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Twins vs Astros Prediction 5/19/26 MLB Picks Today

Houston Astros (19-30) vs. Minnesota Twins (22-26)
May 19, 2026 7:40 pm EDT
The Line: Minnesota Twins -137 / Houston Astros 114; Over/Under: 8.5
(Get latest betting odds)

In this article we will formulate a Twins vs Astros prediction for this MLB game on Tuesday, May 19th at Target Field in Minneapolis, Minnesota. Let’s take a look at the prediction for this MLB matchup. 

Minnesota Twins Betting Preview

The Minnesota Twins are 22-26 this year after they won game one by a score of 6-3 on Monday night. Minnesota led 6-0 in the sixth inning and they were able to get the win, but the game did get pretty close. The Twins recorded nine hits in the game and they were led by Bell, who went 3-4 with two home runs and four RBIs. Rojas allowed two hits and zero earned runs over 4.0 innings, while Orze got the win and Rogers picked up the save. Prior to this series, Minnesota lost two out of three against the Brewers, but did win two out of three against the Marlins before that. 

This season, Minnesota has a 4.32 ERA with a 1.35 WHIP and a .246 opponent batting average, while they have scored 225 runs with a .236 batting average and a .324 on base percentage. Byron Buxton has led the Twins with 15 home runs and 23 RBIs, while Ryan Jeffers has added seven home runs and 26 RBIs. The projected starting pitcher for Minnesota is Zebby Matthews, who is 1-0 with a 0.00 ERA and a 0.71 WHIP over 7.0 innings pitched this year. 

Houston Astros Betting Preview

The Houston Astros are 19-30 this season after they lost game one by a score of 6-3 last night. Houston scored three runs in the seventh inning, but they stranded over 10 baserunners in the loss. The Astros recorded seven hits in the game and they were led by Walker, who went 2-5 with one RBI. Imai allowed five hits and three earned runs over 4.2 innings for the loss, while Murray allowed three earned runs in relief. Prior to this series, Houston won two out of three against the Rangers, but lost three out of four against the Mariners before that. 

This season, Houston has a 5.45 ERA with a 1.55 WHIP and a .257 opponent batting average, while they have scored 215 runs with a .250 batting average and a .327 on base percentage. Yordan Alvarez has led the Astros with 15 home runs and 31 RBIs, while Christian Walker has added 11 home runs and 31 RBIs. The projected starting pitcher for Houston is Lance McCullers Jr, who is 2-3 with a 6.86 ERA and a 1.53 WHIP over 39.1 innings pitched this season. 

Why the Minnesota Twins will win

  • The Astros have lost seven of their last eight night games against AL Central opponents.
  • The home team has won each of the last four games between the Astros and Twins.
  • The Astros have failed to cover the run line in nine of their last 10 night games against AL Central opponents that held a losing record.
  • The Twins have covered the run line in four of their last five games.
  • The Twins have led after 3 innings in five of their last six games as favorites.
  • The Twins have led after 5 innings in nine of their last 10 night games at Target Field against American League opponents.

Why the Houston Astros will win

  • The Twins have lost 13 of their last 15 games as favorites after playing the previous day.
  • The Astros have won each of their last eight Tuesday games against the Twins.
  • The Astros have covered the run line in each of their last seven games as underdogs against AL Central opponents following a road loss.
  • The Twins have failed to cover the run line in 13 of their last 15 games as favorites after playing the previous day.
  • The Twins have trailed after 3 innings in 12 of their last 16 games as favorites against American League opponents.
  • The Astros have led after 5 innings in each of their last six Tuesday night games against the Twins.

Total Runs Facts

  • Six of the Astros’ last eight night games against American League opponents have gone UNDER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Twins’ last 11 home games against AL West opponents.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of Lance McCullers Jr.’s last six appearances as a starter.

Minnesota Twins Player Prop Facts

  • Trevor Larnach has recorded at least one hit in 18 of his last 19 home appearances against AL West opponents that held a losing record.
  • Byron Buxton has hit at least one home run in each of his last six appearances in night games against AL teams that held a losing record.

Houston Astros Player Prop Facts

  • Christian Walker has hit at least one home run in 12 of his last 29 road appearances against opponents that held a losing record.
  • Lance McCullers Jr. has recorded five or more strikeouts in 10 of his last 12 appearances in night games against AL teams that held a losing record.
  • Jose Altuve has recorded a hit in each of his last seven road appearances.
  • Yordan Alvarez ranks 1st amongst qualified players for On Base Percentage (.427) this season.

Matchup/League Facts

  • The Twins rank 26th in the league for strikeouts this season (360).
  • The Twins rank 24th in the league for runs allowed this season (228).
  • The Astros rank 30th in the league for ERA this season (5.45).
  • The Astros rank 30th in the league for walks allowed this season (245).

Twins vs Astros Prediction 

Minnesota was able to get the win on Monday to start this series and they have won three of their last five games. The Twins are 14-13 at home this year, while the Astros are 7-16 on the road. Houston has lost two in a row and they have allowed 6+ runs in three of their last five games. The Astros are starting McCullers Jr, who has allowed 2, 6, 3, 5, and 4 earned runs in his last five starts, while Matthews allowed four hits and zero earned runs in his first start against Miami. Take the Twins to win at home here. 

David Racey's Free Pick: Twins ML

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David Racey

David started writing about sports in 2015, but sports has been his passion for as long as he can remember. David spends most of his free time watching pretty much anything sports related from Baseball to Tennis and everything in between. David likes to analyze statistics and recent results to form an unbiased opinion on whatever game he is breaking down. Follow David on Twitter at @itsyerboi41

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