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Knicks vs 76ers Prediction 10/20/26 NBA Picks Today

Philadelphia 76ers (1-3) vs. NY Knicks (1-4)
October 20, 2026 7:00 pm EDT
The Line: NY Knicks -4.5; Over/Under: 232.5
(Get latest betting odds)

The Philadelphia 76ers and New York Knicks meet Tuesday in NBA action at Madison Square Garden. Here’s a Knicks vs. 76ers Prediction. This article will include a Knicks vs. 76ers pick.

Philadelphia 76ers Betting Preview

The 76ers have made the playoffs in 8 of their last 9 seasons and enter year four under coach Nick Nurse.

The 76ers went from cute playoff team to legit title contender with the additions of Jaylen Brown and LeBron James. Add them to Tyrese Maxey, VJ Edgecombe, and Joel Embiid, and Philly has possibly the most talented starting five in the NBA. Kentavious Caldwell-Pope and Anfernee Simons coming off the bench as well is nothing to sneeze at. The 76ers have emerged quickly as a popular title bet in the futures market. The biggest question is fit, as there’s only one ball for guys used to high usage. Also, Embiid has issues staying healthy, and LeBron is 42 years old in December. Still, the talent is there for the 76ers to win their first title since the 80s.   

New York Knicks Betting Preview

The Knicks just won their first title since the 70s and enter year two under coach Mike Brown. We’ll see what’s in store for the Knicks in their encore season.

The Knicks bring back their entire core, outside of losing Mitchell Robinson to the Celtics. They replaced him with Andre Drummond. The Knicks are built on chemistry and friendship, and after just winning a title, it’s hard to bet against. The Knicks are the East favorites until proven otherwise, and there’s no reason to get cute with any splashy moves. However, like all teams that just won a chip, motivation could be an issue in the regular season after a long championship run. There’s also now a target on their back, and the East has gotten tougher. Regardless, basketball is alive and well in NYC.

Why the New York Knicks will win

  • The Knicks have won each of their last 13 games against Atlantic Division opponents.
  • The 76ers have lost each of their last four games.
  • The Knicks have covered the spread in each of their last six games against Eastern Conference opponents.
  • The 76ers have failed to cover the spread in three of their last four games.

Why the Philadelphia 76ers will win

  • The underdogs have won four of the Knicks’ last five games.
  • The Knicks have lost seven of their last nine home openers against Atlantic Division opponents.
  • The road team has covered the spread in each of the Knicks’ last seven games.
  • The Knicks have failed to cover the spread in four of their last five home openers against Atlantic Division opponents.

Total Points Facts

  • Eight of the 76ers’ last nine road openers as underdogs have gone OVER the total points line.
  • Five of the Knicks’ last six season openers against Eastern Conference opponents have gone OVER the total points line.

New York Knicks Player Facts

  • Jalen Brunson has scored 25+ points in three consecutive appearances – equal-longest active streak of any player in the league.
  • Karl-Anthony Towns ranked 2nd amongst qualified players for rebounds per game (11.9) last season.

Philadelphia 76ers Player Facts

  • Tyrese Maxey ranked 1st in the league for fast break points (382) last season.
  • LeBron James ranked 1st amongst qualified players for fast break points per game (5.7) last season.

Matchup/League Facts

  • The Knicks ranked 1st in the league for opponent offensive rebounds per game last season (10.0).
  • The Knicks recorded the most wins when trailing after Q1 last season (22).
  • The 76ers recorded the most wins when trailing by a margin of 10+ points through Q3 last season (4).
  • The 76ers suffered the equal-most losses by a margin of 40+ points last season (3).

Knicks vs 76ers Prediction

You can argue the value is with the 76ers and the points, as they’re one of the more talented teams in the league, and if things break right, they won’t be the underdog often. It’s also Banner Night, which has a history of throwing the champs off. However, the 76ers are a new roster, and it’s going to take time to figure things out. The Knicks have chemistry, and that’s often key early in the season. Also, there’s a lot of hype around the 76ers, and some are already crowning them. That should give the Knicks early motivation to make a statement. I’ll lay the points with the Knicks.

Randy Chambers's Free Pick: NY Knicks -4.5

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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