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Lakers vs Trail Blazers Prediction 10/27/25 NBA Picks Today
Portland Trailblazers (1-2) vs. LA Lakers (2-1)
October 27, 2025 10:30 pm EDT
The Line: LA Lakers +1; Over/Under:
(Get latest betting odds)
The Portland Trail Blazers and the Los Angeles Lakers collide at the Crypto.com Arena on Monday night. Here’s a Lakers vs Trail Blazers Prediction. This article will include a Lakers vs Trail Blazers Pick.
Portland Trail Blazers Betting Preview
The Portland Trail Blazers have had a rough start to the season as they’ve dropped two of their first three games. They will be hoping to bounce back in this one after falling just short to the Clippers in a 114-107 road defeat last night. Deni Avdija led the team with 23 points, seven rebounds and five assists, Jrue Holiday added 21 points with six rebounds and seven assists while Shaedon Sharpe chipped in with 19 points and five rebounds.
As a team, the Trail Blazers shot just 37 percent from the field and 11 of 41 from the 3-point line as they exploded for 37 points in the second quarter to turn an early 11-point deficit into a 12-point lead. However, they couldn’t maintain that pace in the second half and couldn’t get over the hump once the Clippers used a pivotal 11-4 run in the fourth quarter to pull away again. The Trail Blazers forced the Clippers into 22 turnovers, but they just needed more help from their bench as Jerami Grant was the only reserve player to score more than six points as he finished with 17 points.
Los Angeles Lakers Betting Preview
Meanwhile, the Los Angeles Lakers dropped their season opener, but they are now aiming for a third straight victory after last night’s 127-120 road win over the Kings. Austin Reaves led the team with a career-high 51 points, 11 rebounds and nine assists on 12 of 22 shooting, Deandre Ayton added 22 points with 15 rebounds while Rui Hachimura chipped in with an efficient 18 points on seven of 10 shooting.
As a team, the Lakers shot 48 percent from the field and eight of 25 from the 3-point line as they set the tone with 36 points in the first quarter to take an early 11-point lead. Before they went on a 15-6 run late in the third quarter to start to pull away and earn the gritty win without two of their best players in LeBron James and Luka Doncic who were both sitting out injured.
Why the Los Angeles Lakers will win
- The Trail Blazers have lost each of their last 14 night games at Crypto.com Arena.
- The Lakers have won each of their last nine home games against Northwest Division opponents that held a losing record.
- The Trail Blazers have failed to cover the spread in each of their last six games as road favorites against Western Conference opponents.
- The Lakers have covered the spread in each of their last six games on the second leg of a back-to-back against Western Conference opponents.
Why the Portland Trail Blazers will win
- The favorites have won each of the last eight games between the Trail Blazers and Lakers.
- The Lakers have lost seven of their last eight games on the second leg of a back-to-back against the Trail Blazers.
- The Trail Blazers have covered the spread in each of their last 10 games on the second leg of a back-to-back.
- The Lakers have failed to cover the spread in each of their last six games as home underdogs against Northwest Division opponents following a win.
Total Points Facts
- Each of the Trail Blazers’ last seven games as road favorites against the Lakers have gone UNDER the total points line.
- Each of the Lakers’ last five games as underdogs have gone OVER the total points line.
Matchup/League Facts
- The Lakers rank 1st in the league for field goal percentage this season (54.1%).
- The Lakers rank 30th in the league for field goal attempts per game this season (77.7).
- The Trail Blazers rank 1st in the league for steals per game this season (11.7).
- The Trail Blazers rank 1st in the league for opponent turnovers per game this season (22.7).
Lakers vs Trail Blazers Prediction
The Lakers could be shorthanded again with LeBron James, Luka Doncic, Jaxson Hayes and Maxi Kleber all on the injury report, while the Trail Blazers have again ruled out Scoot Henderson, Damian Lillard and Robert Williams III. Both teams are missing some key players once again, so it comes down to which team has the better depth in the short term.
The Trail Blazers are deserved favorites given that they still have Jrue Holiday, Jerami Grant and Deni Avdija to carry the offense while the Lakers were able to rely on Reaves who delivered last night. You can make an argument for either side, but the Trail Blazers are slight favorites in this spot, and I think they can take advantage of a depleted Lakers team in this spot.



