Spurs vs 76ers Prediction 3/21/25 NBA Picks Today

The Philadelphia 76ers and San Antonio Spurs meet Friday in NBA action at the Frost Bank Center. Here’s a Spurs vs 76ers Prediction. This article will include a Spurs vs 76ers Pick.

Philadelphia 76ers Betting Preview

The Philadelphia 76ers lost to the Rockets and Thunder, and they play the Hawks, Pelicans, and Wizards next. The 76ers have lost 17 of their last 20 games since February 5.

The Philadelphia 76ers are averaging 110 points on 45.6 percent shooting and allowing 115 points on 48.8 percent shooting. Tyrese Maxey is averaging 26.3 points and 6.1 assists, while Kelly Oubre Jr. is averaging 15.1 points and 6.1 rebounds. Guerschon Yabusele is the third double-digit scorer and Jared Butler is grabbing 2.6 rebounds. The Philadelphia 76ers are shooting 34.7 percent from beyond the arc and 78.6 percent from the free-throw line. The Philadelphia 76ers are allowing 37 percent shooting from deep and are grabbing 39.4 rebounds per game.

San Antonio Spurs Betting Preview

The San Antonio Spurs lost to the Lakers, beat the Knicks, and then play the Raptors, Pistons, and Cavs next. The Spurs look for two straight wins for the first time since December 31 – January 3.

The San Antonio Spurs are averaging 114.2 points on 46.6 percent shooting and allowing 116.6 points on 47.4 percent shooting. Devin Vassell is averaging 16.1 points and 3.9 rebounds, while Stephon Castle is averaging 13.8 points and 3.5 assists. Keldon Johnson is the third double-digit scorer and Harrison Barnes is dishing 1.7 assists. The San Antonio Spurs are shooting 35.3 percent from beyond the arc and 77.4 percent from the free-throw line. The San Antonio Spurs are allowing 36.3 percent shooting from deep and are grabbing 43.9 rebounds per game.

Why the San Antonio Spurs will win

• The 76ers have lost each of their last 10 games at Frost Bank Center following a road loss.
• The Spurs have won 28 of their last 30 games as home favorites against Atlantic Division opponents.
• The 76ers have failed to cover the spread in each of their last nine games as road underdogs following a road loss.
• The Spurs have covered the spread in each of their last five games against Atlantic Division opponents that held a losing record.

Why the Philadelphia 76ers will win

• The Spurs have lost each of their last 11 games following a win.
• The underdogs have won four of the Spurs’ last five games at Frost Bank Center.
• The Spurs have failed to cover the spread in each of their last seven games following a win.
• The road team has covered the spread in each of the last six games between the 76ers and Spurs.

Spurs vs 76ers Injury Report

The San Antonio Spurs will be without Riley Minix, De’Aaron Fox, Victor Wembanyama, and Charles Bassey.

The 76ers will be without Jared McCain, Eric Gordon, Joel Embiid, Paul George, Tyrese Maxey, Andre Drummond, Lonnie Walker IV, Kyle Lowry, Kelly Oubre Jr., and Adem Bona. Guerschon Yabusele is questionable.

Spurs vs 76ers Prediction

I’m not excited to lay this many points with the Spurs, a team that’s been free-falling these last couple of months and hasn’t won back-to-back games in three months. However, the Spurs still have some NBA talent on the court, which gives them the edge here. We can’t say the same for the 76ers, who have nearly their entire roster on the injury report.

The 76ers are also 26-43 ATS on the season, which is the worst cover percentage in the NBA at 37.6 percent. As I’ve said before, the 76ers are fade material, and you’re sitting on a mountain of profit if you just blindly bet against them all season. That doesn’t change just because the opponent is the Spurs. I’ll lay the points.