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Cavaliers vs Pacers Prediction 4/5/26 NBA Picks Today

Indiana Pacers (18-59) vs. Cleveland Cavaliers (48-29)
April 5, 2026 6:00 pm EDT
The Line: Cleveland Cavaliers -16.5; Over/Under: 240.5
(Get latest betting odds)

The Indiana Pacers and Cleveland Cavaliers meet Sunday in NBA action at the Rocket Arena. Here’s a Cavaliers vs. Pacers Prediction. This article will include a Cavaliers vs. Pacers Pick.

Indiana Pacers Betting Preview

The Indiana Pacers beat the Bulls and lost to the Hornets, and they play the Timberwolves next. The Pacers have lost 23 of their last 28 games.

The Indiana Pacers are averaging 111.9 points on 45.6 percent shooting and allowing 120.7 points on 49.1 percent shooting. Pascal Siakam is averaging 23.7 points and 6.6 rebounds, while Andrew Nembhard is averaging 17 points and 2.8 rebounds. Obi Toppin is the third double-digit scorer, and Aaron Nesmith is grabbing 4.4 rebounds. The Indiana Pacers are shooting 35.3 percent from beyond the arc and 77.3 percent from the free-throw line. The Indiana Pacers are allowing 35.6 percent shooting from deep and are grabbing 41.7 rebounds per game.

Cleveland Cavaliers Betting Preview

The Cleveland Cavaliers beat the Warriors and lost to the Lakers, and they play the Grizzlies next. The Cavs have won 11 of their last 16 games.

The Cleveland Cavaliers are averaging 119.4 points on 47.9 percent shooting and allowing 115.2 points on 46.3 percent shooting. Donovan Mitchell is averaging 28.2 points and 5.9 assists, while Max Strus is averaging 24 points and 1 assist. James Harden is the third double-digit scorer, and Evan Mobley is grabbing 8.7 rebounds. The Cleveland Cavaliers are shooting 36.1 percent from beyond the arc and 77.6 percent from the free-throw line. The Cleveland Cavaliers are allowing 36.8 percent shooting from deep and are grabbing 44.3 rebounds per game.

Why the Cleveland Cavaliers will win

  • The Cavaliers have won each of their last nine games against Pacers teams that held a losing record.
  • The Pacers have lost each of their last seven games against Central Division opponents that held a winning record.
  • The home team has covered the spread in each of the Cavaliers’ last four games.
  • The Pacers have failed to cover the spread in six of their last seven road games when playing with a rest disadvantage.

Why the Indiana Pacers will win

  • The Pacers have won four of their last five games as road underdogs against the Cavaliers.
  • The Cavaliers have lost each of their last five Sunday games as home favorites.
  • The Cavaliers have failed to cover the spread in each of their last 11 games as favorites following a win.
  • The Pacers have covered the spread in each of their last six road games against the Cavaliers.

Total Points: Facts

  • Twelve of the Pacers’ last 13 games as road underdogs have gone OVER the total points line.
  • Each of the Cavaliers’ last five games against the Pacers, following a road win, have gone OVER the total points line.

Cleveland Cavaliers Player Facts

  • James Harden has recorded 63 games with 5+ assists this season—equal to the most of any player in the league.
  • Donovan Mitchell is one of only four players in the league to have made 7+ threes in consecutive games this season.

Indiana Pacers Player Facts

  • Jay Huff ranks 1st in the Eastern Conference amongst qualified players for blocks per game (1.8) this season.

Matchup/League Facts

  • The Cavaliers rank 1st in the league for Q4 points per game this season (30.0).
  • The Cavaliers rank 1st in the league for H2 points per game this season (61.0).
  • The Pacers have suffered the largest comeback loss when leading through Q1 this season—led by 21 points vs. the Clippers on March 27.
  • The Pacers rank 30th in the league for Q3 win percentage this season (35.1%).

Cavaliers vs Pacers Injury Report

The Cavs will be without Dean Wade, Evan Mobley, Jarrett Allen, Sam Merrill, and Jaylon Tyson.

The Pacers will be without Tyrese Haliburton, Johnny Furphy, Jarace Walker, Aaron Nesmith, TJ McConnell, Andrew Nembhard, and Ivica Zubac.

Cavaliers vs Pacers Prediction

The Cavs have the ability to blow the doors off, but they have a lengthy injury report and are 30-46-1 ATS on the season. If you’ve been blindly fading the Cavs this season, you’re doing well. With a cover percentage under 40 percent, the Cavs are the worst cover team in the NBA. Also, the Pacers aren’t winning but they’ve covered 7 of their last 8 games. The only option in this spot is grabbing the boatload of points with the Pacers.

Randy Chambers's Free Pick: Indiana Pacers +16.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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