Tigers vs White Sox Prediction 4/6/25 MLB Picks Today

The Chicago White Sox and the Detroit Tigers meet Sunday in MLB action from Comerica Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs. Detroit Tigers prediction.

Starting Pitching Matchup

Martin Perez will get the start for the White Sox and is 1-0 with a 0.00 ERA and 9 strikeouts this season. In his last five starts against the Tigers, Perez is 0-0 with a 2.81 ERA and 24 strikeouts. Jackson Jobe will get the start for the Tigers here and is 0-0 with a 6.75 ERA and 3 strikeouts this season. This will be Jobe’s first career start against the White Sox.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to avoid the sweep after falling short in Saturday’s matchup by a final score of 7-2 to drop to 2-7 on the year. After this series, the White Sox will head on the road for a series against the Cleveland Guardians.

White Sox Drop 4^th Game In A Row

Andrew Benintendi leads the White Sox with 9 hits including 2 home runs, 6 RBIs and a .310 batting average while Miguel Vargas, Korey Lee and Andrew Vaughn each have a pair of doubles while Nick Maton has a pair of home runs as well this season. Brooks Baldwin has 5 RBIs while Vaughn has 4 RBIs.

Why the Chicago White Sox will win

• The White Sox have won seven of their last nine games as underdogs against the Tigers following a road loss.
• The Tigers have lost three of their last four games as favorites after playing the previous day.
• The White Sox have covered the run line in eight of their last nine games as underdogs against the Tigers following a road loss.
• The Tigers have failed to cover the run line in 10 of their last 12 games as home favorites against the White Sox following a win.

Chicago White Sox Player Prop Facts

• Martin Perez has recorded five or more strikeouts in four of his last five appearances against AL Central opponents.
• Andrew Benintendi has hit a home run in two of his last three appearances against the Tigers after playing the previous day.
• Andrew Benintendi has recorded at least one Single in each of the White Sox’s last four games.
• Mike Tauchman has recorded at least one RBI in three of his last four appearances in day games.
• Luis Robert has scored a run in four of his last five appearances against the Tigers.
• Andrew Vaughn has recorded a hit in each of his last six appearances after playing the previous day.
• Martin Perez has recorded a win in three of his last four appearances against AL opponents.

Detroit Tigers Recap

The Detroit Tigers come into this game looking to complete the sweep after ending up with the win on Saturday to improve to 4-4 on the year. After this game, the Tigers will welcome the New York Yankees to town for a series.

Tigers Win Back-To-Back Series

Riley Greene has a team-high 13 hits including 4 doubles, 3 home runs and 5 RBIs along with 11 strikeouts while Kerry Carpenter has 3 home runs and a team-high 8 RBIs as well on the year. Spencer Torkelson’s added 10 hits with 3 doubles, 2 home runs and 4 RBIs but also has a team-high 12 strikeouts so far this season. Trey Sweeney also has 8 hits with a double, a triple and a home run and 5 RBIs.

Why the Detroit Tigers will win

• The White Sox have lost 22 of their last 25 games against AL Central opponents.
• The Tigers have won 14 of their last 17 games against the White Sox.
• The White Sox have failed to cover the run line in eight of their last nine road games against AL Central opponents following a loss.
• The Tigers have covered the run line in seven of their last eight games as favorites against AL Central opponents following a win.

Detroit Tigers Player Prop Facts

• Riley Greene has recorded a Double in three of the Tigers’ last four games against opponents that held a losing record.
• Kerry Carpenter has recorded at least one RBI in each of the Tigers’ last five games as favorites against AL Central opponents.
• Matt Vierling has scored at least one run in each of his last six appearances with the Tigers as home favorites against AL Central opponents.
• Gleyber Torres has recorded at least one hit in each of his last 15 home appearances against opponents that held a losing record.
• Kerry Carpenter has hit at least one home run in four of the Tigers’ last five games as favorites against AL Central opponents.
• Gleyber Torres has recorded at least one Single in each of his last 10 home appearances against AL opponents that held a losing record.
• Riley Greene ranks T2nd in the league in Hits (13) this season.

Total Runs Facts

• Each of the Tigers’ last four games against AL Central opponents have gone OVER the total runs line.
• Five of the White Sox’s last six games against AL Central opponents have gone OVER the total runs line.

Chicago White Sox vs. Detroit Tigers Prediction

I’m on the White Sox +1.5 here. I get the case to be made for the Tigers at home, but I have a hard time trusting the Tigers at the best of times against left-handed pitching, but Perez has been solid for some time now and he also has solid career numbers against the Tigers in some of his recent starts with a sub-three ERA in his last five starts against Detroit. Jackson Jobe is a solid prospect, but I feel like this price with Jobe is rushing it a bit, as he wasn’t stellar in his debut and while the White Sox may be a good lineup to get your feet wet against and to gain some reps against, I think this is the best spot of the entire series for the White Sox to at least keep it close if not end up winning the game outright. Give me Chicago +1.5 here.