Twins vs Astros Prediction 4/6/25 MLB Picks Today

In this article we will formulate a Twins vs Astros prediction for this MLB game on Sunday, April 6th at Target Field in Minneapolis, Minnesota. Let’s take a look at the prediction for this MLB matchup. 

Minnesota Twins Betting Preview

The Minnesota Twins are 3-5 this year after they won game two in this series by a score of 6-1 on Saturday. Minnesota fell behind early in the ball game, but they rallied with the last six runs in the game to cruise to the win. The Twins recorded six hits in the game and they were led by Miranda, who went 1-4 with one home run and three RBIs in the win. Minnesota started Ober, who allowed one earned run and three hits over 4.0 innings, while Varland, Sands, Alcala, Topa, and Duran combined for five shutout innings in relief. 

Prior to this series, the Twins won two out of three against the White Sox and were swept in three games by the Cardinals. The Minnesota pitching staff has a 4.76 ERA with a 1.35 WHIP and a .264 opponent batting average, while their offense has scored 28 runs with a .182 batting average and a .249 on base percentage this year. Harrison Bader has led Minnesota with three home runs and eight RBIs, while Jose Miranda has added one home run and five RBIs this season. The projected starting pitcher for Minnesota is Chris Paddack, who is 0-1 with a 24.30 ERA and a 3.00 WHIP over 3.1 innings pitched this year. 

Houston Astros Betting Preview

The Houston Astros are 3-5 this season after they lost game two on Saturday afternoon, but they did win game one of this series by a score of 5-2. In the game two loss, the Astros took a 1-0 lead in the first inning, but they couldn’t find anymore offense in the game for the loss. The Astros recorded nine hits and committed two errors in the game, while they were led by Altuve, who went 3-5 with one home run and one RBI in the loss. Houston started Arrighetti in the game, who allowed three hits and five earned runs over 3.2 innings, while Scott, Gusto, and Okert allowed zero earned runs over the final 4.1 innings. 

Prior to this series, the Astros were swept in three games by the Giants and won two out of three against the Mets. The Houston pitching staff has a 3.42 ERA with a 1.03 WHIP and a .168 opponent batting average, while the offense has scored 18 runs with a .199 batting average and a .279 on base percentage this season. Yordan Alvarez has led Houston with four RBIs, while Altuve has added two home runs and two RBIs this year. The projected starting pitcher for Houston is Ronel Blanco, who is 0-1 with a 5.40 ERA and a 1.20 WHIP over 5.0 innings pitched this season. 

Why the Astros will beat the Twins

• The Twins have lost each of their last five games as home favorites after playing the previous day.
• The Astros have won five of their last six games as underdogs against AL Central opponents following a loss.
• The Astros have covered the run line in each of their last nine games as underdogs against American League opponents following a loss.
• The Twins have failed to cover the run line in each of their last six day games against the Astros following a win.
• The Twins have lost the first inning in three of their last four home games against opponents that held a losing record.
• The Astros have led after 3 innings in four of their last five road games against American League opponents.
• The Astros have led after 5 innings in seven of their last eight road games against American League opponents that held a losing record.

Total Runs Facts

• Eight of the Astros’ last nine games as road underdogs have gone UNDER the total runs line.
• Eight of the Twins’ last 10 home games after playing the previous day have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Astros’ last 10 Sunday games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Twins’ last seven day games.

Minnesota Twins Player Prop Facts

• Harrison Bader has hit a home run in two of his last three appearances with the Twins against AL opponents.
• Jose Miranda has recorded at least one RBI in four of his last five appearances against the Astros after playing the previous day.
• Ty France has recorded at least one Single in seven of his last eight appearances against AL West opponents.
• Byron Buxton has scored at least one run in each of his last six home appearances against AL West opponents.
• Trevor Larnach has recorded at least one hit in each of his last seven home appearances against AL West opponents that held a losing record.
• Christian Vazquez has recorded a Double in three of his last four home appearances against AL West opponents.

Houston Astros Player Prop Facts

• Brendan Rodgers has recorded a Double in four of his last five appearances with his team as an underdog.
• Christian Walker has hit a home run in each of his last two road appearances against the Twins after playing the previous day.
• Jose Altuve has scored at least one run in each of his last eight Sunday appearances against AL Central teams that held a losing record.
• Yordan Alvarez has recorded at least one RBI in each of his last six Sunday appearances against AL Central teams that held a losing record.
• Jose Altuve has recorded at least one Single in each of his last eight Sunday appearances against AL Central teams that held a losing record.
• Jeremy Pena has recorded at least one hit in each of the Astros’ last nine games against AL opponents that held a losing record.

Twins vs Astros Prediction 

Both of these teams come into this contest with a 3-5 record on the season and they will fight for the series win here. Houston has had a pretty solid pitching staff to open the year, but they are last in the MLB in runs scored. Minnesota is slightly better in runs scored, but their pitching staff has an ERA of 4.76 on the year. The Twins will start Paddack, who allowed nine earned runs against the White Sox in his first start, while Houston will go with Blanco, who allowed three earned runs to the Giants. I am going to fade Paddack after that disastrous first start and take Houston to win here.