.14 ERA with a 1.31 WHIP and a .247 opponent batting average, while they have scored 135 runs with a .237 batting average and a .316 on base percentage. Willson Contreras has led the Red Sox with seven home runs and 21 RBIs, while Jarren Duran has added four home runs and 18 RBIs. The projected starting pitcher for Boston is Jovani Moran, who is 0-0 with a 2.33 ERA and a 1.09 WHIP over 19.1 innings pitched this year. 

Why the Detroit Tigers will win

  • The Tigers have won each of their last eight games as favorites against the Red Sox following a loss.
  • The Red Sox have lost each of their last seven games as underdogs against the Tigers following a win.
  • The Red Sox have failed to cover the run line in each of their last six night games against AL Central opponents.
  • The Tigers have covered the run line in seven of their last eight games against the Red Sox.
  • The Red Sox have lost the first inning in three of their last four road games against AL Central opponents.
  • The Tigers have led after 3 innings in four of their last five games as favorites against AL East opponents.
  • The Tigers have led after 5 innings in four of their last five games as home favorites.

Why the Boston Red Sox will win

  • The Tigers have lost four of their last five games as home favorites against AL East opponents.
  • The Red Sox have won four of their last six games as underdogs against AL Central opponents following a road win.
  • The Tigers have failed to cover the run line in each of their last 11 Tuesday games as favorites.
  • The Red Sox have covered the run line in each of their last seven games as road underdogs against AL Central opponents.
  • The Tigers have trailed after 5 innings in each of their last five Tuesday home games.

Total Runs Facts

  • Each of the last four games between the Red Sox and Tigers at Comerica Park have gone OVER the total runs line.
  • Five of the Red Sox’s last six road games against AL Central opponents have gone OVER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of Brayan Bello’s last seven appearances as a starter.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Tigers’ last eight Tuesday night games.

Detroit Tigers Player Prop Facts

  • Spencer Torkelson has hit a home run in each of his last two appearances with the Tigers as home favorites against the Red Sox.
  • Framber Valdez has recorded six or more strikeouts in each of his last four home appearances against AL East opponents.
  • Javier Baez has recorded at least one hit in each of his last nine appearances against AL East opponents.
  • Framber Valdez has recorded a win in three of his last four appearances against the Red Sox.

Boston Red Sox Player Prop Facts

  • Jarren Duran has hit a home run in three of the Red Sox’s last four games.
  • Trevor Story has recorded at least one hit in each of his last eight road appearances after playing the previous day.

Tigers vs Red Sox Prediction 

Detroit really struggled to get anything going at the plate on Monday night and their bullpen fell apart, but they have been very good at home. The Tigers are 12-4 at home this year, while the Red Sox are 8-11 on the road. Boston has split their last four games, but they have scored three runs or fewer in four of their last five. The Red Sox are starting Moran, who will serve as an opener, while Valdez has allowed two earned runs or fewer in four straight starts for the Tigers. Take Detroit -1.5 here. 

David Racey's Free Pick: Tigers -1.5

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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